Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295773877> ?p ?o ?g. }
- W4295773877 endingPage "103760" @default.
- W4295773877 startingPage "103760" @default.
- W4295773877 abstract "Transdermal drug delivery is contemplated as one of the top appealing routes for pharmaceutically active ingredients administration owing to the several benefits, specifically over oral and intravenous routes. Unfortunately, factors such as the active agent's molecular weight and hydrophilicity preclude it from being widely used, especially for macromolecular agents of interest such as DNA, peptides, and siRNA coupled with the excellent outermost skin barrier provided by the stratum corneum. Since the last decade, microneedles (MNs) have gained prominence due to their numerous advantages in transdermal drug delivery. MNs are micron-sized needles that can penetrate the subcutaneous skin layer into the epidermal layer without causing pain by evading nerve fibers and capillaries, primarily found in the dermal layer. Because of their efficiency, painlessness, reliability, and feasibility, they are commonly utilized in TDD systems (TDDS). Different varieties of microneedles, such as biodegradable, dissolvable, hollow, and coated can be fabricated using various materials based on the delivery mechanism. In this review, we first elucidated the anatomy of human skin and thereafter highlighted the development and current status of microneedle technology, mechanism of action on the skin, different types of microneedles, and their advances in the delivery of both low molecular weight molecules and biomacromolecules such as proteins and peptides, including their prospective applications in ocular diseases and chemotherapeutic drug delivery. Microneedle technology holds a lot of potential because of the diverse array of materials it can use, as well as the ease with which it can be made for promising therapeutic applications." @default.
- W4295773877 created "2022-09-15" @default.
- W4295773877 creator A5041020224 @default.
- W4295773877 creator A5081190032 @default.
- W4295773877 creator A5084809314 @default.
- W4295773877 date "2022-11-01" @default.
- W4295773877 modified "2023-10-14" @default.
- W4295773877 title "Polymeric microneedles for transdermal drug delivery- a review of recent studies" @default.
- W4295773877 cites W1541116624 @default.
- W4295773877 cites W1573570351 @default.
- W4295773877 cites W1965852633 @default.
- W4295773877 cites W1977812165 @default.
- W4295773877 cites W1981760171 @default.
- W4295773877 cites W1982730207 @default.
- W4295773877 cites W2000657744 @default.
- W4295773877 cites W2001260338 @default.
- W4295773877 cites W2007739515 @default.
- W4295773877 cites W2012594431 @default.
- W4295773877 cites W2019768617 @default.
- W4295773877 cites W2026675007 @default.
- W4295773877 cites W2030468727 @default.
- W4295773877 cites W2039881653 @default.
- W4295773877 cites W2044213662 @default.
- W4295773877 cites W2049074302 @default.
- W4295773877 cites W2055070607 @default.
- W4295773877 cites W2062683657 @default.
- W4295773877 cites W2073386692 @default.
- W4295773877 cites W2075001207 @default.
- W4295773877 cites W2080875706 @default.
- W4295773877 cites W2082795977 @default.
- W4295773877 cites W2083710819 @default.
- W4295773877 cites W2085338797 @default.
- W4295773877 cites W2087943529 @default.
- W4295773877 cites W2089143024 @default.
- W4295773877 cites W2093014785 @default.
- W4295773877 cites W2097570839 @default.
- W4295773877 cites W2128447831 @default.
- W4295773877 cites W2156744813 @default.
- W4295773877 cites W2157286284 @default.
- W4295773877 cites W2158003101 @default.
- W4295773877 cites W2161108328 @default.
- W4295773877 cites W2170823032 @default.
- W4295773877 cites W2218981297 @default.
- W4295773877 cites W2235069160 @default.
- W4295773877 cites W2295627377 @default.
- W4295773877 cites W2299037874 @default.
- W4295773877 cites W2327352318 @default.
- W4295773877 cites W2345853718 @default.
- W4295773877 cites W2410691776 @default.
- W4295773877 cites W2414281682 @default.
- W4295773877 cites W2471277355 @default.
- W4295773877 cites W2510307928 @default.
- W4295773877 cites W2516918670 @default.
- W4295773877 cites W2531808727 @default.
- W4295773877 cites W2564316601 @default.
- W4295773877 cites W2566399670 @default.
- W4295773877 cites W2569734753 @default.
- W4295773877 cites W2588644411 @default.
- W4295773877 cites W2602211937 @default.
- W4295773877 cites W2602994651 @default.
- W4295773877 cites W2604800309 @default.
- W4295773877 cites W2605792741 @default.
- W4295773877 cites W2730912143 @default.
- W4295773877 cites W2765869733 @default.
- W4295773877 cites W2789765839 @default.
- W4295773877 cites W2790192752 @default.
- W4295773877 cites W2796061449 @default.
- W4295773877 cites W2806705214 @default.
- W4295773877 cites W2825488780 @default.
- W4295773877 cites W2884162883 @default.
- W4295773877 cites W2892737456 @default.
- W4295773877 cites W2893808473 @default.
- W4295773877 cites W2894744226 @default.
- W4295773877 cites W2898611803 @default.
- W4295773877 cites W2899970640 @default.
- W4295773877 cites W2900673940 @default.
- W4295773877 cites W2900745351 @default.
- W4295773877 cites W2903909531 @default.
- W4295773877 cites W2905326325 @default.
- W4295773877 cites W2917743440 @default.
- W4295773877 cites W2928472562 @default.
- W4295773877 cites W2942754315 @default.
- W4295773877 cites W2947014661 @default.
- W4295773877 cites W2966827340 @default.
- W4295773877 cites W2967338436 @default.
- W4295773877 cites W2974604900 @default.
- W4295773877 cites W2979404986 @default.
- W4295773877 cites W2981207541 @default.
- W4295773877 cites W2981469174 @default.
- W4295773877 cites W2982261014 @default.
- W4295773877 cites W2995686927 @default.
- W4295773877 cites W2995855903 @default.
- W4295773877 cites W2996449600 @default.
- W4295773877 cites W2996732053 @default.
- W4295773877 cites W2996828628 @default.
- W4295773877 cites W2998124840 @default.
- W4295773877 cites W2998238363 @default.
- W4295773877 cites W3004987277 @default.