Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295816688> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W4295816688 endingPage "S667" @default.
- W4295816688 startingPage "S666" @default.
- W4295816688 abstract "Gliomas are the most common primary brain tumors, but there are currently many limitations for the implementation of liquid biopsy in this disease. Cerebrospinal fluid (CSF) is emerging as the most reliable reservoir for ctDNA analysis, although evidence is still limited. Prospective study of patients with gliomas diagnosed at Hospital Clinico Universitario San Carlos and Hospital Universitario La Paz (Madrid, Spain). High throughput next generation sequencing (NGS) using a customized gene panel (Illumina, Inc.) of 8 genes (IDH1, IDH2, ATRX, TP53, PTEN, PIK3CA, EGFR, BRAF) was used in paired CSF and FFPE and/or fresh tumor samples, and run in an Illumina Miseq instrument (Illumina, Inc.). Only confirmed pathogenic mutations were considered as valid and are reported here. Mutation concordance occurred when the same pathogenic gene variants were detected in tumor and CSF. Between February 2017 and March 2020, 31 glioma patients (pts) were enrolled in which 2-5 ml of CSF were collected intraoperatively prior to surgical manipulation of the tumor. M:F ratio: 22:9. Median age 51 (Min-Max: 20-78). CSF collected at new diagnosis (n=22); relapse (n=9). WHO 5th Ed: IDHMUT astrocytoma (n=9), IDHMUT oligodendroglioma (n=6), IDHWT glioblastoma (n=16). CSF-ctDNA-positive: 18/31 (58%). CSF-ctDNA-negative: 13/31 (42%). No. of mutations in CSF: 1 (9/18), 2 (7/18), 3 (2/18). Frequency of CSF-ctDNA mutated genes: EGFR (8/18: 44%), PTEN (7/18: 39%), TP53 (6/18: 33%), IDH1 (4/18: 22%), PIK3CA (4/18: 22%). Tumor-CSF mutation concordance: 15/18 (83%). After a median follow-up since CSF collection of 20 months (m) (Min-Max: 0-57), median OS was not reached (NR) (95%CI NR-NR). No correlation was found between detection of ctDNA in CSF and distance from closest CSF reservoir, tumor size or IDH status. CSF is a reliable reservoir for ctDNA analyses in patients with gliomas. Larger, prospective studies should be conducted in order to refine the potential role of liquid biopsy in this disease." @default.
- W4295816688 created "2022-09-15" @default.
- W4295816688 creator A5012278825 @default.
- W4295816688 creator A5016669559 @default.
- W4295816688 creator A5025642194 @default.
- W4295816688 creator A5050079233 @default.
- W4295816688 creator A5065542352 @default.
- W4295816688 creator A5069385617 @default.
- W4295816688 creator A5070615926 @default.
- W4295816688 creator A5071131374 @default.
- W4295816688 creator A5071177194 @default.
- W4295816688 creator A5075783894 @default.
- W4295816688 date "2022-09-01" @default.
- W4295816688 modified "2023-10-16" @default.
- W4295816688 title "279O ctDNA detection in cerebrospinal fluid and concordance with the primary tumor in a multicenter prospective study of patients with glioma" @default.
- W4295816688 doi "https://doi.org/10.1016/j.annonc.2022.07.413" @default.
- W4295816688 hasPublicationYear "2022" @default.
- W4295816688 type Work @default.
- W4295816688 citedByCount "0" @default.
- W4295816688 crossrefType "journal-article" @default.
- W4295816688 hasAuthorship W4295816688A5012278825 @default.
- W4295816688 hasAuthorship W4295816688A5016669559 @default.
- W4295816688 hasAuthorship W4295816688A5025642194 @default.
- W4295816688 hasAuthorship W4295816688A5050079233 @default.
- W4295816688 hasAuthorship W4295816688A5065542352 @default.
- W4295816688 hasAuthorship W4295816688A5069385617 @default.
