FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295861567> ?p ?o ?g. }

• W4295861567 abstract "Current methods for the diagnosis and monitoring of bladder cancer are invasive and have suboptimal sensitivity. Liquid biopsy as a non-invasive approach has been capturing attentions recently. To explore the ability of urine-based liquid biopsy in detecting and monitoring genitourinary tumors, we developed a method based on promoter-targeted DNA methylation of urine sediment DNA. We used samples from a primary bladder cancer cohort (n=40) and a healthy cohort (n=40) to train a model and obtained an integrated area under the curve (AUC) > 0.96 in the 10-fold cross-validation, which demonstrated the ability of our method for detecting bladder cancer from the healthy. We next validated the model with samples from a recurrent cohort (n=21) and a non-recurrent cohort (n=19) and obtained an AUC > 0.91, which demonstrated the ability of our model in monitoring the progress of bladder cancer. Moreover, 80% (4/5) of samples from patients with benign urothelial diseases had been considered to be healthy sample rather than cancer sample, preliminarily demonstrating the potential of distinguishing benign urothelial diseases from cancer. Further analysis basing on multiple-time point sampling revealed that the cancer signal in 80% (4/5) patients had decreased as expected when they achieved the recurrent-free state. All the results suggested that our method is a promising approach for noninvasive detection and prognostic monitoring of bladder cancer." @default.
• W4295861567 created "2022-09-15" @default.
• W4295861567 creator A5011394303 @default.
• W4295861567 creator A5015297358 @default.
• W4295861567 creator A5025202016 @default.
• W4295861567 creator A5029039334 @default.
• W4295861567 creator A5032960977 @default.
• W4295861567 creator A5039241237 @default.
• W4295861567 creator A5045355349 @default.
• W4295861567 creator A5053104107 @default.
• W4295861567 creator A5063936933 @default.
• W4295861567 creator A5068593113 @default.
• W4295861567 creator A5072535717 @default.
• W4295861567 creator A5073216396 @default.
• W4295861567 creator A5073688692 @default.
• W4295861567 date "2022-09-07" @default.
• W4295861567 modified "2023-10-18" @default.
• W4295861567 title "Detecting and monitoring bladder cancer with exfoliated cells in urine" @default.
• W4295861567 cites W118827870 @default.
• W4295861567 cites W1497011653 @default.
• W4295861567 cites W1578450780 @default.
• W4295861567 cites W1586564421 @default.
• W4295861567 cites W1596875459 @default.
• W4295861567 cites W1912311013 @default.
• W4295861567 cites W1964321121 @default.
• W4295861567 cites W1965262464 @default.
• W4295861567 cites W1968328969 @default.
• W4295861567 cites W1974295405 @default.
• W4295861567 cites W2002536774 @default.
• W4295861567 cites W2003402014 @default.
• W4295861567 cites W2004218269 @default.
• W4295861567 cites W2004256856 @default.
• W4295861567 cites W2010509698 @default.
• W4295861567 cites W2013364403 @default.
• W4295861567 cites W2015946977 @default.
• W4295861567 cites W2020942608 @default.
• W4295861567 cites W2022957119 @default.
• W4295861567 cites W2032977648 @default.
• W4295861567 cites W2033278321 @default.
• W4295861567 cites W2033521255 @default.
• W4295861567 cites W2036279217 @default.
• W4295861567 cites W2039320151 @default.
• W4295861567 cites W2041046276 @default.
• W4295861567 cites W2042177623 @default.
• W4295861567 cites W2043311748 @default.
• W4295861567 cites W2058815850 @default.
• W4295861567 cites W2060248916 @default.
• W4295861567 cites W2061805562 @default.
• W4295861567 cites W2064361523 @default.
• W4295861567 cites W2070568348 @default.
• W4295861567 cites W2071661874 @default.
• W4295861567 cites W2073123191 @default.
• W4295861567 cites W2089373036 @default.
• W4295861567 cites W2095682420 @default.
• W4295861567 cites W2103758589 @default.
• W4295861567 cites W2110751022 @default.
• W4295861567 cites W2123174009 @default.
• W4295861567 cites W2127081952 @default.
• W4295861567 cites W2137505881 @default.
• W4295861567 cites W2142806155 @default.
• W4295861567 cites W2145975061 @default.
• W4295861567 cites W2155488525 @default.
• W4295861567 cites W2163494229 @default.
• W4295861567 cites W2168029077 @default.
• W4295861567 cites W2225287204 @default.
• W4295861567 cites W2315914439 @default.
• W4295861567 cites W2466305252 @default.
• W4295861567 cites W2511558499 @default.
• W4295861567 cites W2547792410 @default.
• W4295861567 cites W2567496810 @default.
• W4295861567 cites W2568815887 @default.
• W4295861567 cites W2583233430 @default.
• W4295861567 cites W2604685034 @default.
• W4295861567 cites W2734508763 @default.
• W4295861567 cites W2768402949 @default.
• W4295861567 cites W2774072836 @default.
• W4295861567 cites W2886270318 @default.
• W4295861567 cites W2889646458 @default.
• W4295861567 cites W2896519456 @default.
• W4295861567 cites W2896627116 @default.
• W4295861567 cites W2897635533 @default.
• W4295861567 cites W2906216049 @default.
• W4295861567 cites W2947179237 @default.
• W4295861567 cites W2998739009 @default.
• W4295861567 cites W3044926932 @default.
• W4295861567 cites W3087414372 @default.
• W4295861567 cites W3092414526 @default.
• W4295861567 cites W4220831425 @default.
• W4295861567 cites W4232250219 @default.
• W4295861567 cites W4236851222 @default.
• W4295861567 cites W4247421062 @default.
• W4295861567 cites W4248754259 @default.
• W4295861567 cites W2144882472 @default.
• W4295861567 doi "https://doi.org/10.3389/fonc.2022.986692" @default.
• W4295861567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36158668" @default.
• W4295861567 hasPublicationYear "2022" @default.
• W4295861567 type Work @default.
• W4295861567 citedByCount "0" @default.
• W4295861567 crossrefType "journal-article" @default.
• W4295861567 hasAuthorship W4295861567A5011394303 @default.

• next