FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296209052> ?p ?o ?g. }

• W4296209052 abstract "ABSTRACT Background A significant proportion of patients with SARS-CoV-2 infection develops long COVID with fatigue as one of the most disabling symptoms. We performed clinical and immunologic profiling of fatigued and non-fatigued long COVID patients and age and gender matched healthy controls (HCs). Methods We included 37 long COVID patients with and 36 without severe fatigue and assessed inflammation-related monocyte gene expression, serum levels of inflammatory cytokines, and leukocyte and lymphocyte subsets 3-6 months after hospital discharge, and followed clinical symptoms up to one year. Results Long COVID with fatigue represented a severe variant with many symptoms (median 9 [IQR 5.0-10.0] symptoms) and signs of cognitive failure (41%) and depression (>24%). Symptoms persisted up to one year follow-up. Fatigued patients showed increased expression of inflammatory genes in monocytes, increased serum IL-6, TNF-α, galectin-9, and CXCL10, and increased CD8+ T-lymphocytes compared to HCs. Non-fatigued long COVID patients were arbitrarily divided in those with moderately severe disease (4 [2.5-5.0] symptoms, primarily impaired fitness, n=25) and those with mild disease (1 [1.0-2.0] symptom, n=11). Symptoms in non-fatigued long COVID patients persisted up to one year follow-up. Moderately severe patients showed reduced CD45RO - naïve CD4 + T-lymphocytes and CD25+FOXP3+ regulatory CD4 + T-lymphocytes and limited monocyte and serum (galectin-9) inflammation. Mild patients showed monocyte and serum (IL-6, galectin-9) inflammation and decreased CD4 + T-lymphocyte subsets (T-helper 1 cells). Conclusion Long COVID with fatigue is associated with many concurrent and persistent symptoms up to one year after hospitalization and with clear signs of low grade inflammation and increased CD8 + T-lymphocytes. We showed that long COVID is a clinical and immunologic heterogeneous disorder. Diagnostic tools and personalized therapies combatting the diverse immune abnormalities might be required to alleviate the persisting disabling complaints of the patients." @default.
• W4296209052 created "2022-09-18" @default.
• W4296209052 creator A5004418707 @default.
• W4296209052 creator A5008677339 @default.
• W4296209052 creator A5008701519 @default.
• W4296209052 creator A5012937808 @default.
• W4296209052 creator A5022767933 @default.
• W4296209052 creator A5027736492 @default.
• W4296209052 creator A5034613907 @default.
• W4296209052 creator A5034861241 @default.
• W4296209052 creator A5041793132 @default.
• W4296209052 creator A5047803194 @default.
• W4296209052 creator A5050197978 @default.
• W4296209052 creator A5060348497 @default.
• W4296209052 creator A5065911146 @default.
• W4296209052 creator A5088544294 @default.
• W4296209052 date "2022-09-15" @default.
• W4296209052 modified "2023-10-18" @default.
• W4296209052 title "Severe fatigue as symptom of long COVID is characterized by increased expression of inflammatory genes in monocytes, increased serum pro-inflammatory cytokines, and increased CD8+ T-lymphocytes: A putative dysregulation of the immune-brain axis, the coagulation process, and auto-inflammation to explain the diversity of long COVID symptoms" @default.
• W4296209052 cites W1628085997 @default.
• W4296209052 cites W1988226846 @default.
• W4296209052 cites W1994247305 @default.
• W4296209052 cites W1995061023 @default.
• W4296209052 cites W1997914859 @default.
• W4296209052 cites W2011944029 @default.
• W4296209052 cites W2013799046 @default.
• W4296209052 cites W2024627663 @default.
• W4296209052 cites W2028635659 @default.
• W4296209052 cites W2045073655 @default.
• W4296209052 cites W2057159787 @default.
• W4296209052 cites W2067495470 @default.
• W4296209052 cites W2104153396 @default.
• W4296209052 cites W2121629072 @default.
• W4296209052 cites W2134543031 @default.
• W4296209052 cites W2149368476 @default.
• W4296209052 cites W2157884365 @default.
• W4296209052 cites W2159838806 @default.
• W4296209052 cites W2166281097 @default.
• W4296209052 cites W2167415296 @default.
• W4296209052 cites W2194524147 @default.
• W4296209052 cites W2237272801 @default.
• W4296209052 cites W2283669950 @default.
• W4296209052 cites W2321182980 @default.
• W4296209052 cites W2354144837 @default.
• W4296209052 cites W2777753808 @default.
• W4296209052 cites W2896006844 @default.
• W4296209052 cites W2901041673 @default.
• W4296209052 cites W2913635089 @default.
• W4296209052 cites W2954957027 @default.
• W4296209052 cites W2982116893 @default.
• W4296209052 cites W2998747347 @default.
• W4296209052 cites W3005609732 @default.
• W4296209052 cites W3011187754 @default.
• W4296209052 cites W3014957730 @default.
• W4296209052 cites W3047424726 @default.
• W4296209052 cites W3080504291 @default.
• W4296209052 cites W3094687032 @default.
• W4296209052 cites W3125396713 @default.
• W4296209052 cites W3129062455 @default.
• W4296209052 cites W3129093809 @default.
• W4296209052 cites W3142178656 @default.
• W4296209052 cites W3163235228 @default.
• W4296209052 cites W3166820281 @default.
• W4296209052 cites W3171906465 @default.
• W4296209052 cites W3173320502 @default.
• W4296209052 cites W3182939740 @default.
• W4296209052 cites W3184339862 @default.
• W4296209052 cites W3187717678 @default.
• W4296209052 cites W3200834066 @default.
• W4296209052 cites W3204570230 @default.
• W4296209052 cites W3206070584 @default.
• W4296209052 cites W3217743982 @default.
• W4296209052 cites W330443216 @default.
• W4296209052 cites W4200191765 @default.
• W4296209052 cites W4205760778 @default.
• W4296209052 cites W4210274015 @default.
• W4296209052 cites W4213144842 @default.
• W4296209052 cites W4220831943 @default.
• W4296209052 cites W4221026046 @default.
• W4296209052 cites W4226514831 @default.
• W4296209052 cites W4280509840 @default.
• W4296209052 cites W4280573405 @default.
• W4296209052 cites W4281701737 @default.
• W4296209052 cites W4282930007 @default.
• W4296209052 cites W4283260453 @default.
• W4296209052 cites W4283711430 @default.
• W4296209052 cites W4291097580 @default.
• W4296209052 cites W4292806894 @default.
• W4296209052 doi "https://doi.org/10.1101/2022.09.15.22279970" @default.
• W4296209052 hasPublicationYear "2022" @default.
• W4296209052 type Work @default.
• W4296209052 citedByCount "2" @default.
• W4296209052 countsByYear W42962090522022 @default.
• W4296209052 crossrefType "posted-content" @default.
• W4296209052 hasAuthorship W4296209052A5004418707 @default.
• W4296209052 hasAuthorship W4296209052A5008677339 @default.
• W4296209052 hasAuthorship W4296209052A5008701519 @default.
• W4296209052 hasAuthorship W4296209052A5012937808 @default.
• W4296209052 hasAuthorship W4296209052A5022767933 @default.
• W4296209052 hasAuthorship W4296209052A5027736492 @default.

• next