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- W4296005320 abstract "Due to the body's systemic distribution of photothermal agents (PTAs), and to the imprecise exposure of lasers, photothermal therapy (PTT) is challenging to use in treating tumor sites selectively. Striving for PTT with high selectivity and precise treatment is nevertheless important, in order to raise the survival rate of cancer patients and lower the likelihood of adverse effects on other body sections. Here, we studied cold atmospheric plasma (CAP) as a supplementary procedure to enhance selectivity of PTT for cancer, using the classical photothermic agent's gold nanostars (AuNSs). In in vitro experiments, CAP decreases the effective power of PTT: the combination of PTT with CAP at lower power has similar cytotoxicity to that using higher power irradiation alone. In in vivo experiments, combination therapy can achieve rapid tumor suppression in the early stages of treatment and reduce side effects to surrounding normal tissues, compared to applying PTT alone. This research provides a strategy for the use of selective PTT for cancer, and promotes the clinical transformation of CAP." @default.
- W4296005320 created "2022-09-17" @default.
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- W4296005320 date "2022-09-13" @default.
- W4296005320 modified "2023-10-12" @default.
- W4296005320 title "Cold Atmospheric Plasma Activates Selective Photothermal Therapy of Cancer" @default.
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- W4296005320 doi "https://doi.org/10.3390/molecules27185941" @default.
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