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- W4296068304 abstract "The molar enthalpies of dissolution of N-tetramethylglycoluril, a known psychotropically active pharmaceutical mebicar (Meb) (solute x), in aqueous solutions of d-monosaccharide glucose (Glu), fructose (Fru) and galactose (Gal) as well as disaccharide sucrose (Suc) and α-lactose (Lac) (cosolute y), were measured by the precision calorimetry method at T = 298.15 K and ambient pressure. Unlike the heat absorption in aqueous monosaccharides or Lac, the endothermicity of Meb dissolution in {water (W) + Suc} decreases as the sugar content becomes higher. The enthalpy-heterotactic coefficients for pair interactions between the solute and cosolute molecules, hxy, were determined using the McMillan-Mayer theory formalism. Similar to the homotactic parameters hyy, the hxy values (in J·kg·mol−2) were found to be positive, increasing in the series Suc (86) ≪ Lac (3 2 9) < Fru (4 5 6) < Glu (5 4 5) < Gal (6 6 3), despite the existing unusually large (in magnitude) negative hxx value, which is about −2000 J·kg·mol−2. Overall, the number of hydroxy groups and their axial(a)/equatorial(e) positions as well as the peculiarities of a glycoside bond and intramolecular H-bonding in cosolute saccharide molecules cause a stereospecificity of Meb hydration manifested in pair-interaction enthalpic coefficients hxy. So, the inequality hxy > hyy was found to be characteristic of monosaccharide containing aqueous Meb solutions (down to hyy ≈ 0.2hxy for Gal), and hxy < hyy – to be related to disaccharide containing aqueous Meb solutions. Thus, if hxy for (W + Lac + Meb) is ca. 0.65hyy, then it is only about 0.15hyy in the case of (W + Suc + Meb)." @default.
- W4296068304 created "2022-09-17" @default.
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- W4296068304 date "2022-12-01" @default.
- W4296068304 modified "2023-09-29" @default.
- W4296068304 title "Enthalpy-related parameters of interaction of sucrose, lactose and their monosaccharide constituents with the mebicar (N-tetramethylglycoluril) drug in an aqueous medium at 298.15 K" @default.
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- W4296068304 doi "https://doi.org/10.1016/j.molliq.2022.120375" @default.
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