FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295919983> ?p ?o ?g. }

• W4295919983 endingPage "3716" @default.
• W4295919983 startingPage "3709" @default.
• W4295919983 abstract "The present study is aimed at the design and development of aceclofenac co-crystals. Co-crystallization is one of the important techniques which helps to enhance the aqueous solubility of drugs by modifying the crystal structure using incorporation of the co-former into the formulation.. In the present study, supramolecular synthon approach and computational grid scan methods were used for the co-former selection. The different co-formers such as oxalic acid (OA), succinic acid (SA), maleic acid (MA), and benzoic acid (BA) were used. Aceclofenac (ACF) co-crystals were prepared by solvent evaporation and dry grinding method. Based on the computational results and experimental saturation solubility studies, maleic acid was considered as the suitable co-former for the preparation. The solid-state characterization showed partial conversion of ACF crystallinity to the amorphization as evident from the decrease in peak intensity and the number of peaks. The co-crystals showed increased aqueous solubility of ACF and higher drug release in basic pH. All the characterization parameters proved the co-crystal formation and the in vitro release studies showed that the solubility enhancement of the ACF by preparing ACF-MA co-crystals. Thus, it can be concluded that co-crystallization is one of the novel method for improving the bioavailability of aceclofenac." @default.
• W4295919983 created "2022-09-16" @default.
• W4295919983 creator A5016805509 @default.
• W4295919983 creator A5018650650 @default.
• W4295919983 creator A5025151210 @default.
• W4295919983 creator A5032926221 @default.
• W4295919983 creator A5037186737 @default.
• W4295919983 creator A5088742364 @default.
• W4295919983 date "2022-08-30" @default.
• W4295919983 modified "2023-09-29" @default.
• W4295919983 title "Computational and Experimental Insights in Design and Development of Aceclofenac Co-Crystals" @default.
• W4295919983 cites W1122950467 @default.
• W4295919983 cites W1992255438 @default.
• W4295919983 cites W2000536899 @default.
• W4295919983 cites W2007237444 @default.
• W4295919983 cites W2018970582 @default.
• W4295919983 cites W2025563275 @default.
• W4295919983 cites W2045091825 @default.
• W4295919983 cites W2056794714 @default.
• W4295919983 cites W2062596549 @default.
• W4295919983 cites W2065348393 @default.
• W4295919983 cites W2072185489 @default.
• W4295919983 cites W2081497149 @default.
• W4295919983 cites W2083086205 @default.
• W4295919983 cites W2127732020 @default.
• W4295919983 cites W2151823004 @default.
• W4295919983 cites W2165062576 @default.
• W4295919983 cites W2293110263 @default.
• W4295919983 cites W2325581147 @default.
• W4295919983 cites W2734618898 @default.
• W4295919983 cites W2749113740 @default.
• W4295919983 cites W2770454322 @default.
• W4295919983 cites W2774535559 @default.
• W4295919983 cites W2780471111 @default.
• W4295919983 cites W2804953810 @default.
• W4295919983 cites W2886419664 @default.
• W4295919983 cites W2900954027 @default.
• W4295919983 cites W2964490555 @default.
• W4295919983 cites W3158198504 @default.
• W4295919983 cites W4254163371 @default.
• W4295919983 doi "https://doi.org/10.52711/0974-360x.2022.00622" @default.
• W4295919983 hasPublicationYear "2022" @default.
• W4295919983 type Work @default.
• W4295919983 citedByCount "1" @default.
• W4295919983 countsByYear W42959199832023 @default.
• W4295919983 crossrefType "journal-article" @default.
• W4295919983 hasAuthorship W4295919983A5016805509 @default.
• W4295919983 hasAuthorship W4295919983A5018650650 @default.
• W4295919983 hasAuthorship W4295919983A5025151210 @default.
• W4295919983 hasAuthorship W4295919983A5032926221 @default.
• W4295919983 hasAuthorship W4295919983A5037186737 @default.
• W4295919983 hasAuthorship W4295919983A5088742364 @default.
• W4295919983 hasConcept C100687433 @default.
• W4295919983 hasConcept C112887158 @default.
• W4295919983 hasConcept C127413603 @default.
• W4295919983 hasConcept C13965031 @default.
• W4295919983 hasConcept C155574463 @default.
• W4295919983 hasConcept C15920480 @default.
• W4295919983 hasConcept C159985019 @default.
• W4295919983 hasConcept C178790620 @default.
• W4295919983 hasConcept C184651966 @default.
• W4295919983 hasConcept C185592680 @default.
• W4295919983 hasConcept C192562407 @default.
• W4295919983 hasConcept C203036418 @default.
• W4295919983 hasConcept C2780976021 @default.
• W4295919983 hasConcept C2781041046 @default.
• W4295919983 hasConcept C2781206178 @default.
• W4295919983 hasConcept C32909587 @default.
• W4295919983 hasConcept C42360764 @default.
• W4295919983 hasConcept C43617362 @default.
• W4295919983 hasConcept C46275449 @default.
• W4295919983 hasConcept C521977710 @default.
• W4295919983 hasConceptScore W4295919983C100687433 @default.
• W4295919983 hasConceptScore W4295919983C112887158 @default.
• W4295919983 hasConceptScore W4295919983C127413603 @default.
• W4295919983 hasConceptScore W4295919983C13965031 @default.
• W4295919983 hasConceptScore W4295919983C155574463 @default.
• W4295919983 hasConceptScore W4295919983C15920480 @default.
• W4295919983 hasConceptScore W4295919983C159985019 @default.
• W4295919983 hasConceptScore W4295919983C178790620 @default.
• W4295919983 hasConceptScore W4295919983C184651966 @default.
• W4295919983 hasConceptScore W4295919983C185592680 @default.
• W4295919983 hasConceptScore W4295919983C192562407 @default.
• W4295919983 hasConceptScore W4295919983C203036418 @default.
• W4295919983 hasConceptScore W4295919983C2780976021 @default.
• W4295919983 hasConceptScore W4295919983C2781041046 @default.
• W4295919983 hasConceptScore W4295919983C2781206178 @default.
• W4295919983 hasConceptScore W4295919983C32909587 @default.
• W4295919983 hasConceptScore W4295919983C42360764 @default.
• W4295919983 hasConceptScore W4295919983C43617362 @default.
• W4295919983 hasConceptScore W4295919983C46275449 @default.
• W4295919983 hasConceptScore W4295919983C521977710 @default.
• W4295919983 hasLocation W42959199831 @default.
• W4295919983 hasOpenAccess W4295919983 @default.
• W4295919983 hasPrimaryLocation W42959199831 @default.
• W4295919983 hasRelatedWork W1981902352 @default.
• W4295919983 hasRelatedWork W2324945584 @default.
• W4295919983 hasRelatedWork W2333880777 @default.

• next