FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4296226236> ?p ?o ?g. }

• W4296226236 endingPage "104" @default.
• W4296226236 startingPage "104" @default.
• W4296226236 abstract "Type 2 diabetes mellitus (T2DM) is known to induce inflammation and activation of neutrophils causing the release of neutrophil elastase (NE), a pro-inflammatory proteinase. The activity of NE is regulated by endogenous inhibitors alpha1-antitrypsin (α1-AT) and alpha2-macroglobulin (α2-MG). Disrupted proteolytic homeostasis in T2DM patients is one of the causes for vascular complications. This study was carried out for evaluating the levels of plasma NE, α1-AT, α2-MG and NE-α1-AT complex to understand their roles in the pathophysiology of diabetic nephropathy (DN) and diabetic retinopathy (DR).A total of 240 participants (Control, n=60; T2DM, n=60; DN, n=60; and DR, n=60) were recruited after recording history, clinical examination and laboratory investigations. Retinopathy was confirmed by fundoscopy and nephropathy by urinary albumin excretion and serum creatinine levels. NE was measured using STANA. α1-AT, α2-MG and NE-α1-AT complex were estimated by ELISA.Baseline clinical and laboratory findings were confirmatory to the study groups. The mean elastase activity was higher (P<0.0005) in diabetes groups (T2DM=0.73±0.31, DN=0.87±0.35, DR=0.76±0.41) than controls (0.35±0.20). The levels of α1-AT were lower in DR (8.77±2.85) than DN (26.26±6.16) and T2DM (41.13±14.06) when juxtaposed with controls (122.95±25.71). The approximate fold decrease of α1-AT levels was 15 for DR and four for DN compared to controls. The levels of α2-MG were lowered in T2DM (167.29±30.45), DN (144.66±13.72), and DR (104.67±11.47) than controls (208.87±31.16). The NE-α1-AT complex levels were: controls (215.83±13.61), T2DM (98.85±23.85), DN (129.26±20.40) and DR (153.25±17.11).Homeostasis of NE, α1-AT and α2-MG is disrupted in T2DM, DN and DR. Strikingly reduced levels of α1-AT observed in DR are indicative of its possible role in the pathophysiology of retinopathy and emphasizes α1-AT as a plausible therapeutic target." @default.
• W4296226236 created "2022-09-18" @default.
• W4296226236 creator A5006724883 @default.
• W4296226236 creator A5011323598 @default.
• W4296226236 creator A5046722821 @default.
• W4296226236 date "2022-01-01" @default.
• W4296226236 modified "2023-09-23" @default.
• W4296226236 title "Selective decrease in alpha1-antitrypsin levels in diabetic retinopathy: Could the levels of it be playing a role in the pathophysiology of diabetic retinopathy?" @default.
• W4296226236 cites W1540679824 @default.
• W4296226236 cites W1562598284 @default.
• W4296226236 cites W1589733194 @default.
• W4296226236 cites W1987415392 @default.
• W4296226236 cites W1997552453 @default.
• W4296226236 cites W2006170518 @default.
• W4296226236 cites W2032227357 @default.
• W4296226236 cites W2049285262 @default.
• W4296226236 cites W2059814720 @default.
• W4296226236 cites W2064146867 @default.
• W4296226236 cites W2071011478 @default.
• W4296226236 cites W2072322888 @default.
• W4296226236 cites W2081754970 @default.
• W4296226236 cites W2083341036 @default.
• W4296226236 cites W2086118617 @default.
• W4296226236 cites W2101717411 @default.
• W4296226236 cites W2115971041 @default.
• W4296226236 cites W2120186044 @default.
• W4296226236 cites W2127511591 @default.
• W4296226236 cites W2128290503 @default.
• W4296226236 cites W2132080783 @default.
• W4296226236 cites W2137522692 @default.
• W4296226236 cites W2273736767 @default.
• W4296226236 cites W2303236807 @default.
• W4296226236 cites W2500162161 @default.
