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- W4296088765 abstract "Abstract Neoplasms are common across the animal kingdom and seem to be a feature plesiomorphic for metazoans, related with an increase in somatic complexity. The fossil record of cancer complements our knowledge of the origin of neoplasms and vulnerability of various vertebrate taxa. Here, we document the first undoubted record of primary malignant bone tumour in a Mesozoic non-amniote. The diagnosed osteosarcoma developed in the vertebral intercentrum of a temnospondyl amphibian, Metoposaurus krasiejowensis from the Krasiejów locality, southern Poland. A wide array of data collected from gross anatomy and microstructure of the affected intercentrum reveals the tumour growth dynamics and pathophysiological aspects of the neoplasm formation on the histological level. The neoplastic bone mimics on the structural level the fast growing fibrolamellar bone, but on the histological level develops through a novel ossification type. The physiological process of bone remodelling inside the endochondral domain continued uninterrupted across the pathology of the periosteal part. Based on the results, we discuss our case study’s consistence with the Tissue Organization Field Theory of tumorigenesis, which locates the causes of neoplastic transformations in disorders of tissue architecture." @default.
- W4296088765 created "2022-09-17" @default.
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- W4296088765 date "2022-09-15" @default.
- W4296088765 modified "2023-10-16" @default.
- W4296088765 title "An insight into cancer palaeobiology: Does the Mesozoic neoplasm support Tissue Organization Field Theory of tumorigenesis?" @default.
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- W4296088765 doi "https://doi.org/10.21203/rs.3.rs-2053786/v1" @default.
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