Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296210003> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4296210003 endingPage "9" @default.
- W4296210003 startingPage "1" @default.
- W4296210003 abstract "Objective. To investigate the association of the plasma level of cytokines and blood routine indexes with clinical characteristics in patients with cancer. Methods. We analyzed plasma samples derived from 134 cancer patients. Interleukins (IL) 1β, 2, 4, 5, 6, 8, 10, 12p70, 17, IFN-γ, IFN-α, and TNF-α, and blood routine indexes were measured. The associations of the levels of cytokine and blood routine indexes with demographic and clinical characteristics of cancer patients were analyzed. Partial least-squares discriminant analysis was employed to identify cancer metastasis using these plasma cytokine metrics as input. We compared the predictive effectiveness of numeric machine learning algorithms using these indexes and showed a promising model implemented with random forest. Results. Plasma levels of IL-6 and IL-8 in cancer patients with metastases were higher than those without metastases ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mi>P</mi> <mo><</mo> <mn>0.05</mn> </math> ). Cancer patients without metastases had significantly higher levels of plasma IL-12p70 and percentage of lymphocytes as compared with those with metastases ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M2> <mi>P</mi> <mo><</mo> <mn>0.05</mn> </math> ). Our random forest model showed the highest prediction performance (upper quantile AUC, 0.885) among the six machine learning algorithms we evaluated. Conclusion. Our findings suggest that plasma levels of IL-6, IL-8, and IL-12p70 and the percentage of lymphocytes could predict the recurrence, metastasis, and progression of cancer. Our findings will provide guidance for tumor monitoring and treatment." @default.
- W4296210003 created "2022-09-18" @default.
- W4296210003 creator A5001189701 @default.
- W4296210003 creator A5003286200 @default.
- W4296210003 creator A5023630102 @default.
- W4296210003 creator A5033886492 @default.
- W4296210003 creator A5034569398 @default.
- W4296210003 creator A5061826635 @default.
- W4296210003 creator A5064796885 @default.
- W4296210003 creator A5068563253 @default.
- W4296210003 creator A5086752846 @default.
- W4296210003 date "2022-09-16" @default.
- W4296210003 modified "2023-10-14" @default.
- W4296210003 title "Value of Cytokine Expression in Early Diagnosis and Prognosis of Tumor Metastasis" @default.
- W4296210003 cites W1969103696 @default.
- W4296210003 cites W1972853281 @default.
- W4296210003 cites W2000378305 @default.
- W4296210003 cites W2034329227 @default.
- W4296210003 cites W2044748328 @default.
- W4296210003 cites W2050516456 @default.
- W4296210003 cites W2064315259 @default.
- W4296210003 cites W2088741578 @default.
- W4296210003 cites W2091894720 @default.
- W4296210003 cites W2097147259 @default.
- W4296210003 cites W2099638559 @default.
- W4296210003 cites W2101899879 @default.
- W4296210003 cites W2107989579 @default.
- W4296210003 cites W2117692326 @default.
- W4296210003 cites W2121897702 @default.
- W4296210003 cites W2123105952 @default.
- W4296210003 cites W2162588927 @default.
- W4296210003 cites W2164664027 @default.
- W4296210003 cites W2220756562 @default.
- W4296210003 cites W2353835 @default.
- W4296210003 cites W2512931560 @default.
- W4296210003 cites W2626842659 @default.
- W4296210003 cites W2803009863 @default.
- W4296210003 cites W2988046914 @default.
- W4296210003 cites W3013038172 @default.
- W4296210003 cites W3165585845 @default.
- W4296210003 cites W4362218836 @default.
- W4296210003 doi "https://doi.org/10.1155/2022/8112190" @default.
- W4296210003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36157224" @default.
- W4296210003 hasPublicationYear "2022" @default.
- W4296210003 type Work @default.
- W4296210003 citedByCount "1" @default.
- W4296210003 countsByYear W42962100032023 @default.
- W4296210003 crossrefType "journal-article" @default.
- W4296210003 hasAuthorship W4296210003A5001189701 @default.
- W4296210003 hasAuthorship W4296210003A5003286200 @default.
- W4296210003 hasAuthorship W4296210003A5023630102 @default.
- W4296210003 hasAuthorship W4296210003A5033886492 @default.
- W4296210003 hasAuthorship W4296210003A5034569398 @default.
- W4296210003 hasAuthorship W4296210003A5061826635 @default.
- W4296210003 hasAuthorship W4296210003A5064796885 @default.
- W4296210003 hasAuthorship W4296210003A5068563253 @default.
- W4296210003 hasAuthorship W4296210003A5086752846 @default.
- W4296210003 hasBestOaLocation W42962100031 @default.
- W4296210003 hasConcept C11413529 @default.
- W4296210003 hasConcept C121608353 @default.
- W4296210003 hasConcept C126322002 @default.
- W4296210003 hasConcept C143998085 @default.
- W4296210003 hasConcept C2778690821 @default.
- W4296210003 hasConcept C2779013556 @default.
- W4296210003 hasConcept C33923547 @default.
- W4296210003 hasConcept C71924100 @default.
- W4296210003 hasConcept C90924648 @default.
- W4296210003 hasConceptScore W4296210003C11413529 @default.
- W4296210003 hasConceptScore W4296210003C121608353 @default.
- W4296210003 hasConceptScore W4296210003C126322002 @default.
- W4296210003 hasConceptScore W4296210003C143998085 @default.
- W4296210003 hasConceptScore W4296210003C2778690821 @default.
- W4296210003 hasConceptScore W4296210003C2779013556 @default.
- W4296210003 hasConceptScore W4296210003C33923547 @default.
- W4296210003 hasConceptScore W4296210003C71924100 @default.
- W4296210003 hasConceptScore W4296210003C90924648 @default.
- W4296210003 hasFunder F4320321921 @default.
- W4296210003 hasLocation W42962100031 @default.
- W4296210003 hasLocation W42962100032 @default.
- W4296210003 hasLocation W42962100033 @default.
- W4296210003 hasOpenAccess W4296210003 @default.
- W4296210003 hasPrimaryLocation W42962100031 @default.
- W4296210003 hasRelatedWork W2023543014 @default.
- W4296210003 hasRelatedWork W2055887390 @default.
- W4296210003 hasRelatedWork W2061219771 @default.
- W4296210003 hasRelatedWork W2121537719 @default.
- W4296210003 hasRelatedWork W2127396827 @default.
- W4296210003 hasRelatedWork W2128222437 @default.
- W4296210003 hasRelatedWork W2174830166 @default.
- W4296210003 hasRelatedWork W2314032833 @default.
- W4296210003 hasRelatedWork W2568845480 @default.
- W4296210003 hasRelatedWork W2580006192 @default.
- W4296210003 hasVolume "2022" @default.
- W4296210003 isParatext "false" @default.
- W4296210003 isRetracted "false" @default.
- W4296210003 workType "article" @default.