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- W4296041760 abstract "Abstract Aspergillus spp. mainly reproduce asexually via asexual spores called conidia. In this study, we identified CsgA, a conidia-specific Zn 2 Cys 6 transcription factor containing the GAL4-like zinc-finger domain, and characterized the roles of CsgA in the model organism Aspergillus nidulans . In A. nidulans , the Δ csgA strain produced abnormal conidiophores and exhibited increased conidial production. The deletion of csgA resulted in impaired production of sexual fruiting bodies (cleistothecia) and lower mutA expression levels. Overexpression of csgA led to decreased conidia production but increased cleistothecia production, suggesting that CsgA is essential for proper asexual and sexual development in A. nidulans . In conidia, the deletion of csgA resulted in increased trehalose content, higher spore viability, and increased tolerance to thermal and oxidative stresses. Transcriptomic analysis revealed that the loss of csgA affects the expression of genes related to conidia germination, DNA repair, and secondary metabolite biosynthesis. Further analysis revealed that the Δ csgA strain exhibited delayed conidial germination and abnormal germ tube length. Additionally, the production of sterigmatocystin increased in the Δ csgA conidia compared to that in the controls. Overall, these results suggest that CsgA is crucial for proper fungal development, spore viability, conidial germination, and sterigmatocystin production in A. nidulans ." @default.
- W4296041760 created "2022-09-17" @default.
- W4296041760 creator A5053895854 @default.
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- W4296041760 date "2022-09-16" @default.
- W4296041760 modified "2023-09-26" @default.
- W4296041760 title "The function of a conidia specific transcription factor CsgA in Aspergillus nidulans" @default.
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- W4296041760 doi "https://doi.org/10.1038/s41598-022-19749-6" @default.
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