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- W4296131484 abstract "Abstract Background 6-Pyruvoyl-tetrahydropterin synthase (PTPS) deficiency is an autosomal recessive disorder caused by PTS gene mutations. The aim of this study was to collect all PTS gene variants detected among Iranian patients with PTPS deficiency as well as in the Iranome project and classify them based on American College of Medical Genetics and Genomics (ACMG-AMP) guidelines. Results The number of PTS gene variants reported among Iranian PTPS patients and in the Iranome project were 19 and 36, respectively. Given that one variant was reported in both of our sources, the total number of variants was 54. These variants were classified as pathogenic ( n = 11), likely pathogenic ( n = 7), VUS ( n = 23), likely benign ( n = 1), and benign ( n = 12). Out of 19 variants reported among Iranian PTPS patients, c.155A>G (p.Asn52Ser, rs104894275) and c.317C>T (p.Thr106Met, rs200712908) were the most frequent ones, each with a frequency of 10%. c.84-3C>G (rs1230781262) (7.5%) and c.281A>T (p.Asp94Val) (5%) were in the next ranks of the list of variants. Conclusions The ACMG-AMP criteria need to be updated depending on the type of disease. In addition, to the best of our knowledge, no template has been described for classifying the variants identified in PTPS deficiency. Therefore, this study can be a good reference for future studies in this subject." @default.
- W4296131484 created "2022-09-17" @default.
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- W4296131484 date "2022-09-15" @default.
- W4296131484 modified "2023-10-18" @default.
- W4296131484 title "In silico analysis and the pathogenicity classification of PTS gene variants among Iranian population" @default.
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- W4296131484 doi "https://doi.org/10.1186/s43042-022-00351-4" @default.
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