FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296162782> ?p ?o ?g. }

• W4296162782 endingPage "114181" @default.
• W4296162782 startingPage "114181" @default.
• W4296162782 abstract "Traffic-related air pollution (TRAP) has been a common public health problem, which is associated with central nervous system dysfunction according to large-scale epidemiological studies. Current studies are mostly limited to artificial laboratory exposure environments and specific genetic mechanisms remain unclear. Therefore, we chose a real-world transportation environment to expose aged mice, transporting them from the laboratory to a 1-m-high dry platform inside the campus and tunnel, and the mice were exposed daily from 7 a.m. to 7 p.m. for 2, 4 and 12 weeks respectively. Compared with the control group (in campus), the memory function of mice in the experimental group (in tunnel) was significantly impaired in the Morris water maze test. TRAP exposure increased the number of activated microglia in the hippocampal DG, CA1, CA3 regions and dorsolateral prefrontal cortex (dPFC). And neuroinflammation and oxidative stress levels were up-regulated in both hippocampus and dPFC of aged mice. By screening the risk genes of Alzheimer's disease, we found the mRNA and protein levels of ABCA7 were down-regulated and those of PYK2 were up-regulated. The DNA methylation ratios increased in four CpG sites of abca7 promoter region and decreased in one CpG site of pyk2 promoter region, which were consistent with the altered expression of ABCA7 and PYK2. In conclusion, exposure to the real traffic environment impaired memory function and enhanced neuroinflammation and oxidative stress responses, which could be relevant to the altered expression and DNA methylation levels of ABCA7 and PYK2. Our work provides a new and promising understanding of the pathological mechanisms of cognitive impairment caused by traffic-related air pollution." @default.
• W4296162782 created "2022-09-18" @default.
• W4296162782 creator A5015928630 @default.
• W4296162782 creator A5020532478 @default.
• W4296162782 creator A5027240571 @default.
• W4296162782 creator A5037828672 @default.
• W4296162782 creator A5043474706 @default.
• W4296162782 creator A5045438428 @default.
• W4296162782 creator A5057311321 @default.
• W4296162782 creator A5064605523 @default.
• W4296162782 creator A5087506428 @default.
• W4296162782 date "2022-12-01" @default.
• W4296162782 modified "2023-10-16" @default.
• W4296162782 title "Exposure to a real traffic environment impairs brain cognition in aged mice" @default.
• W4296162782 cites W1966831629 @default.
• W4296162782 cites W1975893297 @default.
• W4296162782 cites W1977782719 @default.
• W4296162782 cites W1986611577 @default.
• W4296162782 cites W1999794509 @default.
• W4296162782 cites W2008579577 @default.
• W4296162782 cites W2034707849 @default.
• W4296162782 cites W2064874359 @default.
• W4296162782 cites W2082583591 @default.
• W4296162782 cites W2096790403 @default.
• W4296162782 cites W2115779804 @default.
• W4296162782 cites W2119581346 @default.
• W4296162782 cites W2129497119 @default.
• W4296162782 cites W2134787735 @default.
• W4296162782 cites W2145210308 @default.
• W4296162782 cites W2152119060 @default.
• W4296162782 cites W2163410184 @default.
• W4296162782 cites W2321191430 @default.
• W4296162782 cites W2342749204 @default.
• W4296162782 cites W2358666620 @default.
• W4296162782 cites W2512803024 @default.
• W4296162782 cites W2588456342 @default.
• W4296162782 cites W2592323434 @default.
• W4296162782 cites W2610139434 @default.
• W4296162782 cites W2619291451 @default.
• W4296162782 cites W2751864106 @default.
• W4296162782 cites W2803712955 @default.
• W4296162782 cites W2808483153 @default.
• W4296162782 cites W2902154838 @default.
• W4296162782 cites W2908002252 @default.
• W4296162782 cites W2916749909 @default.
• W4296162782 cites W2920347097 @default.
• W4296162782 cites W2936160979 @default.
• W4296162782 cites W2950886245 @default.
• W4296162782 cites W2970474312 @default.
• W4296162782 cites W2989334492 @default.
• W4296162782 cites W3008287292 @default.
• W4296162782 cites W3010038216 @default.
• W4296162782 cites W3014540555 @default.
• W4296162782 cites W3015251081 @default.
• W4296162782 cites W3091549242 @default.
• W4296162782 cites W3107569316 @default.
• W4296162782 cites W3133792727 @default.
• W4296162782 cites W3216835863 @default.
• W4296162782 cites W4205856135 @default.
• W4296162782 doi "https://doi.org/10.1016/j.envres.2022.114181" @default.
• W4296162782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36113572" @default.
• W4296162782 hasPublicationYear "2022" @default.
• W4296162782 type Work @default.
• W4296162782 citedByCount "1" @default.
• W4296162782 countsByYear W42961627822022 @default.
• W4296162782 crossrefType "journal-article" @default.
• W4296162782 hasAuthorship W4296162782A5015928630 @default.
• W4296162782 hasAuthorship W4296162782A5020532478 @default.
• W4296162782 hasAuthorship W4296162782A5027240571 @default.
• W4296162782 hasAuthorship W4296162782A5037828672 @default.
• W4296162782 hasAuthorship W4296162782A5043474706 @default.
• W4296162782 hasAuthorship W4296162782A5045438428 @default.
• W4296162782 hasAuthorship W4296162782A5057311321 @default.
• W4296162782 hasAuthorship W4296162782A5064605523 @default.
• W4296162782 hasAuthorship W4296162782A5087506428 @default.
• W4296162782 hasConcept C104317684 @default.
• W4296162782 hasConcept C126322002 @default.
• W4296162782 hasConcept C134018914 @default.
• W4296162782 hasConcept C140173407 @default.
• W4296162782 hasConcept C148762608 @default.
• W4296162782 hasConcept C150194340 @default.
• W4296162782 hasConcept C169760540 @default.
• W4296162782 hasConcept C190727270 @default.
• W4296162782 hasConcept C203014093 @default.
• W4296162782 hasConcept C2776151105 @default.
• W4296162782 hasConcept C2776914184 @default.
• W4296162782 hasConcept C2779830541 @default.
• W4296162782 hasConcept C2781161787 @default.
• W4296162782 hasConcept C44752575 @default.
• W4296162782 hasConcept C54355233 @default.
• W4296162782 hasConcept C71924100 @default.
• W4296162782 hasConcept C86803240 @default.
• W4296162782 hasConcept C87753298 @default.
• W4296162782 hasConceptScore W4296162782C104317684 @default.
• W4296162782 hasConceptScore W4296162782C126322002 @default.
• W4296162782 hasConceptScore W4296162782C134018914 @default.
• W4296162782 hasConceptScore W4296162782C140173407 @default.
• W4296162782 hasConceptScore W4296162782C148762608 @default.

• next