Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295905819> ?p ?o ?g. }
- W4295905819 endingPage "1038" @default.
- W4295905819 startingPage "1029" @default.
- W4295905819 abstract "Outcomes for patients with advanced cutaneous squamous cell carcinoma (cSCC) are poor, however recent approvals in programmed death-1 (PD-1) checkpoint inhibition have shown promise. Prior systemic treatments in this patient population included chemotherapy and anti-EGFR directed therapies, with limited long-term benefit. Studies investigating cemiplimab and pembrolizumab have recently revealed significant responses with many cases of sustained benefit in both locally advanced and recurrent and/or metastatic disease. While these treatments have shown improvement in outcomes, there are continued areas of need.This review focuses on clinical evidence for PD-1 directed checkpoint inhibition in advanced cSCC. Excluded populations and new approaches involving immunotherapy are discussed.Immune checkpoint inhibition in advanced cSCC has shown impressive benefit. The clinical trials for both cemiplimab and pembrolizumab demonstrate similar responses and outcomes. Biomarkers for predicting response are an area of need. In addition, these trials excluded immunosuppressed patients due to hematological malignancies or prior organ transplant, which are populations with significantly increased risk of cSCC. Finally, a variety of novel approaches using checkpoint inhibition in cSCC are being investigated, with some encouraging preliminary results." @default.
- W4295905819 created "2022-09-16" @default.
- W4295905819 creator A5017176613 @default.
- W4295905819 creator A5075324403 @default.
- W4295905819 date "2022-09-19" @default.
- W4295905819 modified "2023-09-26" @default.
- W4295905819 title "Pembrolizumab as monotherapy in locally advanced cutaneous squamous cell carcinoma" @default.
- W4295905819 cites W1508258462 @default.
- W4295905819 cites W1594237846 @default.
- W4295905819 cites W1964650964 @default.
- W4295905819 cites W1996398553 @default.
- W4295905819 cites W2004350912 @default.
- W4295905819 cites W2010080922 @default.
- W4295905819 cites W2016789384 @default.
- W4295905819 cites W2016983859 @default.
- W4295905819 cites W2030368586 @default.
- W4295905819 cites W2035748563 @default.
- W4295905819 cites W2040600853 @default.
- W4295905819 cites W2044554762 @default.
- W4295905819 cites W2066671159 @default.
- W4295905819 cites W2101157733 @default.
- W4295905819 cites W2118814022 @default.
- W4295905819 cites W2142745648 @default.
- W4295905819 cites W2155752258 @default.
- W4295905819 cites W2157466346 @default.
- W4295905819 cites W2163076565 @default.
- W4295905819 cites W2330274082 @default.
- W4295905819 cites W2380316500 @default.
- W4295905819 cites W2593714049 @default.
- W4295905819 cites W2594491432 @default.
- W4295905819 cites W2606495925 @default.
- W4295905819 cites W2761058867 @default.
- W4295905819 cites W2779221466 @default.
- W4295905819 cites W2782712404 @default.
- W4295905819 cites W2783137027 @default.
- W4295905819 cites W2784072458 @default.
- W4295905819 cites W2797943369 @default.
- W4295905819 cites W2805968856 @default.
- W4295905819 cites W2891486030 @default.
- W4295905819 cites W2899455839 @default.
- W4295905819 cites W2945590213 @default.
- W4295905819 cites W2946126594 @default.
- W4295905819 cites W2998989384 @default.
- W4295905819 cites W3006654174 @default.
- W4295905819 cites W3010839046 @default.
- W4295905819 cites W3030580179 @default.
- W4295905819 cites W3038010268 @default.
- W4295905819 cites W3043252982 @default.
- W4295905819 cites W3046607405 @default.
- W4295905819 cites W3087940107 @default.
- W4295905819 cites W3094421324 @default.
- W4295905819 cites W3111836013 @default.
- W4295905819 cites W3170964843 @default.
- W4295905819 cites W3173006630 @default.
- W4295905819 cites W3174756745 @default.
- W4295905819 cites W3184066167 @default.
- W4295905819 cites W3194196194 @default.
- W4295905819 cites W3201549363 @default.
- W4295905819 cites W3210251651 @default.
- W4295905819 cites W3212724181 @default.
- W4295905819 cites W3214175544 @default.
- W4295905819 cites W4205533766 @default.
- W4295905819 cites W4206470999 @default.
- W4295905819 cites W4226360696 @default.
- W4295905819 cites W4232349440 @default.
- W4295905819 cites W4282053318 @default.
- W4295905819 cites W4286295747 @default.
- W4295905819 doi "https://doi.org/10.1080/14737140.2022.2125382" @default.
- W4295905819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36106496" @default.
- W4295905819 hasPublicationYear "2022" @default.
- W4295905819 type Work @default.
- W4295905819 citedByCount "0" @default.
- W4295905819 crossrefType "journal-article" @default.
- W4295905819 hasAuthorship W4295905819A5017176613 @default.
- W4295905819 hasAuthorship W4295905819A5075324403 @default.
- W4295905819 hasBestOaLocation W42959058192 @default.
- W4295905819 hasConcept C121608353 @default.
- W4295905819 hasConcept C126322002 @default.
- W4295905819 hasConcept C143998085 @default.
- W4295905819 hasConcept C2777381376 @default.
- W4295905819 hasConcept C2777701055 @default.
- W4295905819 hasConcept C2780030458 @default.
- W4295905819 hasConcept C2780057760 @default.
- W4295905819 hasConcept C2908647359 @default.
- W4295905819 hasConcept C535046627 @default.
- W4295905819 hasConcept C71924100 @default.
- W4295905819 hasConcept C99454951 @default.
- W4295905819 hasConceptScore W4295905819C121608353 @default.
- W4295905819 hasConceptScore W4295905819C126322002 @default.
- W4295905819 hasConceptScore W4295905819C143998085 @default.
- W4295905819 hasConceptScore W4295905819C2777381376 @default.
- W4295905819 hasConceptScore W4295905819C2777701055 @default.
- W4295905819 hasConceptScore W4295905819C2780030458 @default.
- W4295905819 hasConceptScore W4295905819C2780057760 @default.
- W4295905819 hasConceptScore W4295905819C2908647359 @default.
- W4295905819 hasConceptScore W4295905819C535046627 @default.
- W4295905819 hasConceptScore W4295905819C71924100 @default.
- W4295905819 hasConceptScore W4295905819C99454951 @default.