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- W4295808045 abstract "Background Long-term alcohol exposure is associated with oxidative stress, endoplasmic reticulum (ER) stress, and neuroinflammation, which may impair cognitive function. Probiotics supplements can significantly improve cognitive function in neurodegenerative diseases such as Alzheimer’s disease. Nevertheless, the effect of Lactobacillus plantarum ST-III culture supernatant (LP-cs) on alcohol-induced cognitive dysfunction remains unclear. Methods A mouse model of cognitive dysfunction was established by intraperitoneal injection of alcohol (2 g/kg body weight) for 28 days. Mice were pre-treated with LP-cs, and cognitive function was evaluated using the Morris water maze test. Hippocampal tissues were collected for biochemical and molecular analysis. Results LP-cs significantly ameliorated alcohol-induced decline in learning and memory function and hippocampal morphology changes, neuronal apoptosis, and synaptic dysfunction. A mechanistic study showed that alcohol activated protein kinase R-like endoplasmic reticulum kinase (PERK) signaling and suppressed brain derived neurotrophic factor (BDNF) levels via ER stress in the hippocampus, which LP-cs reversed. Alcohol activated oxidative stress and inflammation responses in the hippocampus, which LP-cs reversed. Conclusion LP-cs significantly ameliorated alcohol-induced cognitive dysfunction and cellular stress. LP-cs might serve as an effective treatment for alcohol-induced cognitive dysfunction." @default.
- W4295808045 created "2022-09-15" @default.
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- W4295808045 date "2022-09-14" @default.
- W4295808045 modified "2023-09-25" @default.
- W4295808045 title "Lactobacillus plantarum ST-III culture supernatant ameliorates alcohol-induced cognitive dysfunction by reducing endoplasmic reticulum stress and oxidative stress" @default.
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- W4295808045 cites W1980354712 @default.
- W4295808045 cites W1984436557 @default.
- W4295808045 cites W1984460802 @default.
- W4295808045 cites W1988149172 @default.
- W4295808045 cites W2008564475 @default.
- W4295808045 cites W2014530155 @default.
- W4295808045 cites W2015607285 @default.
- W4295808045 cites W2019548778 @default.
- W4295808045 cites W2030168433 @default.
- W4295808045 cites W2039252406 @default.
- W4295808045 cites W2041285433 @default.
- W4295808045 cites W205881385 @default.
- W4295808045 cites W2064536606 @default.
- W4295808045 cites W2071004543 @default.
- W4295808045 cites W2078740239 @default.
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- W4295808045 cites W2127732414 @default.
- W4295808045 cites W2130304075 @default.
- W4295808045 cites W2135919238 @default.
- W4295808045 cites W2137522359 @default.
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- W4295808045 cites W2509317752 @default.
- W4295808045 cites W2548352647 @default.
- W4295808045 cites W2605240953 @default.
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- W4295808045 cites W2614346335 @default.
- W4295808045 cites W2772926575 @default.
- W4295808045 cites W2796135954 @default.
- W4295808045 cites W2801932266 @default.
- W4295808045 cites W2890164529 @default.
- W4295808045 cites W2891467680 @default.
- W4295808045 cites W2899898342 @default.
- W4295808045 cites W2904256584 @default.
- W4295808045 cites W2937188981 @default.
- W4295808045 cites W2966102363 @default.
- W4295808045 cites W2969790734 @default.
- W4295808045 cites W2980404469 @default.
- W4295808045 cites W2981003714 @default.
- W4295808045 cites W2996536203 @default.
- W4295808045 cites W3011887437 @default.
- W4295808045 cites W3028672565 @default.
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- W4295808045 cites W3095883067 @default.
- W4295808045 cites W3109492384 @default.
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- W4295808045 cites W3129512597 @default.
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- W4295808045 cites W3155332224 @default.
- W4295808045 cites W3158430531 @default.
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- W4295808045 cites W3175309626 @default.
- W4295808045 cites W3194713480 @default.
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- W4295808045 doi "https://doi.org/10.3389/fnins.2022.976358" @default.
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