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- W4296016614 endingPage "1908" @default.
- W4296016614 startingPage "1908" @default.
- W4296016614 abstract "Various immunotherapeutic agents that can elicit antitumor immune responses have recently been developed with the potential for improved efficacy in treating cancer. However, insufficient delivery efficiency at the tumor site, along with severe side effects after systemic administration of these anticancer agents, have hindered their therapeutic application in cancer immunotherapy. Hydrogels that can be directly injected into tumor sites have been developed to help modulate or elicit antitumor responses. Based on the biocompatibility, degradability, and controllable mechanochemical properties of these injectable hydrogels, various types of immunotherapeutic agents, such as hydrophobic anticancer drugs, cytokines, antigens, and adjuvants, have been easily and effectively encapsulated, resulting in the successful elicitation of antitumor immune responses and the retention of long-term immunotherapeutic efficacy following administration. This review summarizes recent advances in combination immunotherapy involving injectable hydrogel-based chemoimmunotherapy, photoimmunotherapy, and radioimmunotherapy. Finally, we briefly discuss the current limitations and future perspectives on injectable hydrogels for the effective combination immunotherapy of tumors." @default.
- W4296016614 created "2022-09-17" @default.
- W4296016614 creator A5021598645 @default.
- W4296016614 creator A5055447223 @default.
- W4296016614 creator A5065286478 @default.
- W4296016614 creator A5070565501 @default.
- W4296016614 creator A5082857415 @default.
- W4296016614 date "2022-09-08" @default.
- W4296016614 modified "2023-10-16" @default.
- W4296016614 title "Injectable Hydrogel-Based Combination Cancer Immunotherapy for Overcoming Localized Therapeutic Efficacy" @default.
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