FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295876072> ?p ?o ?g. }

• W4295876072 abstract "Somatic variants act as critical players during cancer occurrence and development. Thus, an accurate and robust method to identify them is the foundation of cutting-edge cancer genome research. However, due to low accessibility and high individual-/sample-specificity of the somatic variants in tumor samples, the detection is, to date, still crammed with challenges, particularly when lacking paired normal samples as control. To solve this burning issue, we developed a tumor-only somatic and germline variant identification method (TSomVar) using the random forest algorithm established on sample-specific variant datasets derived from genotype imputation, reads-mapping level annotation and functional annotation. We trained TSomVar by using genomic variant datasets of three major cancer types: colorectal cancer, hepatocellular carcinoma and skin cutaneous melanoma. Compared with existing tumor-only somatic variant identification tools, TSomVar shows excellent performances in somatic variant detection with higher accuracy and better capability of recalling for test datasets from colorectal cancer and skin cutaneous melanoma. In addition, TSomVar is equipped with the competence of accurately identifying germline variants in tumor samples. Taken together, TSomVar will undoubtedly facilitate and revolutionize somatic variant explorations in cancer research." @default.
• W4295876072 created "2022-09-15" @default.
• W4295876072 creator A5007855766 @default.
• W4295876072 creator A5009289581 @default.
• W4295876072 creator A5009761974 @default.
• W4295876072 creator A5015195367 @default.
• W4295876072 creator A5027994753 @default.
• W4295876072 creator A5049341927 @default.
• W4295876072 creator A5051558011 @default.
• W4295876072 creator A5055558063 @default.
• W4295876072 creator A5064014860 @default.
• W4295876072 creator A5067876051 @default.
• W4295876072 creator A5069720699 @default.
• W4295876072 creator A5088975859 @default.
• W4295876072 date "2022-09-01" @default.
• W4295876072 modified "2023-10-16" @default.
• W4295876072 title "TSomVar: a tumor-only somatic and germline variant identification method with random forest" @default.
• W4295876072 cites W1965857060 @default.
• W4295876072 cites W1984068087 @default.
• W4295876072 cites W2022102389 @default.
• W4295876072 cites W2044433401 @default.
• W4295876072 cites W2087036932 @default.
• W4295876072 cites W2101425604 @default.
• W4295876072 cites W2103441770 @default.
• W4295876072 cites W2104549677 @default.
• W4295876072 cites W2118151336 @default.
• W4295876072 cites W2119180969 @default.
• W4295876072 cites W2122732537 @default.
• W4295876072 cites W2138601221 @default.
• W4295876072 cites W2146290346 @default.
• W4295876072 cites W2149441684 @default.
• W4295876072 cites W2151794156 @default.
• W4295876072 cites W2153056550 @default.
• W4295876072 cites W2155943701 @default.
• W4295876072 cites W2164241627 @default.
• W4295876072 cites W2173732482 @default.
• W4295876072 cites W2202187342 @default.
• W4295876072 cites W2204695746 @default.
• W4295876072 cites W2299181842 @default.
• W4295876072 cites W2557981253 @default.
• W4295876072 cites W2566723262 @default.
• W4295876072 cites W2674532415 @default.
• W4295876072 cites W2759930271 @default.
• W4295876072 cites W2786268518 @default.
• W4295876072 cites W2794135466 @default.
• W4295876072 cites W2898789672 @default.
• W4295876072 cites W2911986997 @default.
• W4295876072 cites W2949202382 @default.
• W4295876072 cites W2952113787 @default.
• W4295876072 cites W2964894377 @default.
• W4295876072 cites W2996805586 @default.
• W4295876072 cites W3038956612 @default.
• W4295876072 cites W3111061871 @default.
• W4295876072 cites W3142571537 @default.
• W4295876072 cites W3184308115 @default.
• W4295876072 cites W3193380691 @default.
• W4295876072 cites W3208459100 @default.
• W4295876072 cites W3211014030 @default.
• W4295876072 cites W3214785274 @default.
• W4295876072 cites W3215751839 @default.
• W4295876072 cites W3216588755 @default.
• W4295876072 cites W4205247356 @default.
• W4295876072 cites W4247001379 @default.
• W4295876072 doi "https://doi.org/10.1093/bib/bbac381" @default.
• W4295876072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36088550" @default.
• W4295876072 hasPublicationYear "2022" @default.
• W4295876072 type Work @default.
• W4295876072 citedByCount "0" @default.
• W4295876072 crossrefType "journal-article" @default.
• W4295876072 hasAuthorship W4295876072A5007855766 @default.
• W4295876072 hasAuthorship W4295876072A5009289581 @default.
• W4295876072 hasAuthorship W4295876072A5009761974 @default.
• W4295876072 hasAuthorship W4295876072A5015195367 @default.
• W4295876072 hasAuthorship W4295876072A5027994753 @default.
• W4295876072 hasAuthorship W4295876072A5049341927 @default.
• W4295876072 hasAuthorship W4295876072A5051558011 @default.
• W4295876072 hasAuthorship W4295876072A5055558063 @default.
• W4295876072 hasAuthorship W4295876072A5064014860 @default.
• W4295876072 hasAuthorship W4295876072A5067876051 @default.
• W4295876072 hasAuthorship W4295876072A5069720699 @default.
• W4295876072 hasAuthorship W4295876072A5088975859 @default.
• W4295876072 hasConcept C104317684 @default.
• W4295876072 hasConcept C109825262 @default.
• W4295876072 hasConcept C116834253 @default.
• W4295876072 hasConcept C134305767 @default.
• W4295876072 hasConcept C13514818 @default.
• W4295876072 hasConcept C2776321320 @default.
• W4295876072 hasConcept C501734568 @default.
• W4295876072 hasConcept C54355233 @default.
• W4295876072 hasConcept C59822182 @default.
• W4295876072 hasConcept C70721500 @default.
• W4295876072 hasConcept C86803240 @default.
• W4295876072 hasConceptScore W4295876072C104317684 @default.
• W4295876072 hasConceptScore W4295876072C109825262 @default.
• W4295876072 hasConceptScore W4295876072C116834253 @default.
• W4295876072 hasConceptScore W4295876072C134305767 @default.
• W4295876072 hasConceptScore W4295876072C13514818 @default.
• W4295876072 hasConceptScore W4295876072C2776321320 @default.
• W4295876072 hasConceptScore W4295876072C501734568 @default.
• W4295876072 hasConceptScore W4295876072C54355233 @default.

• next