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- W4295809602 abstract "Many people living with dementia and cognitive impairment have dysfunctional mitochondrial and insulin-glucose metabolism resembling type 2 diabetes mellitus and old age. Evidence from human trials shows that nutritional interventions and anti-diabetic medicines that target nutrient-sensing pathways overcome these deficits in glucose and energy metabolism and can improve cognition and/or reduce symptoms of dementia. The liver is the main organ that mediates the systemic effects of diets and many diabetic medicines; therefore, it is an intermediate target for such dementia interventions. A challenge is the efficacy of these treatments in older age. Solutions include the targeted hepatic delivery of diabetic medicines using nanotechnologies and titration of macronutrients to optimize hepatic energy metabolism." @default.
- W4295809602 created "2022-09-15" @default.
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- W4295809602 creator A5075013089 @default.
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- W4295809602 creator A5086295584 @default.
- W4295809602 date "2022-11-01" @default.
- W4295809602 modified "2023-10-17" @default.
- W4295809602 title "Targeting the liver in dementia and cognitive impairment: Dietary macronutrients and diabetic therapeutics" @default.
- W4295809602 cites W1493986974 @default.
- W4295809602 cites W1495872645 @default.
- W4295809602 cites W1522806115 @default.
- W4295809602 cites W1527910050 @default.
- W4295809602 cites W1543788907 @default.
- W4295809602 cites W1578034565 @default.
- W4295809602 cites W1893987280 @default.
- W4295809602 cites W193473937 @default.
- W4295809602 cites W1944664289 @default.
- W4295809602 cites W1970779072 @default.
- W4295809602 cites W1972366194 @default.
- W4295809602 cites W1972609075 @default.
- W4295809602 cites W1975959567 @default.
- W4295809602 cites W1976467306 @default.
- W4295809602 cites W1976619844 @default.
- W4295809602 cites W1977548021 @default.
- W4295809602 cites W1989199068 @default.
- W4295809602 cites W1989674299 @default.
- W4295809602 cites W1994181115 @default.
- W4295809602 cites W1997822484 @default.
- W4295809602 cites W2003845745 @default.
- W4295809602 cites W2005481412 @default.
- W4295809602 cites W2007047564 @default.
- W4295809602 cites W2021123891 @default.
- W4295809602 cites W2026468401 @default.
- W4295809602 cites W2027272551 @default.
- W4295809602 cites W2030089671 @default.
- W4295809602 cites W2030270894 @default.
- W4295809602 cites W2031773477 @default.
- W4295809602 cites W2045849794 @default.
- W4295809602 cites W2047509507 @default.
- W4295809602 cites W2050970964 @default.
- W4295809602 cites W2052226124 @default.
- W4295809602 cites W2059278059 @default.
- W4295809602 cites W2060170946 @default.
- W4295809602 cites W2062560800 @default.
- W4295809602 cites W2066232800 @default.
- W4295809602 cites W2069158867 @default.
- W4295809602 cites W2069306070 @default.
- W4295809602 cites W2072062185 @default.
- W4295809602 cites W2073438076 @default.
- W4295809602 cites W2076725316 @default.
- W4295809602 cites W2080015119 @default.
- W4295809602 cites W2083337622 @default.
- W4295809602 cites W2085251092 @default.
- W4295809602 cites W2086693995 @default.
- W4295809602 cites W2087281430 @default.
- W4295809602 cites W2087443596 @default.
- W4295809602 cites W2087497084 @default.
- W4295809602 cites W2096407545 @default.
- W4295809602 cites W2096629629 @default.
- W4295809602 cites W2096782516 @default.
- W4295809602 cites W2097150315 @default.
- W4295809602 cites W2097676935 @default.
- W4295809602 cites W2100397515 @default.
- W4295809602 cites W2103440561 @default.
- W4295809602 cites W2106792243 @default.
- W4295809602 cites W2109527205 @default.
- W4295809602 cites W2113815647 @default.
- W4295809602 cites W2120934226 @default.
- W4295809602 cites W2124536609 @default.
- W4295809602 cites W2125368074 @default.
- W4295809602 cites W2125618313 @default.
- W4295809602 cites W2126774214 @default.
- W4295809602 cites W2130693276 @default.
- W4295809602 cites W2132539868 @default.
- W4295809602 cites W2135591161 @default.
- W4295809602 cites W2136063682 @default.
- W4295809602 cites W2140346370 @default.
- W4295809602 cites W2140822113 @default.
- W4295809602 cites W2147044753 @default.
- W4295809602 cites W2149369886 @default.
- W4295809602 cites W2150472993 @default.
- W4295809602 cites W2151417525 @default.
- W4295809602 cites W2151697734 @default.
- W4295809602 cites W2153249592 @default.
- W4295809602 cites W2153284686 @default.
- W4295809602 cites W2156080804 @default.
- W4295809602 cites W2158197541 @default.
- W4295809602 cites W2158381042 @default.
- W4295809602 cites W2158728639 @default.
- W4295809602 cites W2159484834 @default.
- W4295809602 cites W2160427616 @default.
- W4295809602 cites W2168769697 @default.
- W4295809602 cites W2189133141 @default.
- W4295809602 cites W2212795645 @default.
- W4295809602 cites W2216147182 @default.