FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295817708> ?p ?o ?g. }

• W4295817708 endingPage "S1039" @default.
• W4295817708 startingPage "S1038" @default.
• W4295817708 abstract "KRAS gene is mutated in about 30% non-small cell lung cancer (NSCLC). Immune checkpoint inhibitors (ICIs) have been applied widely and KRAS mutations were considered to be related to superior clinical response. However, several studies revealed that co-mutated driver genes such as TP53, STK11 would impact the therapy effects. G12 is the most frequent KRAS mutated dot in NSCLC. The co-mutational status with driver genes in different G12 subtypes have not been fully explored. 903 cases of Chinese NCSLC patients were included in our analysis. Immunohistochemistry and 381-gene panel next-generation sequencing (NGS) testing had been performed in their tumor tissue specimen. PD-L1 expression level was evaluated by the tumor positive score (TPS). Tumor mutational burden (TMB) status were evaluated via NGS testing. G12C/D/V/A/R/S/F/L/I/Y were detected but only G12C/D/V/A showed mutational rates above 5%. The number of cases were 294 (32.6%), 143 (15.8%), 157 (17.4%), 81 (9%) in G12C/D/V/A, separately. These four G12 subtypes were basically mutually exclusively, except 52 cases (6%) had 2 or 3 subtypes. The mutational rates of G12C/D/V/A in TP53, LRP1B, STK11 and KEAP1-mutated patients were balanced, with the G12C were co-occurred most in KEAP1-mutated group (58.2%), G12D were co-occurred most in STK11-mutated group (19.6%). Compared to other KRAS-mutated cases, G12-mutated had similar TMB levels. In 546 cases with TPS data, 62% in G12C-mutated group were TPS>1% while only 45% in G12V-mutated group were TPS>1%. According to the TCGA NSCLC cohort, there was no significant difference in overall survival between these subtypes, whether co-mutated with TP53/LRP1B/STK11/KEAP1 or not. In Chinese NSCLC, the main KRAS G12 subtypes were G12C/D/V/A and G12C was the most frequent. KRAS G12C-mutated NSCLC were most probable to co-mutate with KEAP1 gene, and have relative high PD-L1 expression. G12C/D/V/A had little effect on TMB and had no effect on OS of early lung cancer." @default.
• W4295817708 created "2022-09-15" @default.
• W4295817708 creator A5006130341 @default.
• W4295817708 creator A5012092981 @default.
• W4295817708 creator A5018351363 @default.
• W4295817708 creator A5026267996 @default.
• W4295817708 creator A5058461089 @default.
• W4295817708 creator A5061852661 @default.
• W4295817708 creator A5067824686 @default.
• W4295817708 date "2022-09-01" @default.
• W4295817708 modified "2023-09-27" @default.
• W4295817708 title "1059P KRAS G12 subtypes with co-mutated TP53, LRP1B, STK11, KEAP1 in lung cancer and their impact on TMB levels, PD-L1 expression and overall survival" @default.
• W4295817708 doi "https://doi.org/10.1016/j.annonc.2022.07.1185" @default.
• W4295817708 hasPublicationYear "2022" @default.
• W4295817708 type Work @default.
• W4295817708 citedByCount "0" @default.
• W4295817708 crossrefType "journal-article" @default.
• W4295817708 hasAuthorship W4295817708A5006130341 @default.
• W4295817708 hasAuthorship W4295817708A5012092981 @default.
• W4295817708 hasAuthorship W4295817708A5018351363 @default.
• W4295817708 hasAuthorship W4295817708A5026267996 @default.
• W4295817708 hasAuthorship W4295817708A5058461089 @default.
• W4295817708 hasAuthorship W4295817708A5061852661 @default.
• W4295817708 hasAuthorship W4295817708A5067824686 @default.
• W4295817708 hasConcept C104317684 @default.
• W4295817708 hasConcept C121608353 @default.
• W4295817708 hasConcept C126322002 @default.
• W4295817708 hasConcept C143998085 @default.
• W4295817708 hasConcept C204232928 @default.
• W4295817708 hasConcept C2776256026 @default.
• W4295817708 hasConcept C2777983448 @default.
• W4295817708 hasConcept C2781187634 @default.
• W4295817708 hasConcept C502942594 @default.
• W4295817708 hasConcept C526805850 @default.
• W4295817708 hasConcept C54355233 @default.
• W4295817708 hasConcept C71924100 @default.
• W4295817708 hasConcept C86803240 @default.
• W4295817708 hasConceptScore W4295817708C104317684 @default.
• W4295817708 hasConceptScore W4295817708C121608353 @default.
• W4295817708 hasConceptScore W4295817708C126322002 @default.
• W4295817708 hasConceptScore W4295817708C143998085 @default.
• W4295817708 hasConceptScore W4295817708C204232928 @default.
• W4295817708 hasConceptScore W4295817708C2776256026 @default.
• W4295817708 hasConceptScore W4295817708C2777983448 @default.
• W4295817708 hasConceptScore W4295817708C2781187634 @default.
• W4295817708 hasConceptScore W4295817708C502942594 @default.
• W4295817708 hasConceptScore W4295817708C526805850 @default.
• W4295817708 hasConceptScore W4295817708C54355233 @default.
• W4295817708 hasConceptScore W4295817708C71924100 @default.
• W4295817708 hasConceptScore W4295817708C86803240 @default.
• W4295817708 hasLocation W42958177081 @default.
• W4295817708 hasOpenAccess W4295817708 @default.
• W4295817708 hasPrimaryLocation W42958177081 @default.
• W4295817708 hasRelatedWork W2057223714 @default.
• W4295817708 hasRelatedWork W2390152934 @default.
• W4295817708 hasRelatedWork W2547499110 @default.
• W4295817708 hasRelatedWork W2944810278 @default.
• W4295817708 hasRelatedWork W3178446744 @default.
• W4295817708 hasRelatedWork W4244606352 @default.
• W4295817708 hasRelatedWork W4295817708 @default.
• W4295817708 hasRelatedWork W4307907988 @default.
• W4295817708 hasRelatedWork W4318575236 @default.
• W4295817708 hasRelatedWork W4361824030 @default.
• W4295817708 hasVolume "33" @default.
• W4295817708 isParatext "false" @default.
• W4295817708 isRetracted "false" @default.
• W4295817708 workType "article" @default.