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- W4296205211 abstract "Methyl pyropheophorbide-a (MPPa) is a chlorophyll degradation product that possesses excellent photophysical and photochemical properties, yet poor water solubility limits its clinical application. In this paper, a novel MPPa derivative, 31,32,7,8-tetrahydroxy-4 H-MPPa (HMPPa) was synthesized by oxidative hydrolysis of MPPa with potassium osmate. The four hydrophilic hydroxyl groups endow HMPPa with better water solubility (lipid water partition coefficient logP = −0.16), which solve the problem of MPPa aggregation in water. HMPPa has a long-wavelength near-infrared absorption at 740 nm that can achieve a deeper penetration depth in biological tissues, which allows HMPPa to be applied in deep tumor therapy. Moreover, HMPPa possesses a higher singlet oxygen quantum yield (62.65 %) than that of MPPa (56 %). MTT assay verified that HMPPa had a strong ability to inhibit the growth of HepG-2 cells and 4T1 cells, and the PDT effect was superior to that of MPPa. Cell morphology experiments and flow cytometry analysis showed that HMPPa could induce apoptosis via a mitochondrial pathway. In vivo study of HMPPa showed a significant PDT antitumor effect on 4T1 tumor-bearing mice (Balb/C). The tumor cells followed by treatment of HMPPa could be clearly observed under fluorescence microscopy, implying a good fluorescence imaging function of HMPPa." @default.
- W4296205211 created "2022-09-18" @default.
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- W4296205211 date "2022-11-01" @default.
- W4296205211 modified "2023-09-26" @default.
- W4296205211 title "Photodynamic antitumor activity of tetrahydroxyl-methyl pyropheophorbide-a with improved water-solubility and depth of treatment" @default.
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- W4296205211 doi "https://doi.org/10.1016/j.procbio.2022.09.017" @default.
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