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- W4295932668 abstract "Abstract We assessed the relationship of gene copy number variation (CNV) in mental health/neurodevelopmental traits and diagnoses, physical health, and cognitive biomarkers in a community sample of 7,100 unrelated European, and East Asian children and youth (Spit for Science). Diagnoses of mental health disorders were found in 17.5% of participants and 27.6% scored in the highest 10% on either or both ADHD and OCD trait measures. Clinically relevant CNVs were present in 3.9% of participants and were associated with elevated scores on a continuous measure of ADHD ( p =5.0×10 −3 ), on a cognitive biomarker of mental health (response inhibition ( p =1.0×10 −2 )), and on prevalence of mental disorders ( p =1.9×10 −6 , odds ratio: 3.09). With a rise of mental illness, our data establishes a baseline for delineating genetic contributors in paediatric-onset conditions. One Sentence Summary Copy number variation predicts neurodevelopmental and mental health phenotypes in the general population." @default.
- W4295932668 created "2022-09-16" @default.
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- W4295932668 date "2022-09-15" @default.
- W4295932668 modified "2023-10-02" @default.
- W4295932668 title "Gene copy number variation in pediatric mental illness in a general population" @default.
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- W4295932668 doi "https://doi.org/10.1101/2022.09.12.22279764" @default.
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