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- W4296037710 abstract "The theranostic principle describes the diagnostic and therapeutic use of radioactive nuclides linked to biochemically active ligands. The oldest and most prominent field of application of theranostics in oncology is differentiated thyroid cancer treated by radioiodine therapy, which allows imaging of the iodine uptake and thus tumor manifestations by gamma (γ) radiation of radioiodine. Other areas of application include neuroendocrine tumors, castration-resistant prostate cancer and, in the context of individual therapeutic approaches, fibroblastic tumors. Imaging with beta-plus (β+) emitters is mainly performed using so-called hybrid imaging: positron emission tomography (PET) in combination with computed tomography or magnetic resonance imaging (PET/CT or PET/MRI). Beta-minus (β-) emitters are predominantly used in therapy, but the use of alpha (α) emitters is also increasing, thus, enabling targeted cancer treatment with mostly low-grade side effects.Das Prinzip der Theranostik beschreibt die sowohl diagnostische als auch therapeutische Nutzung radioaktiver Nuklide, geknüpft an biochemisch aktive Liganden. Das älteste und wohl bekannteste onkologische Einsatzgebiet der Theranostik ist das differenzierte Schilddrüsenkarzinom mit der Radiojodtherapie und der Möglichkeit, die Jodaufnahme und somit die Tumormanifestationen bildlich über die γ‑Strahlung des Radiojods darzustellen. Weitere Einsatzgebiete ergeben sich bei neuroendokrinen Tumoren, beim kastrationsresistenten Prostatakarzinom und individualtherapeutisch auch bei fibroblastischen Tumoren. Die Bildgebung erfolgt bei Verwendung von β+-Strahlern vornehmlich über die sogenannte Hybridbildgebung (Positronenemissionstomographie in der Kombination mit Computer- oder Magnetresonanztomographie). Bei der Therapie kommen vorwiegend β−-Strahler, jedoch auch zunehmend α‑Strahler zum Einsatz, sie ermöglichen eine zielgerichtete onkologische Therapie mit zumeist geringen Nebenwirkungen." @default.
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- W4296037710 date "2022-09-16" @default.
- W4296037710 modified "2023-10-18" @default.
- W4296037710 title "Onkologische Theranostik in der Nuklearmedizin" @default.
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- W4296037710 doi "https://doi.org/10.1007/s00117-022-01072-w" @default.
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