- W4295816688 hasAuthorship W4295816688A5070615926 @default.
- W4295816688 hasAuthorship W4295816688A5071131374 @default.
- W4295816688 hasAuthorship W4295816688A5071177194 @default.
- W4295816688 hasAuthorship W4295816688A5075783894 @default.
- W4295816688 hasConcept C104317684 @default.
- W4295816688 hasConcept C126322002 @default.
- W4295816688 hasConcept C127848430 @default.
- W4295816688 hasConcept C142724271 @default.
- W4295816688 hasConcept C143998085 @default.
- W4295816688 hasConcept C160798450 @default.
- W4295816688 hasConcept C188816634 @default.
- W4295816688 hasConcept C190283241 @default.
- W4295816688 hasConcept C2776689207 @default.
- W4295816688 hasConcept C2777609662 @default.
- W4295816688 hasConcept C2777931997 @default.
- W4295816688 hasConcept C2778227246 @default.
- W4295816688 hasConcept C2778880634 @default.
- W4295816688 hasConcept C2779130545 @default.
- W4295816688 hasConcept C2779651940 @default.
- W4295816688 hasConcept C501734568 @default.
- W4295816688 hasConcept C502942594 @default.
- W4295816688 hasConcept C54355233 @default.
- W4295816688 hasConcept C71924100 @default.
- W4295816688 hasConcept C86554907 @default.
- W4295816688 hasConcept C86803240 @default.
- W4295816688 hasConceptScore W4295816688C104317684 @default.
- W4295816688 hasConceptScore W4295816688C126322002 @default.
- W4295816688 hasConceptScore W4295816688C127848430 @default.
- W4295816688 hasConceptScore W4295816688C142724271 @default.
- W4295816688 hasConceptScore W4295816688C143998085 @default.
- W4295816688 hasConceptScore W4295816688C160798450 @default.
- W4295816688 hasConceptScore W4295816688C188816634 @default.
- W4295816688 hasConceptScore W4295816688C190283241 @default.
- W4295816688 hasConceptScore W4295816688C2776689207 @default.
- W4295816688 hasConceptScore W4295816688C2777609662 @default.
- W4295816688 hasConceptScore W4295816688C2777931997 @default.
- W4295816688 hasConceptScore W4295816688C2778227246 @default.
- W4295816688 hasConceptScore W4295816688C2778880634 @default.
- W4295816688 hasConceptScore W4295816688C2779130545 @default.
- W4295816688 hasConceptScore W4295816688C2779651940 @default.
- W4295816688 hasConceptScore W4295816688C501734568 @default.
- W4295816688 hasConceptScore W4295816688C502942594 @default.
- W4295816688 hasConceptScore W4295816688C54355233 @default.
- W4295816688 hasConceptScore W4295816688C71924100 @default.
- W4295816688 hasConceptScore W4295816688C86554907 @default.
- W4295816688 hasConceptScore W4295816688C86803240 @default.
- W4295816688 hasLocation W42958166881 @default.
- W4295816688 hasOpenAccess W4295816688 @default.
- W4295816688 hasPrimaryLocation W42958166881 @default.
- W4295816688 hasRelatedWork W1964609356 @default.
- W4295816688 hasRelatedWork W2334083107 @default.
- W4295816688 hasRelatedWork W2604606623 @default.
- W4295816688 hasRelatedWork W2996542976 @default.
- W4295816688 hasRelatedWork W3013369088 @default.
- W4295816688 hasRelatedWork W3153451669 @default.
- W4295816688 hasRelatedWork W4213059323 @default.
- W4295816688 hasRelatedWork W4285285281 @default.
- W4295816688 hasRelatedWork W4312209937 @default.
- W4295816688 hasRelatedWork W4379508315 @default.
- W4295816688 hasVolume "33" @default.
- W4295816688 isParatext "false" @default.
- W4295816688 isRetracted "false" @default.
- W4295816688 workType "article" @default.