FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295908643> ?p ?o ?g. }

• W4295908643 abstract "The humoral and cellular response to SARS-CoV-2 mRNA full vaccination and booster dose as well as the impact of the spike variants, including Omicron, are still unclear in patients with multiple myeloma (MM) and those with pre-malignant monoclonal gammopathies. In this study, involving 40 patients, we found that MM patients with relapsed-refractory disease (MMR) had reduced spike-specific antibody levels and neutralizing titers after SARS-CoV-2 vaccination. The five analyzed variants, remarkably Omicron, had a significant negative impact on the neutralizing ability of the vaccine-induced antibodies in all patients with MM and smoldering MM. Moreover, lower spike-specific IL-2-producing CD4+ T cells and reduced cytotoxic spike-specific IFN-γ and TNF-α-producing CD8+ T cells were found in MM patients as compared to patients with monoclonal gammopathy of undetermined significance. We found that a heterologous booster immunization improved SARS-CoV-2 spike humoral and cellular responses in newly diagnosed MM (MMD) patients and in most, but not all, MMR patients. After the booster dose, a significant increase of the neutralizing antibody titers against almost all the analyzed variants was achieved in MMD. However, in MMR patients, Omicron retained a negative impact on neutralizing ability, suggesting further approaches to potentiating the effectiveness of SARS-CoV-2 vaccination in these patients." @default.
• W4295908643 created "2022-09-16" @default.
• W4295908643 creator A5010179985 @default.
• W4295908643 creator A5023389387 @default.
• W4295908643 creator A5025509285 @default.
• W4295908643 creator A5035496022 @default.
• W4295908643 creator A5037948411 @default.
• W4295908643 creator A5043503519 @default.
• W4295908643 creator A5044141306 @default.
• W4295908643 creator A5046458747 @default.
• W4295908643 creator A5048738889 @default.
• W4295908643 creator A5053482670 @default.
• W4295908643 creator A5083314734 @default.
• W4295908643 creator A5086250638 @default.
• W4295908643 creator A5086719079 @default.
• W4295908643 creator A5089903366 @default.
• W4295908643 creator A5091831306 @default.
• W4295908643 date "2022-09-06" @default.
• W4295908643 modified "2023-10-18" @default.
• W4295908643 title "Immune response to SARS-CoV-2 mRNA vaccination and booster dose in patients with multiple myeloma and monoclonal gammopathies: impact of Omicron variant on the humoral response" @default.
• W4295908643 cites W1580057258 @default.
• W4295908643 cites W2005539485 @default.
• W4295908643 cites W2100545964 @default.
• W4295908643 cites W2148323116 @default.
• W4295908643 cites W3025320502 @default.
• W4295908643 cites W3032944534 @default.
• W4295908643 cites W3048775784 @default.
• W4295908643 cites W3069281433 @default.
• W4295908643 cites W3084879098 @default.
• W4295908643 cites W3093376706 @default.
• W4295908643 cites W3109562426 @default.
• W4295908643 cites W3119179495 @default.
• W4295908643 cites W3119858919 @default.
• W4295908643 cites W3131995220 @default.
• W4295908643 cites W3133980772 @default.
• W4295908643 cites W3134446480 @default.
• W4295908643 cites W3137469790 @default.
• W4295908643 cites W3137901781 @default.
• W4295908643 cites W3153656426 @default.
• W4295908643 cites W3162395942 @default.
• W4295908643 cites W3162400064 @default.
• W4295908643 cites W3168349393 @default.
• W4295908643 cites W3172858351 @default.
• W4295908643 cites W3173150656 @default.
• W4295908643 cites W3183558279 @default.
• W4295908643 cites W3187511802 @default.
• W4295908643 cites W3196516725 @default.
• W4295908643 cites W3199849883 @default.
• W4295908643 cites W3205364181 @default.
• W4295908643 cites W3206038157 @default.
• W4295908643 cites W3214087093 @default.
• W4295908643 cites W4200006229 @default.
• W4295908643 cites W4200054119 @default.
• W4295908643 cites W4200090310 @default.
• W4295908643 cites W4200391585 @default.
• W4295908643 cites W4200574310 @default.
• W4295908643 cites W4205687361 @default.
• W4295908643 cites W4207047906 @default.
• W4295908643 cites W4210272290 @default.
• W4295908643 cites W4210450230 @default.
• W4295908643 cites W4210489202 @default.
• W4295908643 cites W4210585357 @default.
• W4295908643 cites W4210632919 @default.
• W4295908643 cites W4210664421 @default.
• W4295908643 cites W4220673385 @default.
• W4295908643 cites W4220704253 @default.
• W4295908643 cites W4221116249 @default.
• W4295908643 cites W4223508610 @default.
• W4295908643 cites W4225625436 @default.
• W4295908643 doi "https://doi.org/10.1080/2162402x.2022.2120275" @default.
• W4295908643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36105747" @default.
• W4295908643 hasPublicationYear "2022" @default.
• W4295908643 type Work @default.
• W4295908643 citedByCount "10" @default.
• W4295908643 countsByYear W42959086432022 @default.
• W4295908643 countsByYear W42959086432023 @default.
• W4295908643 crossrefType "journal-article" @default.
• W4295908643 hasAuthorship W4295908643A5010179985 @default.
• W4295908643 hasAuthorship W4295908643A5023389387 @default.
• W4295908643 hasAuthorship W4295908643A5025509285 @default.
• W4295908643 hasAuthorship W4295908643A5035496022 @default.
• W4295908643 hasAuthorship W4295908643A5037948411 @default.
• W4295908643 hasAuthorship W4295908643A5043503519 @default.
• W4295908643 hasAuthorship W4295908643A5044141306 @default.
• W4295908643 hasAuthorship W4295908643A5046458747 @default.
• W4295908643 hasAuthorship W4295908643A5048738889 @default.
• W4295908643 hasAuthorship W4295908643A5053482670 @default.
• W4295908643 hasAuthorship W4295908643A5083314734 @default.
• W4295908643 hasAuthorship W4295908643A5086250638 @default.
• W4295908643 hasAuthorship W4295908643A5086719079 @default.
• W4295908643 hasAuthorship W4295908643A5089903366 @default.
• W4295908643 hasAuthorship W4295908643A5091831306 @default.
• W4295908643 hasBestOaLocation W42959086431 @default.
• W4295908643 hasConcept C154317977 @default.
• W4295908643 hasConcept C159047783 @default.
• W4295908643 hasConcept C159654299 @default.
• W4295908643 hasConcept C163864487 @default.
• W4295908643 hasConcept C202751555 @default.
• W4295908643 hasConcept C203014093 @default.
• W4295908643 hasConcept C22070199 @default.

• next