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- W4295771738 abstract "To determine the presence of anti-SARS-CoV-2 antibodies in colostrum and mature milk in women who had SARS-CoV-2 infection during pregnancy or at delivery; to investigate the correlation between anti-SARS-CoV-2 antibodies in milk with antibody in maternal blood, severity of infection and time-interval from active illness; and to evaluate immunoglobulin evolution from colostrum to mature milk. This was a prospective cohort study with consecutive pregnant women with confirmed SARS-CoV-2 infection from six recruiting units in Spain and Hong Kong. Colostrum and mature milk were collected by manual expression with strict contact precautions (facial mask and hand cleaning) and maternal blood sample was also collected. Colostrum samples were tested with rRT-PCR-SARS-CoV-2. Skimmed acellular milk and maternal serum was tested against SARS-CoV-2 specific immunoglobulin M, A and G reactive to the receptor binding domain of the SARS-CoV-2 spike protein 1. All rRT-PCR-SARS-CoV-2 tested negative. IgA and IgG were present in 111/135 (82.2%) and 2/135 (1.5%) colostrum samples and 27/81 (33.3%) and 0/81 mature milk samples, respectively. Concentrations of immunoglobulins were not associated with the timing of infection but women with SARS-CoV-2 pneumonia had higher levels of IgA and IgG in colostrum than those who were asymptomatic or had mild symptoms. No SARS-CoV-2 virus was found in human milk; however, high levels of antibodies were found in colostrum, especially IgA, irrespective of the time of infection. All women should be encouraged to breastfeed, undertaking strict contact precautions when there is active disease." @default.
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- W4295771738 date "2022-09-01" @default.
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- W4295771738 title "OP02.06: Relationship between anti‐SARS‐CoV‐2‐specific antibodies in human breast milk following SARS‐CoV‐2 infection during pregnancy" @default.
- W4295771738 doi "https://doi.org/10.1002/uog.25118" @default.
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