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- W4295906312 endingPage "111348" @default.
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- W4295906312 abstract "Despite therapeutic interventions for glioblastoma (GBM), cancer stem cells (CSCs) drive recurrence. The precise mechanisms underlying CSC resistance, namely inhibition of cell death, are unclear. We built on previous observations that the high cell surface expression of junctional adhesion molecule-A drives CSC maintenance and identified downstream signaling networks, including the cysteine protease inhibitor SerpinB3. Using genetic depletion approaches, we found that SerpinB3 is necessary for CSC maintenance, survival, and tumor growth, as well as CSC pathway activation. Knockdown of SerpinB3 also increased apoptosis and susceptibility to radiation therapy. SerpinB3 was essential to buffer cathepsin L-mediated cell death, which was enhanced with radiation. Finally, we found that SerpinB3 knockdown increased the efficacy of radiation in pre-clinical models. Taken together, our findings identify a GBM CSC-specific survival mechanism involving a cysteine protease inhibitor, SerpinB3, and provide a potential target to improve the efficacy of GBM therapies against therapeutically resistant CSCs." @default.
- W4295906312 created "2022-09-16" @default.
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- W4295906312 date "2022-09-01" @default.
- W4295906312 modified "2023-10-02" @default.
- W4295906312 title "SerpinB3 drives cancer stem cell survival in glioblastoma" @default.
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- W4295906312 cites W1967913719 @default.
- W4295906312 cites W1988986134 @default.
- W4295906312 cites W1989958716 @default.
- W4295906312 cites W1993094147 @default.
- W4295906312 cites W1996109465 @default.
- W4295906312 cites W1997005119 @default.
- W4295906312 cites W2001544973 @default.
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- W4295906312 cites W2012034410 @default.
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- W4295906312 cites W2019727978 @default.
- W4295906312 cites W2022520367 @default.
- W4295906312 cites W2024711136 @default.
- W4295906312 cites W2027303624 @default.
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- W4295906312 cites W2056182070 @default.
- W4295906312 cites W2060551076 @default.
- W4295906312 cites W2069642304 @default.
- W4295906312 cites W2074146726 @default.
- W4295906312 cites W2096287682 @default.
- W4295906312 cites W2112289496 @default.
- W4295906312 cites W2118587530 @default.
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- W4295906312 cites W2120504201 @default.
- W4295906312 cites W2123434257 @default.
- W4295906312 cites W2135925682 @default.
- W4295906312 cites W2146001608 @default.
- W4295906312 cites W2146601467 @default.
- W4295906312 cites W2151385495 @default.
- W4295906312 cites W2165918134 @default.
- W4295906312 cites W2167010018 @default.
- W4295906312 cites W2167279371 @default.
- W4295906312 cites W2167414381 @default.
- W4295906312 cites W2167844024 @default.
- W4295906312 cites W2168628406 @default.
- W4295906312 cites W2237475663 @default.
- W4295906312 cites W2255291773 @default.
- W4295906312 cites W2339549469 @default.
- W4295906312 cites W2509858589 @default.
- W4295906312 cites W2518780897 @default.
- W4295906312 cites W2575704225 @default.
- W4295906312 cites W2739511077 @default.
- W4295906312 cites W2741508285 @default.
- W4295906312 cites W2778283729 @default.
- W4295906312 cites W2888292224 @default.
- W4295906312 cites W2896382534 @default.
- W4295906312 cites W2901650187 @default.
- W4295906312 cites W2914214085 @default.
- W4295906312 cites W2948278325 @default.
- W4295906312 cites W2952121859 @default.
- W4295906312 cites W2982258088 @default.
- W4295906312 cites W2995682532 @default.
- W4295906312 cites W3005258006 @default.
- W4295906312 cites W3041901315 @default.
- W4295906312 cites W3049205015 @default.
- W4295906312 cites W3096532977 @default.
- W4295906312 cites W3098385947 @default.
- W4295906312 cites W3108698225 @default.
- W4295906312 cites W3124733297 @default.
- W4295906312 cites W3134326888 @default.
- W4295906312 cites W3196974748 @default.
- W4295906312 cites W3200316579 @default.
- W4295906312 cites W4205339800 @default.
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- W4295906312 doi "https://doi.org/10.1016/j.celrep.2022.111348" @default.
- W4295906312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36103817" @default.