Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296195278> ?p ?o ?g. }
- W4296195278 abstract "Emerging evidence indicates that resolution of inflammation is a critical and dynamic endogenous process for host tissues defending against external invasive pathogens or internal tissue injury. It has long been known that autoimmune diseases and chronic inflammatory disorders are characterized by dysregulated immune responses, leading to excessive and uncontrol tissue inflammation. The dysregulation of epigenetic alterations including DNA methylation, posttranslational modifications to histone proteins, and noncoding RNA expression has been implicated in a host of inflammatory disorders and the immune system. The inflammatory response is considered as a critical trigger of epigenetic alterations that in turn intercede inflammatory actions. Thus, understanding the molecular mechanism that dictates the outcome of targeting epigenetic regulators for inflammatory disease is required for inflammation resolution. In this article, we elucidate the critical role of the nuclear factor-κB signaling pathway, JAK/STAT signaling pathway, and the NLRP3 inflammasome in chronic inflammatory diseases. And we formulate the relationship between inflammation, coronavirus disease 2019, and human cancers. Additionally, we review the mechanism of epigenetic modifications involved in inflammation and innate immune cells. All that matters is that we propose and discuss the rejuvenation potential of interventions that target epigenetic regulators and regulatory mechanisms for chronic inflammation-associated diseases to improve therapeutic outcomes." @default.
- W4296195278 created "2022-09-18" @default.
- W4296195278 creator A5011877804 @default.
- W4296195278 creator A5012753104 @default.
- W4296195278 creator A5023690905 @default.
- W4296195278 creator A5025513632 @default.
- W4296195278 creator A5029852189 @default.
- W4296195278 creator A5040232155 @default.
- W4296195278 creator A5057391062 @default.
- W4296195278 creator A5081143070 @default.
- W4296195278 creator A5082841034 @default.
- W4296195278 date "2022-09-15" @default.
- W4296195278 modified "2023-10-14" @default.
- W4296195278 title "Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy" @default.
- W4296195278 cites W1171241794 @default.
- W4296195278 cites W1490231232 @default.
- W4296195278 cites W1540118907 @default.
- W4296195278 cites W1561041814 @default.
- W4296195278 cites W1681030413 @default.
- W4296195278 cites W1810595542 @default.
- W4296195278 cites W1815163311 @default.
- W4296195278 cites W1920303762 @default.
- W4296195278 cites W1933555931 @default.
- W4296195278 cites W1945638502 @default.
- W4296195278 cites W1952278424 @default.
- W4296195278 cites W1964499676 @default.
- W4296195278 cites W1971200109 @default.
- W4296195278 cites W1973847028 @default.
- W4296195278 cites W1977868902 @default.
- W4296195278 cites W1978811100 @default.
- W4296195278 cites W1981671220 @default.
- W4296195278 cites W1982704134 @default.
- W4296195278 cites W1983962406 @default.
- W4296195278 cites W1984325291 @default.
- W4296195278 cites W1986781117 @default.
- W4296195278 cites W1987735941 @default.
- W4296195278 cites W1989211393 @default.
- W4296195278 cites W1989435502 @default.
- W4296195278 cites W1991047945 @default.
- W4296195278 cites W1991667131 @default.
- W4296195278 cites W1991957462 @default.
- W4296195278 cites W1993976394 @default.
- W4296195278 cites W1994009027 @default.
- W4296195278 cites W1994120609 @default.
- W4296195278 cites W1996922800 @default.
- W4296195278 cites W2000177767 @default.
- W4296195278 cites W2001555590 @default.
- W4296195278 cites W2002308845 @default.
- W4296195278 cites W2002698073 @default.
- W4296195278 cites W2004608668 @default.
- W4296195278 cites W2004763680 @default.
- W4296195278 cites W2006247279 @default.
- W4296195278 cites W2008041603 @default.
- W4296195278 cites W2010480763 @default.
- W4296195278 cites W2014869583 @default.
- W4296195278 cites W2022199909 @default.
- W4296195278 cites W2023155523 @default.
- W4296195278 cites W2024716296 @default.
- W4296195278 cites W2025597952 @default.
- W4296195278 cites W2026442138 @default.
- W4296195278 cites W2029903254 @default.
- W4296195278 cites W2031084334 @default.
- W4296195278 cites W2033162367 @default.
- W4296195278 cites W2033489247 @default.
- W4296195278 cites W2033906346 @default.
- W4296195278 cites W2034658745 @default.
- W4296195278 cites W2035478417 @default.
- W4296195278 cites W2038274440 @default.
- W4296195278 cites W2038449573 @default.
- W4296195278 cites W2038699841 @default.
- W4296195278 cites W2039915847 @default.
- W4296195278 cites W2041308303 @default.
- W4296195278 cites W2042433863 @default.
- W4296195278 cites W2042851093 @default.
- W4296195278 cites W2043276364 @default.
- W4296195278 cites W2045131038 @default.
- W4296195278 cites W2046208635 @default.
- W4296195278 cites W2047999657 @default.
- W4296195278 cites W2048903425 @default.
- W4296195278 cites W2050449334 @default.
- W4296195278 cites W2050996284 @default.
- W4296195278 cites W2052521175 @default.
- W4296195278 cites W2055397908 @default.
- W4296195278 cites W2059382687 @default.
- W4296195278 cites W2060403106 @default.
- W4296195278 cites W2060870400 @default.
- W4296195278 cites W2067510388 @default.
- W4296195278 cites W2067938485 @default.
- W4296195278 cites W2068872768 @default.
- W4296195278 cites W2070463916 @default.
- W4296195278 cites W2071854923 @default.
- W4296195278 cites W2075860675 @default.
- W4296195278 cites W2076984671 @default.
- W4296195278 cites W2079003739 @default.
- W4296195278 cites W2090760765 @default.
- W4296195278 cites W2093911922 @default.
- W4296195278 cites W2095590314 @default.
- W4296195278 cites W2095626300 @default.
- W4296195278 cites W2096083625 @default.
- W4296195278 cites W2096152863 @default.