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• W4295753319 endingPage "8168" @default.
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• W4295753319 abstract "Chronic visceral pain is a major challenge for both patients and health providers. Although the central sensitization of the brain is thought to play an important role in the development of visceral pain, the detailed neural circuits remain largely unknown. Using a well-established chronic visceral hypersensitivity model induced by neonatal maternal deprivation (NMD) in male mice, we identified a distinct pathway whereby the claustrum (CL) glutamatergic neuron projecting to the anterior cingulate cortex (ACC) is critical for visceral pain but not for CFA-evoked inflammatory pain. By a combination of in vivo circuit-dissecting extracellular electrophysiological approaches and visceral pain related electromyographic (EMG) recordings, we demonstrated that optogenetic inhibition of CL glutamatergic activity suppressed the ACC neural activity and visceral hypersensitivity of NMD mice whereas selective activation of CL glutamatergic activity enhanced the ACC neural activity and evoked visceral pain of control mice. Further, optogenetic studies demonstrate a causal link between such neuronal activity and visceral pain behaviors. Chemogenetic activation or inhibition of ACC neural activities reversed the effects of optogenetic manipulation of CL neural activities on visceral pain responses. Importantly, molecular detection showed that NMD significantly enhances the expression of NMDA receptors and activated CaMKIIα in the ACC postsynaptic density (PSD) region. Together, our data establish a functional role for CL→ACC glutamatergic neurons in gating visceral pain, thus providing a potential treatment strategy for visceral pain.SIGNIFICANCE STATEMENT Studies have shown that sensitization of anterior cingulate cortex (ACC) plays an important role in chronic pain. However, it is as yet unknown whether there is a specific brain region and a distinct neural circuit that helps the ACC to distinguish visceral and somatic pain. The present study demonstrates that claustrum (CL) glutamatergic neurons maybe responding to colorectal distention (CRD) rather than somatic stimulation and that a CL glutamatergic projection to ACC glutamatergic neuron regulates visceral pain in mice. Furthermore, excessive NMDA receptors and overactive CaMKIIα in the ACC postsynaptic density (PSD) region were observed in mice with chronic visceral pain. Together, these findings reveal a novel neural circuity underlying the central sensitization of chronic visceral pain." @default.
• W4295753319 created "2022-09-15" @default.
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• W4295753319 date "2022-09-13" @default.
• W4295753319 modified "2023-10-12" @default.
• W4295753319 title "Identification of a Glutamatergic Claustrum-Anterior Cingulate Cortex Circuit for Visceral Pain Processing" @default.
• W4295753319 cites W1682776306 @default.
• W4295753319 cites W1683418430 @default.
• W4295753319 cites W1863427091 @default.
• W4295753319 cites W1908628105 @default.
• W4295753319 cites W1968998514 @default.
• W4295753319 cites W1989484843 @default.
• W4295753319 cites W1993355744 @default.
• W4295753319 cites W1997428759 @default.
• W4295753319 cites W2010225677 @default.
• W4295753319 cites W2013115334 @default.
• W4295753319 cites W2016773845 @default.
• W4295753319 cites W2031069948 @default.
• W4295753319 cites W2036612423 @default.
• W4295753319 cites W2064638321 @default.
• W4295753319 cites W2065371327 @default.
• W4295753319 cites W2066106589 @default.
• W4295753319 cites W2066407767 @default.
• W4295753319 cites W2070809195 @default.
• W4295753319 cites W2072029636 @default.
• W4295753319 cites W2072496475 @default.
• W4295753319 cites W2074726570 @default.
• W4295753319 cites W2094795912 @default.
• W4295753319 cites W2105030178 @default.
• W4295753319 cites W2109999014 @default.
• W4295753319 cites W2113066364 @default.
• W4295753319 cites W2116893918 @default.
• W4295753319 cites W2139406295 @default.
• W4295753319 cites W2141539606 @default.
• W4295753319 cites W2154569857 @default.
• W4295753319 cites W2285903269 @default.
• W4295753319 cites W2338161804 @default.
• W4295753319 cites W2405482068 @default.
• W4295753319 cites W2426802935 @default.
• W4295753319 cites W2470750263 @default.
• W4295753319 cites W2517333721 @default.
• W4295753319 cites W2562904427 @default.
• W4295753319 cites W2590190415 @default.
• W4295753319 cites W2604157053 @default.
• W4295753319 cites W2791753861 @default.
• W4295753319 cites W2800913246 @default.
• W4295753319 cites W2886239953 @default.
• W4295753319 cites W2891418156 @default.
• W4295753319 cites W2905583441 @default.
• W4295753319 cites W2922725469 @default.
• W4295753319 cites W2942247151 @default.
• W4295753319 cites W2944041689 @default.
• W4295753319 cites W2955122475 @default.
• W4295753319 cites W2969537933 @default.
• W4295753319 cites W2972557997 @default.
• W4295753319 cites W2972864586 @default.
• W4295753319 cites W2987659882 @default.
• W4295753319 cites W2994837026 @default.
• W4295753319 cites W3005310857 @default.
• W4295753319 cites W3023510342 @default.
• W4295753319 cites W3025352447 @default.
• W4295753319 cites W3033434377 @default.
• W4295753319 cites W3036852316 @default.
• W4295753319 cites W3037233432 @default.
• W4295753319 cites W3081140869 @default.
• W4295753319 cites W3104084285 @default.
• W4295753319 cites W3109032036 @default.
• W4295753319 cites W3120509161 @default.
• W4295753319 cites W3127141158 @default.
• W4295753319 cites W3139480415 @default.
• W4295753319 cites W3180269126 @default.
• W4295753319 cites W3180653648 @default.
• W4295753319 cites W3182321648 @default.
• W4295753319 cites W3193807471 @default.
• W4295753319 cites W3210651039 @default.
• W4295753319 cites W4206222539 @default.
• W4295753319 cites W4247022284 @default.
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• W4295753319 doi "https://doi.org/10.1523/jneurosci.0779-22.2022" @default.
• W4295753319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36100399" @default.
• W4295753319 hasPublicationYear "2022" @default.
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