FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295907574> ?p ?o ?g. }

• W4295907574 endingPage "14120" @default.
• W4295907574 startingPage "14111" @default.
• W4295907574 abstract "Fast protein translocations often lead to bandwidth-limited amplitude-attenuated event signatures. In this study, we developed a protein- and electrolyte chemistry-centric pathway to construct a readily executable decision tree for the detection of non-attenuated protein translocations using conventional electronics. Each optimization encompasses increasing capture rate (CR), signal-to-noise ratio (SNR), and minimizing irreversible analyte clogging to collect >104 events/pipette spanning a host of electric fields. This was demonstrated using 11 proteins ranging from ∼12 kDa to ∼720 kDa. Moreover, both symmetric and asymmetric electrolyte conditions (cis and trans chamber electrolyte concentration ratios <> 1) were explored. As a result, asymmetric electrolyte conditions were favorable on the extreme ends of the size spectrum (i.e., larger, and smaller proteins) and while the remainder of proteins were best sensed under symmetric electrolyte conditions. Under these optimal conditions, only ≲10% of events were attenuated at 500 mV (≲ 5% for most proteins at 500 mV with only ≲1-5% of the population faster than ∼7 μs, which is the theoretical attenuation threshold for 100 kHz bandwidth). Finally, applied voltage (Vapp), peak current drop (ΔIp), electrolyte conductivity (K), and open-pore conductance (G0) were used to generate a linear relationship to evaluate the molecular weight of the protein (Mw) using plots of (dΔIp)/(dVapp) vs Mw/(G0/K)." @default.
• W4295907574 created "2022-09-16" @default.
• W4295907574 creator A5028558792 @default.
• W4295907574 creator A5073547471 @default.
• W4295907574 date "2022-09-15" @default.
• W4295907574 modified "2023-10-16" @default.
• W4295907574 title "Enhanced Signal to Noise Ratio Enables High Bandwidth Nanopore Recordings and Molecular Weight Profiling of Proteins" @default.
• W4295907574 cites W1964752817 @default.
• W4295907574 cites W2001654715 @default.
• W4295907574 cites W2004863845 @default.
• W4295907574 cites W2015359849 @default.
• W4295907574 cites W2018822918 @default.
• W4295907574 cites W2038391383 @default.
• W4295907574 cites W2057842249 @default.
• W4295907574 cites W2059648430 @default.
• W4295907574 cites W2073463817 @default.
• W4295907574 cites W2094153893 @default.
• W4295907574 cites W2097065797 @default.
• W4295907574 cites W2099674667 @default.
• W4295907574 cites W2133372935 @default.
• W4295907574 cites W2148217165 @default.
• W4295907574 cites W2178096376 @default.
• W4295907574 cites W2266610436 @default.
• W4295907574 cites W2316903776 @default.
• W4295907574 cites W2512389053 @default.
• W4295907574 cites W2569423563 @default.
• W4295907574 cites W2794127121 @default.
• W4295907574 cites W2796670593 @default.
• W4295907574 cites W2886476494 @default.
• W4295907574 cites W2906098769 @default.
• W4295907574 cites W2922233777 @default.
• W4295907574 cites W2944651360 @default.
• W4295907574 cites W2962819954 @default.
• W4295907574 cites W3016896211 @default.
• W4295907574 cites W3107287854 @default.
• W4295907574 cites W3133629087 @default.
• W4295907574 cites W3180268946 @default.
• W4295907574 cites W3194068388 @default.
• W4295907574 cites W3210111871 @default.
• W4295907574 cites W4206748511 @default.
• W4295907574 cites W4211135069 @default.
• W4295907574 doi "https://doi.org/10.1021/acsnano.2c04046" @default.
• W4295907574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36107037" @default.
• W4295907574 hasPublicationYear "2022" @default.
• W4295907574 type Work @default.
• W4295907574 citedByCount "5" @default.
• W4295907574 countsByYear W42959075742023 @default.
• W4295907574 crossrefType "journal-article" @default.
• W4295907574 hasAuthorship W4295907574A5028558792 @default.
• W4295907574 hasAuthorship W4295907574A5073547471 @default.
• W4295907574 hasConcept C10390740 @default.
• W4295907574 hasConcept C104292427 @default.
• W4295907574 hasConcept C104317684 @default.
• W4295907574 hasConcept C113196181 @default.
• W4295907574 hasConcept C144024400 @default.
• W4295907574 hasConcept C147789679 @default.
• W4295907574 hasConcept C149923435 @default.
• W4295907574 hasConcept C17525397 @default.
• W4295907574 hasConcept C185592680 @default.
• W4295907574 hasConcept C192562407 @default.
• W4295907574 hasConcept C2778481663 @default.
• W4295907574 hasConcept C2908647359 @default.
• W4295907574 hasConcept C43617362 @default.
• W4295907574 hasConcept C55493867 @default.
• W4295907574 hasConcept C68801617 @default.
• W4295907574 hasConceptScore W4295907574C10390740 @default.
• W4295907574 hasConceptScore W4295907574C104292427 @default.
• W4295907574 hasConceptScore W4295907574C104317684 @default.
• W4295907574 hasConceptScore W4295907574C113196181 @default.
• W4295907574 hasConceptScore W4295907574C144024400 @default.
• W4295907574 hasConceptScore W4295907574C147789679 @default.
• W4295907574 hasConceptScore W4295907574C149923435 @default.
• W4295907574 hasConceptScore W4295907574C17525397 @default.
• W4295907574 hasConceptScore W4295907574C185592680 @default.
• W4295907574 hasConceptScore W4295907574C192562407 @default.
• W4295907574 hasConceptScore W4295907574C2778481663 @default.
• W4295907574 hasConceptScore W4295907574C2908647359 @default.
• W4295907574 hasConceptScore W4295907574C43617362 @default.
• W4295907574 hasConceptScore W4295907574C55493867 @default.
• W4295907574 hasConceptScore W4295907574C68801617 @default.
• W4295907574 hasFunder F4320320338 @default.
• W4295907574 hasIssue "9" @default.
• W4295907574 hasLocation W42959075741 @default.
• W4295907574 hasLocation W42959075742 @default.
• W4295907574 hasOpenAccess W4295907574 @default.
• W4295907574 hasPrimaryLocation W42959075741 @default.
• W4295907574 hasRelatedWork W1944150046 @default.
• W4295907574 hasRelatedWork W1975062759 @default.
• W4295907574 hasRelatedWork W1981201449 @default.
• W4295907574 hasRelatedWork W2032726277 @default.
• W4295907574 hasRelatedWork W2061679850 @default.
• W4295907574 hasRelatedWork W2071548110 @default.
• W4295907574 hasRelatedWork W2082761856 @default.
• W4295907574 hasRelatedWork W2285030699 @default.
• W4295907574 hasRelatedWork W2951342429 @default.
• W4295907574 hasRelatedWork W2972474321 @default.
• W4295907574 hasVolume "16" @default.
• W4295907574 isParatext "false" @default.

• next