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- W4296161455 abstract "A man in his mid-40s presented to hospital with confusion, headache and feeling generally unwell. He had had a total resection of a grade IV astrocytic glioma 1 year prior. Initial observations, blood tests and CT head scan were unremarkable for acute features to explain the patient's presentation. However, an MRI head scan on this admission demonstrated a clear communicating hydrocephalus with new abnormal leptomeningeal enhancement, consistent with leptomeningeal metastatic infiltration by glioma. Lumbar puncture cytology and biochemistry supported this interpretation. As a small district general hospital in rural Wales, we discuss the experience of diagnosis and coordination of specialist input from a multidisciplinary team. We share the challenges of managing leptomeningeal disease in the COVID-19 pandemic, in the context of the additional risks this presents with chemotherapy-induced immunosuppression." @default.
- W4296161455 created "2022-09-18" @default.
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- W4296161455 date "2022-09-01" @default.
- W4296161455 modified "2023-09-27" @default.
- W4296161455 title "Diagnosis and management of leptomeningeal disease secondary to grade IV astrocytic glioma" @default.
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- W4296161455 doi "https://doi.org/10.1136/bcr-2022-250943" @default.
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