Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295872902> ?p ?o ?g. }
- W4295872902 endingPage "136" @default.
- W4295872902 startingPage "128" @default.
- W4295872902 abstract "The related genetic variants of tau deposition, a seminal pathological hallmark of Alzheimer's disease, remain poorly understood. We sought to perform a genome-wide association study of brain tau load as measured by AV1451 positron emission tomography (PET). Among 543 non-demented European individuals, novel associations with higher tau were identified for rs56298435 (p = 8.35 × 10−10, β=0.31) within ZBTB20, and for rs150532 (p = 1.90 × 10−8, β=0.26) in the protein phosphorylation regulatory gene EYA4. The APOE association additionally reached genome-wide significant when APOE ε4 was not adjusted. Minor allele carriers of rs56298435 or rs150532 showed higher levels of tau PET load. As expected, phosphorylated-tau analyses in both plasma and cerebrospinal fluid also revealed the same direction of effect. Functionally, the effects of novel loci on cognitive decline could be mediated by tau pathology. In addition, we observed that the expression of VNN2 as regulated by rs150532, together with EYA4, displayed significant correlations with the tau-related gene MAPT in numerous brain regions. Our novel finding lends additional credence to heritable underpinnings of tau deposition." @default.
- W4295872902 created "2022-09-15" @default.
- W4295872902 creator A5005417134 @default.
- W4295872902 creator A5035858548 @default.
- W4295872902 creator A5043382324 @default.
- W4295872902 creator A5055536407 @default.
- W4295872902 creator A5066444153 @default.
- W4295872902 creator A5069785794 @default.
- W4295872902 creator A5079648202 @default.
- W4295872902 creator A5087310518 @default.
- W4295872902 date "2022-12-01" @default.
- W4295872902 modified "2023-10-01" @default.
- W4295872902 title "Genome-wide association study of brain tau deposition as measured by 18F-flortaucipir positron emission tomography imaging" @default.
- W4295872902 cites W1513705457 @default.
- W4295872902 cites W1532339612 @default.
- W4295872902 cites W1552434751 @default.
- W4295872902 cites W1607181948 @default.
- W4295872902 cites W1769834772 @default.
- W4295872902 cites W1963919142 @default.
- W4295872902 cites W1967958649 @default.
- W4295872902 cites W1969874328 @default.
- W4295872902 cites W2008301592 @default.
- W4295872902 cites W2018880103 @default.
- W4295872902 cites W2018976354 @default.
- W4295872902 cites W2033151532 @default.
- W4295872902 cites W2070919286 @default.
- W4295872902 cites W2101489286 @default.
- W4295872902 cites W2113595844 @default.
- W4295872902 cites W2114226569 @default.
- W4295872902 cites W2124341714 @default.
- W4295872902 cites W2145796722 @default.
- W4295872902 cites W2153754152 @default.
- W4295872902 cites W2157439965 @default.
- W4295872902 cites W2160597466 @default.
- W4295872902 cites W2166207589 @default.
- W4295872902 cites W2166536611 @default.
- W4295872902 cites W2167141135 @default.
- W4295872902 cites W2171346860 @default.
- W4295872902 cites W2175730819 @default.
- W4295872902 cites W2181472449 @default.
- W4295872902 cites W2183091920 @default.
- W4295872902 cites W2188707104 @default.
- W4295872902 cites W2322136670 @default.
- W4295872902 cites W2529649944 @default.
- W4295872902 cites W2572445651 @default.
- W4295872902 cites W2590870875 @default.
- W4295872902 cites W2593636852 @default.
- W4295872902 cites W2607046971 @default.
- W4295872902 cites W2775437905 @default.
- W4295872902 cites W2802041929 @default.
- W4295872902 cites W2802157723 @default.
- W4295872902 cites W2888540773 @default.
- W4295872902 cites W2897809390 @default.
- W4295872902 cites W2909883195 @default.
- W4295872902 cites W2922449325 @default.
- W4295872902 cites W2933437893 @default.
- W4295872902 cites W2936845860 @default.
- W4295872902 cites W2981788116 @default.
- W4295872902 cites W3009270039 @default.
- W4295872902 cites W3012358770 @default.
- W4295872902 cites W3020537948 @default.
- W4295872902 cites W3080588227 @default.
- W4295872902 cites W3173227218 @default.
- W4295872902 doi "https://doi.org/10.1016/j.neurobiolaging.2022.09.002" @default.
- W4295872902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36195041" @default.
- W4295872902 hasPublicationYear "2022" @default.
- W4295872902 type Work @default.
- W4295872902 citedByCount "1" @default.
- W4295872902 countsByYear W42958729022023 @default.
- W4295872902 crossrefType "journal-article" @default.
- W4295872902 hasAuthorship W4295872902A5005417134 @default.
- W4295872902 hasAuthorship W4295872902A5035858548 @default.
- W4295872902 hasAuthorship W4295872902A5043382324 @default.
- W4295872902 hasAuthorship W4295872902A5055536407 @default.
- W4295872902 hasAuthorship W4295872902A5066444153 @default.
- W4295872902 hasAuthorship W4295872902A5069785794 @default.
- W4295872902 hasAuthorship W4295872902A5079648202 @default.
- W4295872902 hasAuthorship W4295872902A5087310518 @default.
- W4295872902 hasConcept C104317684 @default.
- W4295872902 hasConcept C106208931 @default.
- W4295872902 hasConcept C135763542 @default.
- W4295872902 hasConcept C142724271 @default.
- W4295872902 hasConcept C153209595 @default.
- W4295872902 hasConcept C15744967 @default.
- W4295872902 hasConcept C169760540 @default.
- W4295872902 hasConcept C180754005 @default.
- W4295872902 hasConcept C199374082 @default.
- W4295872902 hasConcept C2775842073 @default.
- W4295872902 hasConcept C2778373026 @default.
- W4295872902 hasConcept C2778670691 @default.
- W4295872902 hasConcept C2779134260 @default.
- W4295872902 hasConcept C2779651940 @default.
- W4295872902 hasConcept C2781073650 @default.
- W4295872902 hasConcept C502032728 @default.
- W4295872902 hasConcept C54355233 @default.
- W4295872902 hasConcept C57089818 @default.
- W4295872902 hasConcept C58693492 @default.
- W4295872902 hasConcept C71924100 @default.