Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296219962> ?p ?o ?g. }
- W4296219962 endingPage "705" @default.
- W4296219962 startingPage "689" @default.
- W4296219962 abstract "Abstract Hypoxia‐inducible factor 2 α (HIF2α), a transcription factor playing a vital role in hypoxia, promotes cancer metastasis. We had previously reported that the cancer‐related gene integration site 6 / eukaryotic translation initiation factor 3 subunit e ( INT6/eIF3e ) negatively regulates the protein stability of HIF2α in an oxygen‐independent manner. Presently, the downstream targets for INT6/eIF3e ‐regulated HIF2α are unknown. Given the roles of HIF2α and INT6/eIF3e in epithelial–mesenchymal transition (EMT) that promotes cancer metastasis, we hypothesized that INT6/eIF3e ‐regulated HIF2α controls EMT. This study shows that INT6/eIF3e knockdown in lung carcinoma A549 cells led to increased expression of HIF2α protein and an EMT‐like phenotypic change. The increased HIF2α subsequently repressed the E‐cadherin gene. Mechanistically, HIF2α interacts with the twist family bHLH transcription factor 1 (TWIST1) known to regulate EMT process, and binds to the proximal promoter region of E‐cadherin, repressing it. Collectively, our work demonstrates that HIF2α, regulated by INT6/eIF3e , represses the E‐cadherin gene through TWIST1 to enhance EMT, suggesting a role of the INT6/eIF3e ‐HIF2α axis in cancer metastasis." @default.
- W4296219962 created "2022-09-18" @default.
- W4296219962 creator A5025419095 @default.
- W4296219962 creator A5089304014 @default.
- W4296219962 creator A5091911851 @default.
- W4296219962 date "2022-09-29" @default.
- W4296219962 modified "2023-10-16" @default.
- W4296219962 title "<scp>INT6</scp>/<scp>eIF3e</scp> represses E‐cadherin expression through <scp>HIF2α</scp> in lung carcinoma <scp>A549</scp> cells" @default.
- W4296219962 cites W1749022239 @default.
- W4296219962 cites W1964081206 @default.
- W4296219962 cites W1964847767 @default.
- W4296219962 cites W1969734439 @default.
- W4296219962 cites W1970792104 @default.
- W4296219962 cites W1971886895 @default.
- W4296219962 cites W1972784739 @default.
- W4296219962 cites W1973541913 @default.
- W4296219962 cites W1975545468 @default.
- W4296219962 cites W1984395134 @default.
- W4296219962 cites W1987824473 @default.
- W4296219962 cites W1990218742 @default.
- W4296219962 cites W1998664010 @default.
- W4296219962 cites W2000624133 @default.
- W4296219962 cites W2001890728 @default.
- W4296219962 cites W2003427751 @default.
- W4296219962 cites W2005868568 @default.
- W4296219962 cites W2010386340 @default.
- W4296219962 cites W2023338540 @default.
- W4296219962 cites W2024593529 @default.
- W4296219962 cites W2028022492 @default.
- W4296219962 cites W2033866613 @default.
- W4296219962 cites W2035340827 @default.
- W4296219962 cites W2036008499 @default.
- W4296219962 cites W2036050422 @default.
- W4296219962 cites W2040031153 @default.
- W4296219962 cites W2042216712 @default.
- W4296219962 cites W2046440184 @default.
- W4296219962 cites W2068945039 @default.
- W4296219962 cites W2070407539 @default.
- W4296219962 cites W2076583198 @default.
- W4296219962 cites W2081552372 @default.
- W4296219962 cites W2085609942 @default.
- W4296219962 cites W2086721790 @default.
- W4296219962 cites W2087377825 @default.
- W4296219962 cites W2090627731 @default.
- W4296219962 cites W2091589316 @default.
- W4296219962 cites W2094242056 @default.
- W4296219962 cites W2109998353 @default.
- W4296219962 cites W2114920820 @default.
- W4296219962 cites W2129172191 @default.
- W4296219962 cites W2134361367 @default.
- W4296219962 cites W2135705997 @default.
- W4296219962 cites W2136875815 @default.
- W4296219962 cites W2147718842 @default.
- W4296219962 cites W2151870298 @default.
- W4296219962 cites W2155415917 @default.
- W4296219962 cites W2161728771 @default.
- W4296219962 cites W2167171916 @default.
- W4296219962 cites W2171819173 @default.
- W4296219962 cites W2205589943 @default.
- W4296219962 cites W2258102129 @default.
- W4296219962 cites W2300955327 @default.
- W4296219962 cites W2319824591 @default.
- W4296219962 cites W2597029977 @default.
- W4296219962 cites W2603102282 @default.
- W4296219962 cites W2794479004 @default.
- W4296219962 cites W2943005115 @default.
- W4296219962 cites W3045386060 @default.
- W4296219962 cites W3083393835 @default.
- W4296219962 cites W4237970323 @default.
- W4296219962 doi "https://doi.org/10.1111/gtc.12984" @default.
- W4296219962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36116043" @default.
- W4296219962 hasPublicationYear "2022" @default.
- W4296219962 type Work @default.
- W4296219962 citedByCount "1" @default.
- W4296219962 countsByYear W42962199622023 @default.
- W4296219962 crossrefType "journal-article" @default.
- W4296219962 hasAuthorship W4296219962A5025419095 @default.
- W4296219962 hasAuthorship W4296219962A5089304014 @default.
- W4296219962 hasAuthorship W4296219962A5091911851 @default.
- W4296219962 hasConcept C104317684 @default.
- W4296219962 hasConcept C173396325 @default.
- W4296219962 hasConcept C502942594 @default.
- W4296219962 hasConcept C54355233 @default.
- W4296219962 hasConcept C86339819 @default.
- W4296219962 hasConcept C86803240 @default.
- W4296219962 hasConceptScore W4296219962C104317684 @default.
- W4296219962 hasConceptScore W4296219962C173396325 @default.
- W4296219962 hasConceptScore W4296219962C502942594 @default.
- W4296219962 hasConceptScore W4296219962C54355233 @default.
- W4296219962 hasConceptScore W4296219962C86339819 @default.
- W4296219962 hasConceptScore W4296219962C86803240 @default.
- W4296219962 hasFunder F4320334764 @default.
- W4296219962 hasIssue "12" @default.
- W4296219962 hasLocation W42962199621 @default.
- W4296219962 hasLocation W42962199622 @default.
- W4296219962 hasOpenAccess W4296219962 @default.
- W4296219962 hasPrimaryLocation W42962199621 @default.
- W4296219962 hasRelatedWork W1564105650 @default.