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- W4295988909 abstract "The movement of macromolecules and nutrients in the brain is essential for brain health. Several neurological diseases are associated with the accumulation of amyloid beta or other waste products within the brain parenchyma. Alzheimer’s disease, for example, is associated with elevated levels of amyloid beta peptides and tau proteins. Similarly, the brain tissue of patients with Parkinson’s disease has a significant presence of Lewy bodies, another type of aggregated protein. The pathophysiology of these diseases includes elevated levels of cytokines and inflammasomes. Some have suggested that the increased production of cerebrospinal fluid during sleep might pass through the brain parenchyma and thereby clear such amyloid beta and misfolded proteins through the glymphatic pathway. While the brain is without common lymph vessels, subarachnoid lymphatic vessels have been (re)discovered and this strongly supports exchange of cerebral spinal fluid between the lateral ventricles and the lymph system to increase flow of the interstitial fluid through the brain parenchyma. The brain also possesses unusually selective capillaries that are supported by astrocyte foot processes. These unusual features lead to mass transport in the brain being an area of active research. This chapter offers a review of the mechanics of mass transport in the brain parenchyma with specific consideration of the amyloid beta and related species." @default.
- W4295988909 created "2022-09-16" @default.
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- W4295988909 date "2022-01-01" @default.
- W4295988909 modified "2023-09-23" @default.
- W4295988909 title "Modeling transport of soluble proteins and metabolites in the brain" @default.
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- W4295988909 doi "https://doi.org/10.1016/b978-0-323-85740-6.00004-2" @default.
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