FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295809076> ?p ?o ?g. }

• W4295809076 abstract "Background Breast cancer is one of the most important diseases in women around the world. Glycosylation modification correlates with carcinogenesis and roles of glycogenes in the clinical outcome and immune microenvironment of breast cancer are unclear. Methods A total of 1297 breast cancer and normal cases in the TCGA and GTEx databases were enrolled and the transcriptional and survival information were extracted to identify prognostic glycogenes using Univariate Cox, LASSO regression, Multivariate Cox analyses and Kaplan-Meier method. The immune infiltration pattern was explored by the single sample gene set enrichment method. The HLA and immune checkpoint genes expression were also compared in different risk groups. The expressions of a glycogene MGAT5 as well as its products were validated by immunohistochemistry and western blotting in breast cancer tissues and cells. Results A 19-glycogene signature was identified to separate breast cancer patients into high- and low-risk groups with distinct overall survival rates ( P &lt; 0.001). Compared with the high-risk group, proportion of naive B cells, plasma cells and CD8 + T cells increased in the low-risk group ( P &lt; 0.001). Besides, expressions of HLA and checkpoint genes, such as CD274, CTLA4, LAG3 and TIGIT3, were upregulated in low-risk group. Additionally, highly expressed MGAT5 was validated in breast cancer tissues and cells. Downstream glycosylation products of MGAT5 were all increased in breast cancer. Conclusions We identified a 19-glycogene signature for risk prediction of breast cancer patients. Patients in the low-risk group demonstrated a higher immune infiltration and better immunotherapy response. The validation of MGAT5 protein suggests a probable pathway and target for the development and treatment of breast cancer." @default.
• W4295809076 created "2022-09-15" @default.
• W4295809076 creator A5002050316 @default.
• W4295809076 creator A5008513324 @default.
• W4295809076 creator A5008639202 @default.
• W4295809076 creator A5029084688 @default.
• W4295809076 creator A5061521167 @default.
• W4295809076 creator A5062240111 @default.
• W4295809076 creator A5064344998 @default.
• W4295809076 creator A5077467339 @default.
• W4295809076 creator A5078365001 @default.
• W4295809076 creator A5084346989 @default.
• W4295809076 date "2022-09-14" @default.
• W4295809076 modified "2023-09-28" @default.
• W4295809076 title "Identification of glycogene signature as a tool to predict the clinical outcome and immunotherapy response in breast cancer" @default.
• W4295809076 cites W1182461782 @default.
• W4295809076 cites W1985987855 @default.
• W4295809076 cites W1993222357 @default.
• W4295809076 cites W2032507799 @default.
• W4295809076 cites W2123879591 @default.
• W4295809076 cites W2126195886 @default.
• W4295809076 cites W2130430382 @default.
• W4295809076 cites W2134510529 @default.
• W4295809076 cites W2171521392 @default.
• W4295809076 cites W2186664119 @default.
• W4295809076 cites W2523290953 @default.
• W4295809076 cites W2587612578 @default.
• W4295809076 cites W2595917956 @default.
• W4295809076 cites W2734403713 @default.
• W4295809076 cites W2782930756 @default.
• W4295809076 cites W2787237920 @default.
• W4295809076 cites W2800266313 @default.
• W4295809076 cites W2909292083 @default.
• W4295809076 cites W2912993657 @default.
• W4295809076 cites W2943180760 @default.
• W4295809076 cites W2953013607 @default.
• W4295809076 cites W2960011166 @default.
• W4295809076 cites W2977196766 @default.
• W4295809076 cites W3022878707 @default.
• W4295809076 cites W3045996369 @default.
• W4295809076 cites W3082328420 @default.
• W4295809076 cites W3089992054 @default.
• W4295809076 cites W3101436145 @default.
• W4295809076 cites W3111471842 @default.
• W4295809076 cites W3112742208 @default.
• W4295809076 cites W3119005666 @default.
• W4295809076 cites W3121179405 @default.
• W4295809076 cites W3130319204 @default.
• W4295809076 cites W3160073845 @default.
• W4295809076 cites W3163977479 @default.
• W4295809076 cites W3164665275 @default.
• W4295809076 cites W3165303778 @default.
• W4295809076 cites W3173705400 @default.
• W4295809076 cites W3175173749 @default.
• W4295809076 cites W3186059675 @default.
• W4295809076 cites W3187495775 @default.
• W4295809076 cites W3190542965 @default.
• W4295809076 cites W3190709983 @default.
• W4295809076 cites W4200001714 @default.
• W4295809076 cites W4200355249 @default.
• W4295809076 cites W4205724345 @default.
• W4295809076 cites W4211005384 @default.
• W4295809076 cites W4211032970 @default.
• W4295809076 cites W4284895135 @default.
• W4295809076 cites W4285083526 @default.
• W4295809076 doi "https://doi.org/10.3389/fonc.2022.854284" @default.
• W4295809076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36185271" @default.
• W4295809076 hasPublicationYear "2022" @default.
• W4295809076 type Work @default.
• W4295809076 citedByCount "2" @default.
• W4295809076 countsByYear W42958090762023 @default.
• W4295809076 crossrefType "journal-article" @default.
• W4295809076 hasAuthorship W4295809076A5002050316 @default.
• W4295809076 hasAuthorship W4295809076A5008513324 @default.
• W4295809076 hasAuthorship W4295809076A5008639202 @default.
• W4295809076 hasAuthorship W4295809076A5029084688 @default.
• W4295809076 hasAuthorship W4295809076A5061521167 @default.
• W4295809076 hasAuthorship W4295809076A5062240111 @default.
• W4295809076 hasAuthorship W4295809076A5064344998 @default.
• W4295809076 hasAuthorship W4295809076A5077467339 @default.
• W4295809076 hasAuthorship W4295809076A5078365001 @default.
• W4295809076 hasAuthorship W4295809076A5084346989 @default.
• W4295809076 hasBestOaLocation W42958090761 @default.
• W4295809076 hasConcept C121608353 @default.
• W4295809076 hasConcept C126322002 @default.
• W4295809076 hasConcept C143998085 @default.
• W4295809076 hasConcept C167672396 @default.
• W4295809076 hasConcept C203014093 @default.
• W4295809076 hasConcept C2777701055 @default.
• W4295809076 hasConcept C502942594 @default.
• W4295809076 hasConcept C50382708 @default.
• W4295809076 hasConcept C530470458 @default.
• W4295809076 hasConcept C71924100 @default.
• W4295809076 hasConcept C86803240 @default.
• W4295809076 hasConcept C8891405 @default.
• W4295809076 hasConceptScore W4295809076C121608353 @default.
• W4295809076 hasConceptScore W4295809076C126322002 @default.
• W4295809076 hasConceptScore W4295809076C143998085 @default.
• W4295809076 hasConceptScore W4295809076C167672396 @default.
• W4295809076 hasConceptScore W4295809076C203014093 @default.

• next