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• W4296082461 abstract "Several factors have been reported to affect graft survival following kidney transplantation. CD52 molecules may increase T cell proliferation and activation, which may contribute to acute graft rejection and graft survival. In the current study, we studied the possible value of preoperative CD52 levels in predicting graft survival following renal transplantation. Ninety-six patients with end-stage renal disease who had kidney transplantation were included in the study from our prospective cohort. Blood samples were taken one day before surgery, and plasma CD52 levels were measured using ELISA (Cloud-Clone Corp., Houston, TX, USA). Acute rejection, acute tubular necrosis, delayed graft function, graft loss, BK infection, cytomegalovirus infection, and graft survival were evaluated. The mean age of recipients was <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mn>50.08</mn> <mo>±</mo> <mn>12.82</mn> <mtext> </mtext> <mtext>years</mtext> </math> , and 64.6% were male. The incidence of delayed graft function, acute rejection, graft loss ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M2> <mi>p</mi> <mo><</mo> <mn>0.01</mn> </math> ), BK virus infection, and serum creatinine levels were significantly higher in recipients with high preoperative CD52 levels six months after transplantation ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M3> <mi>p</mi> <mo><</mo> <mn>0.05</mn> </math> ). Kaplan–Meier analysis revealed that three-year graft survival was significantly higher in patients with low preoperative CD52 levels ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M4> <mi>p</mi> <mo><</mo> <mn>0.0001</mn> </math> ). Univariate and multivariate Cox regression analyses showed that serum creatinine levels ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M5> <mtext>hazard</mtext> <mtext> </mtext> <mtext>ratio</mtext> <mtext> </mtext> <mfenced open=[ close=]> <mrow> <mtext>HR</mtext> </mrow> </mfenced> <mo>=</mo> <mn>1.7</mn> </math> , <math xmlns=http://www.w3.org/1998/Math/MathML id=M6> <mi>p</mi> <mo><</mo> <mn>0.05</mn> </math> ), acute rejection ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M7> <mtext>HR</mtext> <mo>=</mo> <mn>2.919</mn> </math> , <math xmlns=http://www.w3.org/1998/Math/MathML id=M8> <mi>p</mi> <mo><</mo> <mn>0.05</mn> </math> ), and preoperative CD52 levels ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M9> <mtext>HR</mtext> <mo>=</mo> <mn>3.114</mn> </math> , <math xmlns=http://www.w3.org/1998/Math/MathML id=M10> <mi>p</mi> <mo><</mo> <mn>0.05</mn> </math> ) were independent prognostic factors for graft survival after kidney transplantation. We showed that high preoperative CD52 levels are associated with higher rates of acute rejection, delayed graft function, and BK virus infection and lower rates of graft survival after kidney transplantation." @default.
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• W4296082461 date "2022-09-16" @default.
• W4296082461 modified "2023-09-30" @default.
• W4296082461 title "Preoperative CD52 Level Predicts Graft Survival following Kidney Transplantation" @default.
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• W4296082461 doi "https://doi.org/10.1155/2022/8949919" @default.
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