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• W4295945118 abstract "The aim of this study was to develop a preoperative risk scoring model for distinguishing lymphoepithelioma-like gastric carcinoma (LELGC) from non-LELGC based on contrast-enhanced computed tomography (CT) images.Clinicopathological features and CT findings of patients with LELGC and non-LELGC in our hospital from January 2016 to July 2022 were retrospectively analyzed and compared. A preoperative risk stratification model and a risk scoring system were developed using logistic regression.Twenty patients with LELGC and 40 patients with non-LELGC were included in the training cohort. Significant differences were observed in Epstein-Barr virus (EBV) infection and vascular invasion between the two groups (p < 0.05). Significant differences were observed in the distribution of location, enhancement pattern, homogeneous enhancement, CT-defined lymph node status, and attenuations in the non-contrast, arterial, and venous phases (all p < 0.05). Enhancement pattern, CT-defined lymph node status, and attenuation in venous phase were independent predictors of LELGC. The optimal cutoff score of distinguishing LELGC from non-LELGC was 3.5. The area under the receiver operating characteristic curve, sensitivity, specificity, and accuracy of risk identification model in the training cohort were 0.904, 87.5%, 80.0%, and 85.0%, respectively. The area under the receiver operating characteristic curve, sensitivity, specificity, and accuracy of risk identification model in the validation cohort were 0.705 (95% CI 0.434-0.957), 75.0%, 63.6%, and 66.7%, respectively.A preoperative risk identification model based on CT imaging data could be helpful for distinguishing LELGC from non-LELGC." @default.
• W4295945118 created "2022-09-16" @default.
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• W4295945118 date "2022-09-15" @default.
• W4295945118 modified "2023-10-18" @default.
• W4295945118 title "A computed tomography-based preoperative risk scoring system to distinguish lymphoepithelioma-like gastric carcinoma from non-lymphoepithelioma-like gastric carcinoma" @default.
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• W4295945118 doi "https://doi.org/10.3389/fonc.2022.872814" @default.
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