Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296123342> ?p ?o ?g. }
- W4296123342 endingPage "114743" @default.
- W4296123342 startingPage "114743" @default.
- W4296123342 abstract "With the aim of shedding some light on the mechanism of action of zinc(II) complexes in antiproliferative processes and molecular signaling pathways, three novel glycosylated zinc(II)-cryptolepine complexes, i.e., [Zn(QA1)Cl2] (Zn(QA1)), [Zn(QA2)Cl2] (Zn(QA2)), and [Zn(QA3)Cl2] (Zn(QA3)), were prepared by conjugating a glucose moiety with cryptolepine, followed by complexation of the resulting glycosylated cryptolepine compounds N-((1-(2-morpholinoethyl)-1H-1,2,3-triazol-4-yl)methyl)-benzofuro[3,2-b]quinolin-11-amine (QA1), 2-(4-((benzofuro[3,2-b]quinolin-11-ylamino)methyl)-1H-1,2,3-triazol-1-yl)ethan-1-ol (QA2), and (2S,3S,4R,5R,6S)-2-(4-((benzofuro[3,2-b]quinolin-11-ylamino)-methyl)-1H-1,2,3-triazol-1-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (QA3) with zinc(II), and their anticancer activity was evaluated. In MTT assays, Zn(QA1)-Zn(QA3) were more active against cisplatin-resistant ovarian SK-OV-3/DDP cancer cells (SK-OV-3cis) than ZnCl2 and the QA1-QA3 ligands, with IC50 values of 1.81 ± 0.50, 2.92 ± 0.32, and 1.01 ± 0.11 μM, respectively. Complexation of glycosylated cryptolepine QA3 with zinc(II) increased the antiproliferative activity of the ligand, suggesting that Zn(QA3) could act as a chaperone to deliver the active ligand intracellularly, in contrast with other cryptolepine metal complexes previously reported. In vivo and in vitro investigations suggested that Zn(QA3) exhibited enhanced anticancer activity with treatment effects comparable to those of the clinical drug cisplatin. Furthermore, Zn(QA1)-Zn(QA3) triggered SK-OV-3cis cell apoptosis through mitophagy pathways in the order Zn(QA1) > Zn(QA1) > Zn(QA2). These results demonstrate the potential of glycosylated zinc(II)-cryptolepine complexes for the development of chemotherapy drugs against cisplatin-resistant SK-OV-3cis cells." @default.
- W4296123342 created "2022-09-17" @default.
- W4296123342 creator A5022184782 @default.
- W4296123342 creator A5031431125 @default.
- W4296123342 creator A5032506971 @default.
- W4296123342 creator A5038113583 @default.
- W4296123342 creator A5038751077 @default.
- W4296123342 creator A5059996188 @default.
- W4296123342 creator A5063963657 @default.
- W4296123342 date "2022-12-01" @default.
- W4296123342 modified "2023-09-29" @default.
- W4296123342 title "Novel glycosylation zinc(II)–cryptolepine complexes perturb mitophagy pathways and trigger cancer cell apoptosis and autophagy in SK-OV-3/DDP cells" @default.
- W4296123342 cites W161836838 @default.
- W4296123342 cites W1638976038 @default.
- W4296123342 cites W1942048278 @default.
- W4296123342 cites W1956554244 @default.
- W4296123342 cites W1965469756 @default.
- W4296123342 cites W1973347210 @default.
- W4296123342 cites W1975085158 @default.
- W4296123342 cites W1975996322 @default.
- W4296123342 cites W1979395573 @default.
- W4296123342 cites W1982462327 @default.
- W4296123342 cites W1986894327 @default.
- W4296123342 cites W1992661805 @default.
- W4296123342 cites W1998736037 @default.
- W4296123342 cites W2004346062 @default.
- W4296123342 cites W2005078443 @default.
- W4296123342 cites W2017282219 @default.
- W4296123342 cites W2017385297 @default.
- W4296123342 cites W2031278133 @default.
- W4296123342 cites W2034124607 @default.
- W4296123342 cites W2038556246 @default.
- W4296123342 cites W2046361892 @default.
- W4296123342 cites W2061260890 @default.
- W4296123342 cites W2064881435 @default.
- W4296123342 cites W2066695813 @default.
- W4296123342 cites W2069467005 @default.
- W4296123342 cites W2073707228 @default.
- W4296123342 cites W2085640353 @default.
- W4296123342 cites W2085657843 @default.
- W4296123342 cites W2089227323 @default.
- W4296123342 cites W2091896084 @default.
- W4296123342 cites W2095013153 @default.
- W4296123342 cites W2110652761 @default.
- W4296123342 cites W2130907704 @default.
- W4296123342 cites W2177248785 @default.
- W4296123342 cites W2279452326 @default.
- W4296123342 cites W2322869984 @default.
- W4296123342 cites W2332405824 @default.
- W4296123342 cites W2337123977 @default.
- W4296123342 cites W2365470942 @default.
- W4296123342 cites W2490932348 @default.
- W4296123342 cites W2516463727 @default.
- W4296123342 cites W2542021661 @default.
- W4296123342 cites W2555147185 @default.
- W4296123342 cites W2596506471 @default.
- W4296123342 cites W2602503318 @default.
- W4296123342 cites W2611482803 @default.
- W4296123342 cites W2615814714 @default.
- W4296123342 cites W263343890 @default.
- W4296123342 cites W2638048573 @default.
- W4296123342 cites W2766614745 @default.
- W4296123342 cites W2773120666 @default.
- W4296123342 cites W2776012437 @default.
- W4296123342 cites W2789506780 @default.
- W4296123342 cites W2794060187 @default.
- W4296123342 cites W2794759334 @default.
- W4296123342 cites W2795757718 @default.
- W4296123342 cites W2802017261 @default.
- W4296123342 cites W2807577568 @default.
- W4296123342 cites W2840700903 @default.
- W4296123342 cites W2884844055 @default.
- W4296123342 cites W2891064748 @default.
- W4296123342 cites W2892828835 @default.
- W4296123342 cites W2893692955 @default.
- W4296123342 cites W2897458056 @default.
- W4296123342 cites W2901667029 @default.
- W4296123342 cites W2910372584 @default.
- W4296123342 cites W2916376485 @default.
- W4296123342 cites W2936711569 @default.
- W4296123342 cites W2943134721 @default.
- W4296123342 cites W2945621579 @default.
- W4296123342 cites W2947583627 @default.
- W4296123342 cites W2951834394 @default.
- W4296123342 cites W2953034397 @default.
- W4296123342 cites W2963035169 @default.
- W4296123342 cites W2974342225 @default.
- W4296123342 cites W2975208930 @default.
- W4296123342 cites W2978219792 @default.
- W4296123342 cites W2990399898 @default.
- W4296123342 cites W2996729307 @default.
- W4296123342 cites W2998756496 @default.
- W4296123342 cites W2999756934 @default.
- W4296123342 cites W3001825355 @default.
- W4296123342 cites W3003760952 @default.
- W4296123342 cites W3009241446 @default.
- W4296123342 cites W3009874026 @default.
- W4296123342 cites W3011279840 @default.