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- W4295997943 abstract "Biological systems—in all their diverse forms, ranging from macromolecules to multicellular organisms—are highly complex and dynamic. Recent advances in genome editing, coupled with substantial reductions in DNA sequencing and synthesis costs, have opened new opportunities for harnessing this potential of DNA as an information storage system for biological applications. This chapter reviews the development and existing applications of CRISPR-Cas systems for DNA writing and discuss features and current limitations of these technologies for recording biological information in living cells. Molecular recording can be classified into digital and analog based on the encoding regime. CRISPR spacer acquisition evolved in bacteria and archaea as a natural mechanism to capture molecular records of genetic encounters and horizontal gene transfer events in the form of spacers stored within CRISPR arrays." @default.
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- W4295997943 date "2022-08-30" @default.
- W4295997943 modified "2023-09-27" @default.
- W4295997943 title "Recording Biological Information with <scp>CRISPR</scp> ‐ <scp>Cas</scp> Systems" @default.
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- W4295997943 doi "https://doi.org/10.1002/9781683673798.ch16" @default.
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