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• W4296161960 abstract "In his 2015 State of the Union Address, President Barack Obama launched a novel proposal for precision medicine 1 Collins FS Varmus H. A new initiative on precision medicine. N Engl J Med. 2015; 372: 793-795 Crossref PubMed Scopus (3316) Google Scholar ,2 Congress.gov. S.3822 - genomics and personalized medicine act of 2006. Available at: https://www.congress.gov/bill/109th-congress/senate-bill/3822. Accessed on May 5, 2022. Google Scholar to treat, prevent, and cure chronic diseases, such as cancer, 3 Skoulidies F Li BT Dy GK Price TJ Falchook GS Wolf J Italiano A Schuler M Borghaei H Barlesi F Kato T Curioni-Fontecedro A Sacher A Spira A Ramalingam SS Takahashi T Besse B Anderson A Ang A Tran Q Mather O Henary H Ngarmchamnanrith G Friberg G Velcheti V Govindan R. Sotorasib for lung cancers with KRASp.G12c mutation. N Engl J Med. 2021; 384: 2371-2381 Crossref PubMed Scopus (464) Google Scholar , 4 Mauro MJ O'Dwyer ME Druker BJ ST1571, a tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia: validating the promise of molecularly targeted therapy. Cancer Chemother Pharmacol. 2001; 48: S77-S78 Crossref PubMed Scopus (29) Google Scholar , 5 Ross JS Slodkowska EA Symmans WF Pusztai L Ravdin PM Hortobagyi GN. The HER-2 receptor and breast cancer: 10 years of targeted anti-HER-2 therapy and personalized medicine. Oncologist. 2009; 14: 320-368 Crossref PubMed Scopus (920) Google Scholar , 6 Dokmanovic M Wu WJ. Monitoring trastuzumab resistance and cardiotoxicity: a tale of personalized medicine. Adv Clin Chem. 2015; 70: 95-130 Crossref PubMed Scopus (15) Google Scholar cystic fibrosis, 7 Chang EH Zabner J. Precision genomic medicine in cystic fibrosis. Clin Transl Sci. 2015; 8: 606-610 Crossref PubMed Scopus (23) Google Scholar and chronic myelogenous leukemia, 4 Mauro MJ O'Dwyer ME Druker BJ ST1571, a tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia: validating the promise of molecularly targeted therapy. Cancer Chemother Pharmacol. 2001; 48: S77-S78 Crossref PubMed Scopus (29) Google Scholar employing strategies that account for patient variability and discard the traditional broad category “one-size-fits-all”. In principle, this personalized approach promotes targeted diagnosis and therapeutics by integrating information from multiple sources, including digital health analytics, proteomics, imaging, and genomics. 8 Weldy CS Ashley EA. Towards precision medicine in heart failure. Nat Rev Cardiol. 2021; 18: 745-762 Crossref PubMed Scopus (16) Google Scholar , 9 Ashley EA. Toward precision medicine. Nat Rev Genet. 2016; 17: 507-522 Crossref PubMed Scopus (450) Google Scholar , 10 Ashley EA. The precision medicine initiative: a new national effort. JAMA. 2015; 313: 2119-2120 Crossref PubMed Scopus (361) Google Scholar , 11 Dainis AM Ashley EA. Cardiovascular precision medicine in the genomics era. JACC Basic Transl Sci. 2018; 3: 313-326 Crossref PubMed Scopus (46) Google Scholar , 12 Ware JS Roberts AM Cook SA. Next generation sequencing for clinical diagnostics and personalized medicine: implications for the next generation cardiologist. Heart. 2012; 98: 276-281 Crossref PubMed Scopus (42) Google Scholar" @default.
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• W4296161960 title "Personalized Treatment Strategies Effective in Hypertrophic Cardiomyopathy Do Not Rely on Genomics in 2022: A Different Tale of Precision Medicine" @default.
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• W4296161960 doi "https://doi.org/10.1016/j.amjcard.2022.07.033" @default.
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