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- W4296064744 abstract "A recent report from my laboratory has revealed the force–velocity relationship of actin polymerization at the contact point with the lamellipodium tip plasma membrane. The results are consistent with the curve predicted by the Brownian ratchet theory. Notably, under the conditions in lamellipodia where the load on each actin barbed end is kept low by constant retrograde actin flow and densely packed actin filaments, traction force applied to the lamellipodium tip greatly promotes actin elongation, leading to gradual cell protrusion. The Brownian ratchet theory thus provides an account of how cells sense the force from the outer environment to change the direction of protrusion and migration. Considering the large quantity of locally promoted actin polymerization, the “tip actin polymerization force sensor” may be the common and the most effective force sensor in non-excitable animal cells. Cells appear to use the Brownian ratchet to collect “information” for their movement. This chapter provides a biological and biophysical overview of the force regulation of actin polymerization at the lamellipodium tip, including a brief comparison with the “information ratchet” concept." @default.
- W4296064744 created "2022-09-17" @default.
- W4296064744 creator A5012216001 @default.
- W4296064744 date "2023-01-01" @default.
- W4296064744 modified "2023-09-23" @default.
- W4296064744 title "Brownian ratchet force sensor at the contacting point between F-actin barbed end and lamellipodium tip plasma membrane" @default.
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- W4296064744 doi "https://doi.org/10.1016/b978-0-323-89911-6.00015-7" @default.
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