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- W4296011313 abstract "Squamous cell anal carcinoma (SCAC) is an uncommon neoplasia often cured by surgery and/or chemo-radiation therapy at the localized stage. Although the first-line of treatment for metastatic SCAC (mSCAC) is better codified with two validated treatment regimens, carboplatin-paclitaxel and modified DCF (docetaxel-cisplatin-5FU), there is no consensus regarding subsequent lines. EGFR (epidermal growth factor receptor) inhibitors have proven efficacy in HPV+ tumors such as head and neck SCC. Up to 80% of SCAC are related to HPV infection and 90% of SCAC overexpress EGFR, supporting the use of anti-EGFR in the treatment of mSCAC." @default.
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- W4296011313 date "2022-09-01" @default.
- W4296011313 modified "2023-09-23" @default.
- W4296011313 title "434P Cetuximab in combination with 5 FU plus irinotecan based chemotherapy in metastatic squamous cell anal carcinoma: A single center experience" @default.
- W4296011313 doi "https://doi.org/10.1016/j.annonc.2022.07.572" @default.
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