FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295777025> ?p ?o ?g. }

• W4295777025 endingPage "103802" @default.
• W4295777025 startingPage "103802" @default.
• W4295777025 abstract "According to the World Health Organization (WHO), an estimated 37.7 million people were living with HIV in 2020. Dolutegravir is recommended as the first line and second line antiretroviral drug for the treatment of HIV-1 infection in combination with NRTI and NNRTI in all populations. It is the second-generation integrase strand transfer inhibitor which is preferred over elvitegravir and raltegravir because of enhanced elimination half-life, reduced dosing frequency, and higher barrier to resistance. Dolutegravir is available in the market in the form of oral tablet for the treatment of HIV-1 infection in all populations. Several other formulations including long-acting gastroretentive dosage form, long-acting injectables, in-situ forming implants, nasal, and vaginal formulations have also been reported which have shown promising results in the treatment of HIV-1 infection in preclinical studies. In the future, clinical translation of the long-acting formulations will enhance the adherence to the therapy by the patient and bring us closer to the goal of eradicating HIV as an epidemic by 2030. The present review elaborates on different strategies which have been reported for the delivery of dolutegravir in adults and paediatrics. • Dolutegravir is the first-line treatment in combination with NRTI or NNRTI of HIV-1 infection in all population. • Dolutegravir oral tablets has been approved by regulatory agency for the treatment of HIV-1 infection. • Long-acting injectables and in-situ forming implants have recently been developed for long-acting release of dolutegravir." @default.
• W4295777025 created "2022-09-15" @default.
• W4295777025 creator A5031541523 @default.
• W4295777025 creator A5045427081 @default.
• W4295777025 date "2022-10-01" @default.
• W4295777025 modified "2023-09-26" @default.
• W4295777025 title "Current status of dolutegravir delivery systems for the treatment of HIV-1 infection" @default.
• W4295777025 cites W1060483835 @default.
• W4295777025 cites W1722558419 @default.
• W4295777025 cites W1966808583 @default.
• W4295777025 cites W1967035954 @default.
• W4295777025 cites W1971027802 @default.
• W4295777025 cites W1985130601 @default.
• W4295777025 cites W1994620171 @default.
• W4295777025 cites W2006691069 @default.
• W4295777025 cites W2007793290 @default.
• W4295777025 cites W2013322539 @default.
• W4295777025 cites W2021500752 @default.
• W4295777025 cites W2032367420 @default.
• W4295777025 cites W2057334151 @default.
• W4295777025 cites W2061002981 @default.
• W4295777025 cites W2064678175 @default.
• W4295777025 cites W2068531357 @default.
• W4295777025 cites W2070702301 @default.
• W4295777025 cites W2075002394 @default.
• W4295777025 cites W2075144974 @default.
• W4295777025 cites W2085120686 @default.
• W4295777025 cites W2092178328 @default.
• W4295777025 cites W2094303174 @default.
• W4295777025 cites W2098605123 @default.
• W4295777025 cites W2119676700 @default.
• W4295777025 cites W2134212900 @default.
• W4295777025 cites W2145513855 @default.
• W4295777025 cites W2151589354 @default.
• W4295777025 cites W2167246391 @default.
• W4295777025 cites W2168692660 @default.
• W4295777025 cites W2222524673 @default.
• W4295777025 cites W2323497364 @default.
• W4295777025 cites W2469037914 @default.
• W4295777025 cites W2586233814 @default.
• W4295777025 cites W2728117782 @default.
• W4295777025 cites W2769261452 @default.
• W4295777025 cites W2781350987 @default.
• W4295777025 cites W2790446992 @default.
• W4295777025 cites W2802170264 @default.
• W4295777025 cites W2803300108 @default.
• W4295777025 cites W2807026831 @default.
• W4295777025 cites W2900399017 @default.
• W4295777025 cites W2936355118 @default.
• W4295777025 cites W2952512346 @default.
• W4295777025 cites W2974040532 @default.
• W4295777025 cites W2981363003 @default.
• W4295777025 cites W2994634169 @default.
• W4295777025 cites W2997604373 @default.
• W4295777025 cites W3011190747 @default.
• W4295777025 cites W3012539753 @default.
• W4295777025 cites W3027089325 @default.
• W4295777025 cites W3036716176 @default.
• W4295777025 cites W3041713186 @default.
• W4295777025 cites W3047456007 @default.
• W4295777025 cites W3087684284 @default.
• W4295777025 cites W3103741069 @default.
• W4295777025 cites W3108044356 @default.
• W4295777025 cites W3109345948 @default.
• W4295777025 cites W3112397674 @default.
• W4295777025 cites W3113283793 @default.
• W4295777025 cites W3128150395 @default.
• W4295777025 cites W3134283065 @default.
• W4295777025 cites W3143772066 @default.
• W4295777025 cites W3145460659 @default.
• W4295777025 cites W3166301720 @default.
• W4295777025 cites W3173517540 @default.
• W4295777025 cites W3176688087 @default.
• W4295777025 cites W3177982925 @default.
• W4295777025 cites W3192649598 @default.
• W4295777025 cites W4281706677 @default.
• W4295777025 doi "https://doi.org/10.1016/j.jddst.2022.103802" @default.
• W4295777025 hasPublicationYear "2022" @default.
• W4295777025 type Work @default.
• W4295777025 citedByCount "0" @default.
• W4295777025 crossrefType "journal-article" @default.
• W4295777025 hasAuthorship W4295777025A5031541523 @default.
• W4295777025 hasAuthorship W4295777025A5045427081 @default.
• W4295777025 hasConcept C142462285 @default.
• W4295777025 hasConcept C159047783 @default.
• W4295777025 hasConcept C2779502633 @default.
• W4295777025 hasConcept C2993143319 @default.
• W4295777025 hasConcept C3013748606 @default.
• W4295777025 hasConcept C71924100 @default.
• W4295777025 hasConceptScore W4295777025C142462285 @default.
• W4295777025 hasConceptScore W4295777025C159047783 @default.
• W4295777025 hasConceptScore W4295777025C2779502633 @default.
• W4295777025 hasConceptScore W4295777025C2993143319 @default.
• W4295777025 hasConceptScore W4295777025C3013748606 @default.
• W4295777025 hasConceptScore W4295777025C71924100 @default.
• W4295777025 hasLocation W42957770251 @default.
• W4295777025 hasOpenAccess W4295777025 @default.
• W4295777025 hasPrimaryLocation W42957770251 @default.

• next