FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296077749> ?p ?o ?g. }

• W4296077749 abstract "Abstract Background: OCRL (Oculocerebrorenal syndrome of Lowe Protein) was originally well-known as the Lowe’s protein. However, the expression, significance and regulation mechanisms of OCRL in any cancers were not clear. Methods: The bioinformation of breast cancer (BC) patients was required from TCGA (The Cancer Genome Atlas), and the expression was validated via IHC (immuno-histochemical analysis), qPCR and western blot. The UALCAN database was used to explore the promoter methylation level of OCRL and its role in gene silencing and survival. The prognostic roles of various clinicopathologic characteristics, including the OCRL, were evaluated by univariate and multivariate regression analysis. OCRL-related differentially expressed genes (DEGs) and their functions were explored by LinkedOmics database. The protein-protein interaction (PPI) and immunomodulatory roles were further analyzed with STRING and TISIDB database. Results: Compared with normal and paracancerous samples, the up-regulated expression of OCRL was identified in BC samples. The OCRL was co-expressed with a variety of unfavorable survival-related genes, which also was identified as an independent prognostic factor. Thus, the prognosis of BC patients with overexpressed OCRL was notably more unfavorable from TCGA database. Also, the hypomethylation of OCRL at certain sites was associated with gene silencing and poor survival. Moreover, the overexpression level of OCRL was negatively associated with the infiltration of the most immune cells and the expression of various immune biomarkers in BC. Finally, a OCRL expression-based nomogram integrating independent prognostic factors was constructed to predict at one-, five-, and ten-year the overall survival (OS). Conclusion: OCRL was a promising prognostic predictor and potential immune inhibition modulator." @default.
• W4296077749 created "2022-09-17" @default.
• W4296077749 creator A5004553785 @default.
• W4296077749 creator A5004705463 @default.
• W4296077749 creator A5005971604 @default.
• W4296077749 creator A5025285555 @default.
• W4296077749 creator A5027183560 @default.
• W4296077749 creator A5051881158 @default.
• W4296077749 creator A5067471098 @default.
• W4296077749 date "2022-09-16" @default.
• W4296077749 modified "2023-10-03" @default.
• W4296077749 title "OCRL is a novel prognostic biomarker and its association with immunoregulation in breast cancer" @default.
• W4296077749 cites W1982092900 @default.
• W4296077749 cites W2030958832 @default.
• W4296077749 cites W2039123767 @default.
• W4296077749 cites W2042699075 @default.
• W4296077749 cites W2043299973 @default.
• W4296077749 cites W2049491375 @default.
• W4296077749 cites W2130363876 @default.
• W4296077749 cites W2345415641 @default.
• W4296077749 cites W2530700542 @default.
• W4296077749 cites W2560406314 @default.
• W4296077749 cites W2560409587 @default.
• W4296077749 cites W2560836545 @default.
• W4296077749 cites W2728274349 @default.
• W4296077749 cites W2736730167 @default.
• W4296077749 cites W2777125604 @default.
• W4296077749 cites W2779695949 @default.
• W4296077749 cites W2914643394 @default.
• W4296077749 cites W2951071083 @default.
• W4296077749 cites W2971711960 @default.
• W4296077749 cites W2999417355 @default.
• W4296077749 cites W3128646645 @default.
• W4296077749 cites W3135755572 @default.
• W4296077749 cites W3159754282 @default.
• W4296077749 cites W3195237310 @default.
• W4296077749 cites W4205724345 @default.
• W4296077749 cites W4214507324 @default.
• W4296077749 cites W4220963974 @default.
• W4296077749 cites W4280604224 @default.
• W4296077749 doi "https://doi.org/10.21203/rs.3.rs-2032108/v1" @default.
• W4296077749 hasPublicationYear "2022" @default.
• W4296077749 type Work @default.
• W4296077749 citedByCount "0" @default.
• W4296077749 crossrefType "posted-content" @default.
• W4296077749 hasAuthorship W4296077749A5004553785 @default.
• W4296077749 hasAuthorship W4296077749A5004705463 @default.
• W4296077749 hasAuthorship W4296077749A5005971604 @default.
• W4296077749 hasAuthorship W4296077749A5025285555 @default.
• W4296077749 hasAuthorship W4296077749A5027183560 @default.
• W4296077749 hasAuthorship W4296077749A5051881158 @default.
• W4296077749 hasAuthorship W4296077749A5067471098 @default.
• W4296077749 hasBestOaLocation W42960777491 @default.
• W4296077749 hasConcept C104317684 @default.
• W4296077749 hasConcept C119056186 @default.
• W4296077749 hasConcept C126322002 @default.
• W4296077749 hasConcept C143998085 @default.
• W4296077749 hasConcept C150194340 @default.
• W4296077749 hasConcept C190727270 @default.
• W4296077749 hasConcept C33288867 @default.
• W4296077749 hasConcept C502942594 @default.
• W4296077749 hasConcept C54355233 @default.
• W4296077749 hasConcept C71924100 @default.
• W4296077749 hasConcept C86803240 @default.
• W4296077749 hasConceptScore W4296077749C104317684 @default.
• W4296077749 hasConceptScore W4296077749C119056186 @default.
• W4296077749 hasConceptScore W4296077749C126322002 @default.
• W4296077749 hasConceptScore W4296077749C143998085 @default.
• W4296077749 hasConceptScore W4296077749C150194340 @default.
• W4296077749 hasConceptScore W4296077749C190727270 @default.
• W4296077749 hasConceptScore W4296077749C33288867 @default.
• W4296077749 hasConceptScore W4296077749C502942594 @default.
• W4296077749 hasConceptScore W4296077749C54355233 @default.
• W4296077749 hasConceptScore W4296077749C71924100 @default.
• W4296077749 hasConceptScore W4296077749C86803240 @default.
• W4296077749 hasLocation W42960777491 @default.
• W4296077749 hasOpenAccess W4296077749 @default.
• W4296077749 hasPrimaryLocation W42960777491 @default.
• W4296077749 hasRelatedWork W1519915707 @default.
• W4296077749 hasRelatedWork W1990232189 @default.
• W4296077749 hasRelatedWork W2002128513 @default.
• W4296077749 hasRelatedWork W2052965733 @default.
• W4296077749 hasRelatedWork W2064587649 @default.
• W4296077749 hasRelatedWork W2084654188 @default.
• W4296077749 hasRelatedWork W2086524534 @default.
• W4296077749 hasRelatedWork W2144428165 @default.
• W4296077749 hasRelatedWork W2417387999 @default.
• W4296077749 hasRelatedWork W4248284651 @default.
• W4296077749 isParatext "false" @default.
• W4296077749 isRetracted "false" @default.
• W4296077749 workType "article" @default.