FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296061657> ?p ?o ?g. }

• W4296061657 abstract "The survival outcome of triple-negative breast cancer (TNBC) remains poor, with difficulties still existing in prognosis assessment and patient stratification. Pyroptosis, a newly discovered form of programmed cell death, is involved in cancer pathogenesis and progression. The role of pyroptosis in the tumor microenvironment (TME) of TNBC has not been fully elucidated. In this study, we disclosed global alterations in 58 pyroptosis-related genes at somatic mutation and transcriptional levels in TNBC samples collected from The Cancer Genome Atlas and Gene Expression Omnibus databases. Based on the expression patterns of genes related to pyroptosis, we identified two molecular subtypes that harbored different TME characteristics and survival outcomes. Then, based on differentially expressed genes between two subtypes, we established a 12-gene score with robust efficacy in predicting short- and long-term overall survival of TNBC. Patients at low risk exhibited a significantly better prognosis, more antitumor immune cell infiltration, and higher expression of immune checkpoints including PD-1, PD-L1, CTLA-4, and LAG3. The comprehensive analysis of the immune landscape in TNBC indicated that alterations in pyroptosis-related genes were closely related to the formation of the immune microenvironment and the intensity of the anticancer response. The 12-gene score provided new information on the risk stratification and immunotherapy strategy for highly heterogeneous patients with TNBC." @default.
• W4296061657 created "2022-09-17" @default.
• W4296061657 creator A5000122749 @default.
• W4296061657 creator A5013134577 @default.
• W4296061657 creator A5037188176 @default.
• W4296061657 creator A5040786120 @default.
• W4296061657 creator A5062862687 @default.
• W4296061657 date "2022-09-16" @default.
• W4296061657 modified "2023-10-18" @default.
• W4296061657 title "Immune landscape and risk prediction based on pyroptosis-related molecular subtypes in triple-negative breast cancer" @default.
• W4296061657 cites W1979946545 @default.
• W4296061657 cites W2001212240 @default.
• W4296061657 cites W2029838192 @default.
• W4296061657 cites W2057187391 @default.
• W4296061657 cites W2077706404 @default.
• W4296061657 cites W2098683355 @default.
• W4296061657 cites W2109265522 @default.
• W4296061657 cites W2112434826 @default.
• W4296061657 cites W2112648444 @default.
• W4296061657 cites W2114630456 @default.
• W4296061657 cites W2123636561 @default.
• W4296061657 cites W2149668671 @default.
• W4296061657 cites W2462773201 @default.
• W4296061657 cites W2466558384 @default.
• W4296061657 cites W2504940557 @default.
• W4296061657 cites W2560367415 @default.
• W4296061657 cites W2567051070 @default.
• W4296061657 cites W2608757343 @default.
• W4296061657 cites W2620775812 @default.
• W4296061657 cites W2762153201 @default.
• W4296061657 cites W2771978163 @default.
• W4296061657 cites W2795941120 @default.
• W4296061657 cites W2796207838 @default.
• W4296061657 cites W2796494201 @default.
• W4296061657 cites W2798022026 @default.
• W4296061657 cites W2801058461 @default.
• W4296061657 cites W2805900947 @default.
• W4296061657 cites W2883471350 @default.
• W4296061657 cites W2895840881 @default.
• W4296061657 cites W2897422388 @default.
• W4296061657 cites W2943983202 @default.
• W4296061657 cites W2966710588 @default.
• W4296061657 cites W2967339341 @default.
• W4296061657 cites W2972758365 @default.
• W4296061657 cites W2979618235 @default.
• W4296061657 cites W2983652778 @default.
• W4296061657 cites W2987122119 @default.
• W4296061657 cites W2992466184 @default.
• W4296061657 cites W2998795792 @default.
• W4296061657 cites W3000078203 @default.
• W4296061657 cites W3006930853 @default.
• W4296061657 cites W3011500848 @default.
• W4296061657 cites W3012485477 @default.
• W4296061657 cites W3016393329 @default.
• W4296061657 cites W3036559517 @default.
• W4296061657 cites W3040249597 @default.
• W4296061657 cites W3084494759 @default.
• W4296061657 cites W3109853980 @default.
• W4296061657 cites W3112974929 @default.
• W4296061657 cites W3116724422 @default.
• W4296061657 cites W3128102381 @default.
• W4296061657 cites W3129378002 @default.
• W4296061657 cites W3130271765 @default.
• W4296061657 cites W3137135974 @default.
• W4296061657 cites W3143335768 @default.
• W4296061657 cites W3153020115 @default.
• W4296061657 cites W3154559539 @default.
• W4296061657 cites W3175173749 @default.
• W4296061657 cites W3178402802 @default.
• W4296061657 cites W3179860179 @default.
• W4296061657 cites W3185336537 @default.
• W4296061657 cites W3193657573 @default.
• W4296061657 cites W3195292091 @default.
• W4296061657 cites W3195706932 @default.
• W4296061657 cites W3200608395 @default.
• W4296061657 cites W3204698434 @default.
• W4296061657 cites W3212471117 @default.
• W4296061657 cites W3213834237 @default.
• W4296061657 cites W4200308452 @default.
• W4296061657 cites W4206769087 @default.
• W4296061657 cites W4220730309 @default.
• W4296061657 cites W4220950726 @default.
• W4296061657 cites W4281663502 @default.
• W4296061657 doi "https://doi.org/10.3389/fimmu.2022.933703" @default.
• W4296061657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36189269" @default.
• W4296061657 hasPublicationYear "2022" @default.
• W4296061657 type Work @default.
• W4296061657 citedByCount "5" @default.
• W4296061657 countsByYear W42960616572023 @default.
• W4296061657 crossrefType "journal-article" @default.
• W4296061657 hasAuthorship W4296061657A5000122749 @default.
• W4296061657 hasAuthorship W4296061657A5013134577 @default.
• W4296061657 hasAuthorship W4296061657A5037188176 @default.
• W4296061657 hasAuthorship W4296061657A5040786120 @default.
• W4296061657 hasAuthorship W4296061657A5062862687 @default.
• W4296061657 hasBestOaLocation W42960616571 @default.
• W4296061657 hasConcept C121608353 @default.
• W4296061657 hasConcept C126322002 @default.
• W4296061657 hasConcept C143998085 @default.
• W4296061657 hasConcept C17172800 @default.

• next