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- W4295969658 abstract "Abstract Background It is unclear which patients with recurrence after a second hepatectomy will benefit from a third hepatectomy. Methods Patients who underwent hepatectomy for colorectal liver metastasis (CRLM) between April 2005 and July 2021 were included. Factors affecting recurrence after each hepatectomy were analyzed. Results Sixty‐four of the 167 patients who had recurrence after the first hepatectomy underwent a second hepatectomy. Then, 46 patients had recurrence and 18 patients did not have recurrence after the second hepatectomy. Sixteen patients who underwent a third hepatectomy had better overall survival (OS) than those who did not (52 vs. 31 months, p = 0.043). However, the multivariate analysis demonstrated that only tumor size (>5 cm) during the second hepatectomy ( p = 0.022) and carbohydrate antigen 19‐9 (CA 19‐9) level (>50 U/ml) ( p = 0.041) at recurrence after the second hepatectomy were poor prognostic factors for OS. Conclusion While a third hepatectomy can be performed if it is technically and oncologically appropriate, tumor size >5 cm and CA 19‐9 >50 U/ml should be considered in terms of long‐term outcomes before proceeding to surgery." @default.
- W4295969658 created "2022-09-16" @default.
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- W4295969658 date "2022-08-10" @default.
- W4295969658 modified "2023-10-12" @default.
- W4295969658 title "Reconsideration of indications for third hepatectomy for colorectal liver metastases" @default.
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- W4295969658 doi "https://doi.org/10.1002/jso.27050" @default.
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