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- W4296036584 abstract "Background This analysis describes participants’ opioid use disorder (OUD) outcomes for 18 months after discontinuing extended-release buprenorphine injection (BUP-XR, SUBLOCADE). Methods The RECOVER (Remission From Chronic Opioid Use: Studying Environmental and Socioeconomic Factors on Recovery) study recruited participants from BUP-XR clinical trials (NCT02357901, NCT025100142, and NCT02896296) to assess whether there were sustained benefits after leaving the trial. Abstinence from opioids and from all illicit substances (excluding medical cannabis), health-related quality of life, depression, and employment were measured after BUP-XR discontinuation and change in outcomes assessed at 6, 12, and 18 months. Results were analyzed within the full cohort and by duration of BUP-XR treatment (0–2 months, 3–5 months, 6–11 months, 12 months, or 13–18 months) with and without inverse probability weights adjusting for differences in baseline characteristics. Results Of 533 participants, 529 were assessed over the 18-month study period. Further posttrial pharmacotherapy was reported by 33% of participants. At RECOVER baseline, longer BUP-XR was associated with higher abstinence (0–2 months BUP-XR [n = 116]: 38.8%; 3–5 months BUP-XR [n = 61]: 41.0%; 6–11 months BUP-XR [n = 86]: 68.6%; 12 months BUP-XR [n = 135]: 71.9%; 18 months BUP-XR [n = 131]: 88.2%) and greater 12-Item Short Form Health Survey mental component scores. Over 60% of participants had stable or improved outcomes at 6, 12, and 18 months assessments. Overall 47% of participants self-reported sustained opioid abstinence for the full 18-month follow-up, with greater sustained abstinence associated with longer BUP-XR treatment duration. A sensitivity analysis, removing patients receiving medications for OUD, yielded similar results. Conclusions Participants from BUP-XR clinical trials who continued into RECOVER maintained or improved on numerous outcomes over 18 months, demonstrating the long-term positive impact of OUD pharmacotherapy." @default.
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- W4296036584 date "2022-09-16" @default.
- W4296036584 modified "2023-10-16" @default.
- W4296036584 title "Continued Posttrial Benefits of Buprenorphine Extended Release: RECOVER Study Findings" @default.
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- W4296036584 doi "https://doi.org/10.1097/adm.0000000000001070" @default.
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