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• W4296023635 abstract "Abstract As an effective graphical representation method for 1D sequence (e.g., text), Chaos Game Representation (CGR) has been frequently combined with deep learning (DL) for biological analysis. In this study, we developed a unique approach to encode peptide/protein sequences into CGR images for classification. To this end, we designed a novel energy function and enhanced the encoder quality by constructing a Supervised Autoencoders (SAE) neural network. CGR was used to represent the amino acid sequences and such representation was optimized based on the latent variables with SAE. To assess the effectiveness of our new representation scheme, we further employed convolutional neural network (CNN) to build models to study hemolytic/non-hemolytic peptides and the susceptibility/resistance of HIV protease mutants to approved drugs. Comparisons were also conducted with other published methods, and our approach demonstrated superior performance. Supplementary information available online" @default.
• W4296023635 created "2022-09-17" @default.
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• W4296023635 date "2022-09-13" @default.
• W4296023635 modified "2023-10-16" @default.
• W4296023635 title "Sequence-based Optimized Chaos Game Representation and Deep Learning for Peptide/Protein Classification" @default.
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• W4296023635 doi "https://doi.org/10.1101/2022.09.10.507145" @default.
• W4296023635 hasPublicationYear "2022" @default.
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