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- W4295977979 abstract "Abstract Metazoans establish mutually beneficial interactions with their resident microorganisms. However, our understanding of the microbial cues contributing to host physiology remains elusive. Previously, we identified a bacterial machinery encoded by the dlt operon involved in Drosophila melanogaster ’s juvenile growth promotion by Lactiplantibacillus plantarum . Here, using crystallography combined with biochemical and cellular approaches, we investigate the physiological role of an uncharacterized protein (DltE) encoded by this operon. We show that LTAs but not WTAs are D-alanylated in Lactiplantibacillus plantarum NC8 cell envelope and demonstrate that DltE is a D-Ala carboxyesterase removing D-Ala from LTA. Using the mutualistic association of L. plantarum NC8 and Drosophila melanogaster as a symbiosis model, we establish that D-Ala-LTAs are direct symbiotic cues supporting intestinal peptidase expression and juvenile growth in Drosophila. Our results pave the way to probing the contribution of D-Ala-LTA to host physiology in other symbiotic models." @default.
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- W4295977979 date "2022-09-14" @default.
- W4295977979 modified "2023-10-17" @default.
- W4295977979 title "Structure-Function analysis of <i>Lactiplantibacillus plantarum</i> DltE reveals D-alanylated lipoteichoic acids as direct symbiotic cues supporting <i>Drosophila</i> juvenile growth" @default.
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- W4295977979 doi "https://doi.org/10.1101/2022.09.14.507969" @default.
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