FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296101600> ?p ?o ?g. }

• W4296101600 abstract "Post-transcriptional regulation in multicellular organisms is mediated by microRNAs. However, the principles that determine if a gene is regulated by miRNAs are poorly understood. Previous works focused mostly on miRNA seed matches and other features of the 3'-UTR of transcripts. These common approaches rely on knowledge of the miRNA families, and computational approaches still yield poor, inconsistent results, with many false positives. In this work, we present a different paradigm for predicting miRNA-regulated genes based on the encoded proteins. In a novel, automated machine learning framework, we use sequence as well as diverse functional annotations to train models on multiple organisms using experimentally validated data. We present insights from tens of millions of features extracted and ranked from different modalities. We show high predictive performance per organism and in generalization across species. We provide a list of novel predictions including Danio rerio (zebrafish) and Arabidopsis thaliana (mouse-ear cress). We compare genomic models and observe that our protein model outperforms, whereas a unified model improves on both. While most membranous and disease related proteins are regulated by miRNAs, the G-protein coupled receptor (GPCR) family is an exception, being mostly unregulated by miRNAs. We further show that the evolutionary conservation among paralogs does not imply any coherence in miRNA regulation. We conclude that duplicated paralogous genes that often changed their function, also diverse in their tendency to be miRNA regulated. We conclude that protein function is informative across species in predicting post-transcriptional miRNA regulation in living cells." @default.
• W4296101600 created "2022-09-17" @default.
• W4296101600 creator A5026544660 @default.
• W4296101600 creator A5045008246 @default.
• W4296101600 date "2022-09-08" @default.
• W4296101600 modified "2023-10-05" @default.
• W4296101600 title "Inferring microRNA regulation: A proteome perspective" @default.
• W4296101600 cites W1566143144 @default.
• W4296101600 cites W1968631483 @default.
• W4296101600 cites W1988925753 @default.
• W4296101600 cites W1989493946 @default.
• W4296101600 cites W2026570544 @default.
• W4296101600 cites W2037691883 @default.
• W4296101600 cites W2045849438 @default.
• W4296101600 cites W2049319343 @default.
• W4296101600 cites W2055660539 @default.
• W4296101600 cites W2069795758 @default.
• W4296101600 cites W2082280814 @default.
• W4296101600 cites W2090219560 @default.
• W4296101600 cites W2094019030 @default.
• W4296101600 cites W2098833298 @default.
• W4296101600 cites W2117977572 @default.
• W4296101600 cites W2120583228 @default.
• W4296101600 cites W2126456089 @default.
• W4296101600 cites W2149049580 @default.
• W4296101600 cites W2150863405 @default.
• W4296101600 cites W2154866420 @default.
• W4296101600 cites W2156132904 @default.
• W4296101600 cites W2156133650 @default.
• W4296101600 cites W2158135353 @default.
• W4296101600 cites W2159767268 @default.
• W4296101600 cites W2171260596 @default.
• W4296101600 cites W2174734928 @default.
• W4296101600 cites W2252523470 @default.
• W4296101600 cites W2280346092 @default.
• W4296101600 cites W2288482887 @default.
• W4296101600 cites W2435559048 @default.
• W4296101600 cites W2519117646 @default.
• W4296101600 cites W2554050349 @default.
• W4296101600 cites W2560678530 @default.
• W4296101600 cites W2604726868 @default.
• W4296101600 cites W2619629891 @default.
• W4296101600 cites W2768177014 @default.
• W4296101600 cites W2768632638 @default.
• W4296101600 cites W2811212358 @default.
• W4296101600 cites W2898440040 @default.
• W4296101600 cites W2919470997 @default.
• W4296101600 cites W2993347499 @default.
• W4296101600 cites W2994306223 @default.
• W4296101600 cites W2998880131 @default.
• W4296101600 cites W3004075535 @default.
• W4296101600 cites W3035353528 @default.
• W4296101600 cites W3110575802 @default.
• W4296101600 cites W3144701084 @default.
• W4296101600 cites W3175257329 @default.
• W4296101600 cites W3201998632 @default.
• W4296101600 cites W3205640215 @default.
• W4296101600 cites W4200056405 @default.
• W4296101600 cites W4226172016 @default.
• W4296101600 cites W4246271082 @default.
• W4296101600 cites W4252232449 @default.
• W4296101600 cites W4255156463 @default.
• W4296101600 doi "https://doi.org/10.3389/fmolb.2022.916639" @default.
• W4296101600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36158574" @default.
• W4296101600 hasPublicationYear "2022" @default.
• W4296101600 type Work @default.
• W4296101600 citedByCount "2" @default.
• W4296101600 countsByYear W42961016002023 @default.
• W4296101600 crossrefType "journal-article" @default.
• W4296101600 hasAuthorship W4296101600A5026544660 @default.
• W4296101600 hasAuthorship W4296101600A5045008246 @default.
• W4296101600 hasBestOaLocation W42961016001 @default.
• W4296101600 hasConcept C104317684 @default.
• W4296101600 hasConcept C104397665 @default.
• W4296101600 hasConcept C119857082 @default.
• W4296101600 hasConcept C14036430 @default.
• W4296101600 hasConcept C145059251 @default.
• W4296101600 hasConcept C150194340 @default.
• W4296101600 hasConcept C162317418 @default.
• W4296101600 hasConcept C19843653 @default.
• W4296101600 hasConcept C2776878037 @default.
• W4296101600 hasConcept C41008148 @default.
• W4296101600 hasConcept C54355233 @default.
• W4296101600 hasConcept C64869954 @default.
• W4296101600 hasConcept C70721500 @default.
• W4296101600 hasConcept C74318829 @default.
• W4296101600 hasConcept C86803240 @default.
• W4296101600 hasConceptScore W4296101600C104317684 @default.
• W4296101600 hasConceptScore W4296101600C104397665 @default.
• W4296101600 hasConceptScore W4296101600C119857082 @default.
• W4296101600 hasConceptScore W4296101600C14036430 @default.
• W4296101600 hasConceptScore W4296101600C145059251 @default.
• W4296101600 hasConceptScore W4296101600C150194340 @default.
• W4296101600 hasConceptScore W4296101600C162317418 @default.
• W4296101600 hasConceptScore W4296101600C19843653 @default.
• W4296101600 hasConceptScore W4296101600C2776878037 @default.
• W4296101600 hasConceptScore W4296101600C41008148 @default.
• W4296101600 hasConceptScore W4296101600C54355233 @default.
• W4296101600 hasConceptScore W4296101600C64869954 @default.
• W4296101600 hasConceptScore W4296101600C70721500 @default.

• next