• W4296226236 cites W2793401320 @default.
• W4296226236 cites W2804641118 @default.
• W4296226236 cites W2883732557 @default.
• W4296226236 cites W2889526011 @default.
• W4296226236 cites W2944544314 @default.
• W4296226236 cites W3004963833 @default.
• W4296226236 cites W4299436089 @default.
• W4296226236 doi "https://doi.org/10.4103/ijmr.ijmr_1293_19" @default.
• W4296226236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36124492" @default.
• W4296226236 hasPublicationYear "2022" @default.
• W4296226236 type Work @default.
• W4296226236 citedByCount "0" @default.
• W4296226236 crossrefType "journal-article" @default.
• W4296226236 hasAuthorship W4296226236A5006724883 @default.
• W4296226236 hasAuthorship W4296226236A5011323598 @default.
• W4296226236 hasAuthorship W4296226236A5046722821 @default.
• W4296226236 hasBestOaLocation W42962262362 @default.
• W4296226236 hasConcept C10162356 @default.
• W4296226236 hasConcept C126322002 @default.
• W4296226236 hasConcept C134018914 @default.
• W4296226236 hasConcept C181199279 @default.
• W4296226236 hasConcept C185592680 @default.
• W4296226236 hasConcept C2776125364 @default.
• W4296226236 hasConcept C2776914184 @default.
• W4296226236 hasConcept C2778313320 @default.
• W4296226236 hasConcept C2779829184 @default.
• W4296226236 hasConcept C2779922275 @default.
• W4296226236 hasConcept C2780306776 @default.
• W4296226236 hasConcept C2781044401 @default.
• W4296226236 hasConcept C2781184683 @default.
• W4296226236 hasConcept C2910068830 @default.
• W4296226236 hasConcept C55493867 @default.
• W4296226236 hasConcept C555293320 @default.
• W4296226236 hasConcept C71924100 @default.
• W4296226236 hasConceptScore W4296226236C10162356 @default.
• W4296226236 hasConceptScore W4296226236C126322002 @default.
• W4296226236 hasConceptScore W4296226236C134018914 @default.
• W4296226236 hasConceptScore W4296226236C181199279 @default.
• W4296226236 hasConceptScore W4296226236C185592680 @default.
• W4296226236 hasConceptScore W4296226236C2776125364 @default.
• W4296226236 hasConceptScore W4296226236C2776914184 @default.
• W4296226236 hasConceptScore W4296226236C2778313320 @default.
• W4296226236 hasConceptScore W4296226236C2779829184 @default.
• W4296226236 hasConceptScore W4296226236C2779922275 @default.
• W4296226236 hasConceptScore W4296226236C2780306776 @default.
• W4296226236 hasConceptScore W4296226236C2781044401 @default.
• W4296226236 hasConceptScore W4296226236C2781184683 @default.
• W4296226236 hasConceptScore W4296226236C2910068830 @default.
• W4296226236 hasConceptScore W4296226236C55493867 @default.
• W4296226236 hasConceptScore W4296226236C555293320 @default.
• W4296226236 hasConceptScore W4296226236C71924100 @default.
• W4296226236 hasIssue "1" @default.
• W4296226236 hasLocation W42962262361 @default.
• W4296226236 hasLocation W42962262362 @default.
• W4296226236 hasLocation W42962262363 @default.
• W4296226236 hasOpenAccess W4296226236 @default.
• W4296226236 hasPrimaryLocation W42962262361 @default.
• W4296226236 hasRelatedWork W2095529597 @default.
• W4296226236 hasRelatedWork W2162972075 @default.
• W4296226236 hasRelatedWork W2324661065 @default.
• W4296226236 hasRelatedWork W2329268222 @default.
• W4296226236 hasRelatedWork W2408875421 @default.
• W4296226236 hasRelatedWork W3202342315 @default.
• W4296226236 hasRelatedWork W4200129320 @default.
• W4296226236 hasRelatedWork W4229050006 @default.

• next