FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296151569> ?p ?o ?g. }

• W4296151569 abstract "Abdominal aortic aneurysms have a high mortality rate. While surgery is the preferred treatment method, the biological repair of abdominal aortic aneurysms is being increasingly studied. We performed cellular and animal experiments to investigate the simultaneous function and mechanism of fibroblast growth factor 18 and integrin β1 in the biological repair of abdominal aortic aneurysms.Endothelial and smooth muscle cells of rat arteries were used for the cellular experiments. Intracellular integrin β1 expression was regulated through lentiviral transfection. Interventions with fibroblast growth factor 18 were determined according to the experimental protocol. Several methods were used to detect the expression of elastic fiber component proteins, cell proliferation, and migratory activity of endothelial and smooth muscle cells after different treatments. For animal experiments, abdominal aortic aneurysms were induced in rats by wrapping the abdominal aortae in sterile cotton balls soaked with CaCl2 solution. Fibroblast growth factor 18 was administered through tail vein injections. The local expression of integrin β1 was regulated through lentiviral injections into the adventitia of the abdominal aortic aneurysms. The abdominal aortae were harvested for pathological examinations and tensile mechanical tests.The expression of integrin β1 in endothelial and smooth muscle cells could be regulated effectively through lentiviral transfection. Animal and cellular experiments showed that fibroblast growth factor 18 + integrin β1 could improve the expression of elastic fiber component proteins and enhance the migratory and proliferative activities of smooth muscle and endothelial cells. Moreover, animal experiments showed that fibroblast growth factor 18 + integrin β1 could enhance the aortic integrity to withstand stretch of aortic aneurysm tissue.Fibroblast growth factor 18 + integrin β1 improved the biological repair of abdominal aortic aneurysms in rats by increasing the expression of elastic proteins, improving the migratory and proliferative abilities of endothelial and smooth muscle cells, and improving aortic remodeling." @default.
• W4296151569 created "2022-09-17" @default.
• W4296151569 creator A5036085392 @default.
• W4296151569 creator A5041104854 @default.
• W4296151569 creator A5055798270 @default.
• W4296151569 creator A5062215526 @default.
• W4296151569 creator A5070932000 @default.
• W4296151569 creator A5080922977 @default.
• W4296151569 date "2022-09-17" @default.
• W4296151569 modified "2023-09-27" @default.
• W4296151569 title "The synergistic mechanism of fibroblast growth factor 18 and integrin β1 in rat abdominal aortic aneurysm repair" @default.
• W4296151569 cites W1963837138 @default.
• W4296151569 cites W1990566772 @default.
• W4296151569 cites W2012702539 @default.
• W4296151569 cites W2058190957 @default.
• W4296151569 cites W2070155329 @default.
• W4296151569 cites W2100281491 @default.
• W4296151569 cites W2110143857 @default.
• W4296151569 cites W2139197862 @default.
• W4296151569 cites W2171037554 @default.
• W4296151569 cites W2570738377 @default.
• W4296151569 cites W2593443191 @default.
• W4296151569 cites W2760759058 @default.
• W4296151569 cites W2795375387 @default.
• W4296151569 cites W2894318233 @default.
• W4296151569 cites W2902783010 @default.
• W4296151569 cites W2912711077 @default.
• W4296151569 cites W2954555739 @default.
• W4296151569 cites W2958131751 @default.
• W4296151569 cites W2958762868 @default.
• W4296151569 cites W2967398248 @default.
• W4296151569 cites W2982017672 @default.
• W4296151569 cites W3008229330 @default.
• W4296151569 cites W3049008303 @default.
• W4296151569 cites W3082867800 @default.
• W4296151569 cites W3093970028 @default.
• W4296151569 cites W3212457357 @default.
• W4296151569 doi "https://doi.org/10.1186/s12872-022-02851-y" @default.
• W4296151569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36115958" @default.
• W4296151569 hasPublicationYear "2022" @default.
• W4296151569 type Work @default.
• W4296151569 citedByCount "1" @default.
• W4296151569 countsByYear W42961515692022 @default.
• W4296151569 crossrefType "journal-article" @default.
• W4296151569 hasAuthorship W4296151569A5036085392 @default.
• W4296151569 hasAuthorship W4296151569A5041104854 @default.
• W4296151569 hasAuthorship W4296151569A5055798270 @default.
• W4296151569 hasAuthorship W4296151569A5062215526 @default.
• W4296151569 hasAuthorship W4296151569A5070932000 @default.
• W4296151569 hasAuthorship W4296151569A5080922977 @default.
• W4296151569 hasBestOaLocation W42961515691 @default.
• W4296151569 hasConcept C126322002 @default.
• W4296151569 hasConcept C141071460 @default.
• W4296151569 hasConcept C142724271 @default.
• W4296151569 hasConcept C170493617 @default.
• W4296151569 hasConcept C195687474 @default.
• W4296151569 hasConcept C2776098176 @default.
• W4296151569 hasConcept C2776716733 @default.
• W4296151569 hasConcept C2779993416 @default.
• W4296151569 hasConcept C2780381497 @default.
• W4296151569 hasConcept C54355233 @default.
• W4296151569 hasConcept C71924100 @default.
• W4296151569 hasConcept C81885089 @default.
• W4296151569 hasConcept C86803240 @default.
• W4296151569 hasConcept C95444343 @default.
• W4296151569 hasConceptScore W4296151569C126322002 @default.
• W4296151569 hasConceptScore W4296151569C141071460 @default.
• W4296151569 hasConceptScore W4296151569C142724271 @default.
• W4296151569 hasConceptScore W4296151569C170493617 @default.
• W4296151569 hasConceptScore W4296151569C195687474 @default.
• W4296151569 hasConceptScore W4296151569C2776098176 @default.
• W4296151569 hasConceptScore W4296151569C2776716733 @default.
• W4296151569 hasConceptScore W4296151569C2779993416 @default.
• W4296151569 hasConceptScore W4296151569C2780381497 @default.
• W4296151569 hasConceptScore W4296151569C54355233 @default.
• W4296151569 hasConceptScore W4296151569C71924100 @default.
• W4296151569 hasConceptScore W4296151569C81885089 @default.
• W4296151569 hasConceptScore W4296151569C86803240 @default.
• W4296151569 hasConceptScore W4296151569C95444343 @default.
• W4296151569 hasIssue "1" @default.
• W4296151569 hasLocation W42961515691 @default.
• W4296151569 hasLocation W42961515692 @default.
• W4296151569 hasLocation W42961515693 @default.
• W4296151569 hasLocation W42961515694 @default.
• W4296151569 hasLocation W42961515695 @default.
• W4296151569 hasOpenAccess W4296151569 @default.
• W4296151569 hasPrimaryLocation W42961515691 @default.
• W4296151569 hasRelatedWork W1969016283 @default.
• W4296151569 hasRelatedWork W1977020874 @default.
• W4296151569 hasRelatedWork W2022988492 @default.
• W4296151569 hasRelatedWork W2149887676 @default.
• W4296151569 hasRelatedWork W2155189933 @default.
• W4296151569 hasRelatedWork W2614112610 @default.
• W4296151569 hasRelatedWork W3165742891 @default.
• W4296151569 hasRelatedWork W4239542376 @default.
• W4296151569 hasRelatedWork W4246843703 @default.
• W4296151569 hasRelatedWork W4251619790 @default.
• W4296151569 hasVolume "22" @default.
• W4296151569 isParatext "false" @default.
• W4296151569 isRetracted "false" @default.

• next