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- W4296079941 abstract "Abstract Background Insulin producing cells generated by liver cell transdifferentiation, could serve as an attractive source for regenerative medicine. The present study assesses the relationship between DNA methylation pTFs induced liver to pancreas transdifferentiation. Results The transdifferentiation process is associated with DNA demethylation, mainly at gene regulatory sites, and with increased expression of these genes. Active inhibition of DNA methylation promotes the pancreatic transcription factor-induced transdifferentiation process, supporting a causal role for DNA demethylation in this process. Conclusions Transdifferentiation is associated with global DNA hypomethylation, and with increased expression of specific demethylated genes. A combination of epigenetic modulators may be used to increase chromatin accessibility of the pancreatic transcription factors, thus promoting the efficiency of the developmental process." @default.
- W4296079941 created "2022-09-17" @default.
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- W4296079941 date "2022-09-16" @default.
- W4296079941 modified "2023-09-26" @default.
- W4296079941 title "The role of DNA demethylation in liver to pancreas transdifferentiation" @default.
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- W4296079941 doi "https://doi.org/10.1186/s13287-022-03159-6" @default.
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